Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016242494> ?p ?o ?g. }
- W3016242494 endingPage "2679" @default.
- W3016242494 startingPage "2676" @default.
- W3016242494 abstract "Abstract The green and sustainable synthesis of chemicals from renewable feedstocks by a biotransformation approach has gained increasing attention in recent years. In this work, we developed enzymatic cascades to efficiently convert l ‐phenylalanine into 2‐phenylethanol (2‐PE) and phenylacetic acid (PAA), l ‐tyrosine into tyrosol ( p ‐hydroxyphenylethanol, p ‐HPE) and p ‐hydroxyphenylacetic acid ( p ‐HPAA). The enzymatic cascade was cast into an aromatic aldehyde formation module, followed by an aldehyde reduction module, or aldehyde oxidation module, to achieve one‐pot biotransformation by using recombinant Escherichia coli . Biotransformation of 50 mM l ‐Phe produced 6.76 g/L PAA with more than 99 % conversion and 5.95 g/L of 2‐PE with 97 % conversion. The bioconversion efficiencies of p ‐HPAA and p ‐HPE from l ‐Tyr reached to 88 and 94 %, respectively. In addition, m ‐fluoro‐phenylalanine was further employed as an unnatural aromatic amino acid substrate to obtain m ‐fluoro‐phenylacetic acid; >96 % conversion was achieved. Our results thus demonstrated high‐yielding and potential industrial synthesis of above aromatic compounds by one‐pot cascade biocatalysis." @default.
- W3016242494 created "2020-04-17" @default.
- W3016242494 creator A5020579375 @default.
- W3016242494 creator A5022802322 @default.
- W3016242494 creator A5032189070 @default.
- W3016242494 creator A5041830840 @default.
- W3016242494 date "2020-05-27" @default.
- W3016242494 modified "2023-10-17" @default.
- W3016242494 title "Efficient Synthesis of Phenylacetate and 2‐Phenylethanol by Modular Cascade Biocatalysis" @default.
- W3016242494 cites W1876458776 @default.
- W3016242494 cites W1912565110 @default.
- W3016242494 cites W1962099868 @default.
- W3016242494 cites W1972085708 @default.
- W3016242494 cites W1976236461 @default.
- W3016242494 cites W1977822177 @default.
- W3016242494 cites W1981143570 @default.
- W3016242494 cites W1984180361 @default.
- W3016242494 cites W1990931150 @default.
- W3016242494 cites W2000810737 @default.
- W3016242494 cites W2002752790 @default.
- W3016242494 cites W2013381210 @default.
- W3016242494 cites W2025902887 @default.
- W3016242494 cites W2034351729 @default.
- W3016242494 cites W2038554141 @default.
- W3016242494 cites W2053439928 @default.
- W3016242494 cites W2054799159 @default.
- W3016242494 cites W2089041533 @default.
- W3016242494 cites W2096684484 @default.
- W3016242494 cites W2104327886 @default.
- W3016242494 cites W2109515222 @default.
- W3016242494 cites W2128417005 @default.
- W3016242494 cites W2144508237 @default.
- W3016242494 cites W2163052164 @default.
- W3016242494 cites W2166230209 @default.
- W3016242494 cites W2168555479 @default.
- W3016242494 cites W2187650526 @default.
- W3016242494 cites W2509818773 @default.
- W3016242494 cites W2586799248 @default.
- W3016242494 cites W2617259912 @default.
- W3016242494 cites W2619629451 @default.
- W3016242494 cites W2735793452 @default.
- W3016242494 cites W2759850104 @default.
- W3016242494 cites W2781909511 @default.
- W3016242494 cites W2790493352 @default.
- W3016242494 cites W2807094435 @default.
- W3016242494 cites W2810361637 @default.
- W3016242494 cites W2902463584 @default.
- W3016242494 cites W2954675904 @default.
- W3016242494 cites W3004626170 @default.
- W3016242494 cites W4230685241 @default.
- W3016242494 cites W4255818941 @default.
- W3016242494 doi "https://doi.org/10.1002/cbic.202000182" @default.
- W3016242494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32291886" @default.
- W3016242494 hasPublicationYear "2020" @default.
- W3016242494 type Work @default.
- W3016242494 sameAs 3016242494 @default.
- W3016242494 citedByCount "8" @default.
- W3016242494 countsByYear W30162424942020 @default.
- W3016242494 countsByYear W30162424942021 @default.
- W3016242494 countsByYear W30162424942022 @default.
- W3016242494 crossrefType "journal-article" @default.
- W3016242494 hasAuthorship W3016242494A5020579375 @default.
- W3016242494 hasAuthorship W3016242494A5022802322 @default.
- W3016242494 hasAuthorship W3016242494A5032189070 @default.
- W3016242494 hasAuthorship W3016242494A5041830840 @default.
- W3016242494 hasConcept C100544194 @default.
- W3016242494 hasConcept C161790260 @default.
- W3016242494 hasConcept C178790620 @default.
- W3016242494 hasConcept C181199279 @default.
- W3016242494 hasConcept C185592680 @default.
- W3016242494 hasConcept C191503008 @default.
- W3016242494 hasConcept C2777431362 @default.
- W3016242494 hasConcept C2778990612 @default.
- W3016242494 hasConcept C2779825165 @default.
- W3016242494 hasConcept C2780074830 @default.
- W3016242494 hasConcept C27881333 @default.
- W3016242494 hasConcept C515207424 @default.
- W3016242494 hasConcept C55493867 @default.
- W3016242494 hasConcept C58548122 @default.
- W3016242494 hasConcept C65024703 @default.
- W3016242494 hasConceptScore W3016242494C100544194 @default.
- W3016242494 hasConceptScore W3016242494C161790260 @default.
- W3016242494 hasConceptScore W3016242494C178790620 @default.
- W3016242494 hasConceptScore W3016242494C181199279 @default.
- W3016242494 hasConceptScore W3016242494C185592680 @default.
- W3016242494 hasConceptScore W3016242494C191503008 @default.
- W3016242494 hasConceptScore W3016242494C2777431362 @default.
- W3016242494 hasConceptScore W3016242494C2778990612 @default.
- W3016242494 hasConceptScore W3016242494C2779825165 @default.
- W3016242494 hasConceptScore W3016242494C2780074830 @default.
- W3016242494 hasConceptScore W3016242494C27881333 @default.
- W3016242494 hasConceptScore W3016242494C515207424 @default.
- W3016242494 hasConceptScore W3016242494C55493867 @default.
- W3016242494 hasConceptScore W3016242494C58548122 @default.
- W3016242494 hasConceptScore W3016242494C65024703 @default.
- W3016242494 hasFunder F4320325434 @default.
- W3016242494 hasIssue "18" @default.
- W3016242494 hasLocation W30162424941 @default.