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- W3016284863 abstract "Cancer stemness represents one of the major mechanisms that predispose patients to tumor aggressiveness, metastasis, and treatment resistance. MicroRNA biogenesis is an important process controlling miRNA processing and maturation. Deregulation of miRNA biogenesis can lead to tumorigenesis and cancer stemness. DDX17 is a co-factor of the miRNA microprocessor. Misregulation of DDX17 can be associated with cancer stemness. K63-linked polyubiquitination of DDX17 presents a concerted mechanism of decreased synthesis of stemness-inhibiting miRNAs and increased transcriptional activation of stemness-related gene expression. K63-linked polyubiquitination of HAUSP serves as a scaffold to anchor HIF-1α, CBP, the mediator complex, and the super-elongation complex to enhance HIF-1α-induced gene transcription. Recent progress in RNA modifications shows that RNA N6-methyladenosine (m6A) modification is a crucial mechanism to regulate RNA levels. M6A modification of miRNAs can also be linked to tumorigenesis and cancer stemness. Overall, miRNA biogenesis and K63-linked polyubiquitination of DDX17 play an important role in the induction of cancer stemness. Delineation of the mechanisms and identification of suitable targets may provide new therapeutic options for treatment-resistant cancers." @default.
- W3016284863 created "2020-04-24" @default.
- W3016284863 creator A5061073629 @default.
- W3016284863 date "2020-04-01" @default.
- W3016284863 modified "2023-10-17" @default.
- W3016284863 title "The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness" @default.
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- W3016284863 doi "https://doi.org/10.1016/j.bj.2020.03.001" @default.
- W3016284863 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7283569" @default.
- W3016284863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32513392" @default.
- W3016284863 hasPublicationYear "2020" @default.
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