FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016294135> ?p ?o ?g. }

• W3016294135 abstract "The PACIFIC trial of durvalumab administered for 1 year to patients with stage III lung cancers has set a new standard of care. PACIFIC established the role of immune checkpoint inhibitors (ICIs) for individuals with inoperable and unresectable locally advanced lung cancers that achieve disease control from concurrent chemoradiation. For patients with resectable and operable disease, ICIs administered before surgery, either alone (JHU/MSK, LCMC3, and NEOSTAR) or in combination with chemotherapy (Columbia/MGH and NADIM), have yielded high rates of major pathologic response in resection specimens, an outcome measure that correlates with improved progression-free survival and overall survival. These results have brought forth the dilemma of how to choose the optimal local therapy—either definitive concurrent chemoradiation or surgery—to use with an ICI for patients with stage III lung cancers that are both operable and resectable. Here, we review the data that support the use of each local therapy. Recent successes have also raised the possibility that using ICIs in patients with earlier stages of lung cancer will enhance curability. Randomized trials are underway; however, until they read out, physicians must choose between local and systemic therapies on the basis of the information we have today. Research demonstrates that using surgery, radiation, chemotherapy, and ICIs improve all efficacy outcomes and curability. All modalities should be considered in every patient with locally advanced lung cancer. It is imperative that a multimodality discussion that includes the possible addition of ICIs takes place to choose the best modality and sequence of therapies for each patient." @default.
• W3016294135 created "2020-04-24" @default.
• W3016294135 creator A5007868555 @default.
• W3016294135 creator A5033217800 @default.
• W3016294135 creator A5039791495 @default.
• W3016294135 creator A5041134366 @default.
• W3016294135 creator A5057281549 @default.
• W3016294135 creator A5076621000 @default.
• W3016294135 creator A5090385143 @default.
• W3016294135 date "2020-05-01" @default.
• W3016294135 modified "2023-10-14" @default.
• W3016294135 title "Making Checkpoint Inhibitors Part of Treatment of Patients With Locally Advanced Lung Cancers: The Time Is Now" @default.
• W3016294135 cites W1912124796 @default.
• W3016294135 cites W1968899146 @default.
• W3016294135 cites W1988160404 @default.
• W3016294135 cites W1994826332 @default.
• W3016294135 cites W2032166347 @default.
• W3016294135 cites W2038716687 @default.
• W3016294135 cites W2060070314 @default.
• W3016294135 cites W2104701073 @default.
• W3016294135 cites W2127733313 @default.
• W3016294135 cites W2134291074 @default.
• W3016294135 cites W2155033435 @default.
• W3016294135 cites W2159094759 @default.
• W3016294135 cites W2264000214 @default.
• W3016294135 cites W2291298003 @default.
• W3016294135 cites W2521503673 @default.
• W3016294135 cites W2527905628 @default.
• W3016294135 cites W2586030734 @default.
• W3016294135 cites W2607970143 @default.
• W3016294135 cites W2610224116 @default.
• W3016294135 cites W2750254726 @default.
• W3016294135 cites W2753065806 @default.
• W3016294135 cites W2754606968 @default.
• W3016294135 cites W2792342073 @default.
• W3016294135 cites W2796582438 @default.
• W3016294135 cites W2798160602 @default.
• W3016294135 cites W2892483359 @default.
• W3016294135 cites W2893824814 @default.
• W3016294135 cites W2897191292 @default.
• W3016294135 cites W2897612290 @default.
• W3016294135 cites W2902218997 @default.
• W3016294135 cites W2909427482 @default.
• W3016294135 cites W2943437728 @default.
• W3016294135 cites W2947111267 @default.
• W3016294135 cites W2947436142 @default.
• W3016294135 cites W2947779096 @default.
• W3016294135 cites W2971865214 @default.
• W3016294135 cites W2976744492 @default.
• W3016294135 cites W2980537150 @default.
• W3016294135 cites W2990621342 @default.
• W3016294135 cites W2992931937 @default.
• W3016294135 cites W3000712054 @default.
• W3016294135 cites W3003310139 @default.
• W3016294135 cites W4210394199 @default.
• W3016294135 doi "https://doi.org/10.1200/edbk_280807" @default.
• W3016294135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7357690" @default.
• W3016294135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32298162" @default.
• W3016294135 hasPublicationYear "2020" @default.
• W3016294135 type Work @default.
• W3016294135 sameAs 3016294135 @default.
• W3016294135 citedByCount "5" @default.
• W3016294135 countsByYear W30162941352020 @default.
• W3016294135 countsByYear W30162941352021 @default.
• W3016294135 countsByYear W30162941352022 @default.
• W3016294135 crossrefType "journal-article" @default.
• W3016294135 hasAuthorship W3016294135A5007868555 @default.
• W3016294135 hasAuthorship W3016294135A5033217800 @default.
• W3016294135 hasAuthorship W3016294135A5039791495 @default.
• W3016294135 hasAuthorship W3016294135A5041134366 @default.
• W3016294135 hasAuthorship W3016294135A5057281549 @default.
• W3016294135 hasAuthorship W3016294135A5076621000 @default.
• W3016294135 hasAuthorship W3016294135A5090385143 @default.
• W3016294135 hasBestOaLocation W30162941351 @default.
• W3016294135 hasConcept C121608353 @default.
• W3016294135 hasConcept C126322002 @default.
• W3016294135 hasConcept C141071460 @default.
• W3016294135 hasConcept C143998085 @default.
• W3016294135 hasConcept C146357865 @default.
• W3016294135 hasConcept C151730666 @default.
• W3016294135 hasConcept C168563851 @default.
• W3016294135 hasConcept C177713679 @default.
• W3016294135 hasConcept C2776256026 @default.
• W3016294135 hasConcept C2776694085 @default.
• W3016294135 hasConcept C2777701055 @default.
• W3016294135 hasConcept C2777742743 @default.
• W3016294135 hasConcept C2779134260 @default.
• W3016294135 hasConcept C2780057760 @default.
• W3016294135 hasConcept C509974204 @default.
• W3016294135 hasConcept C71924100 @default.
• W3016294135 hasConcept C86803240 @default.
• W3016294135 hasConceptScore W3016294135C121608353 @default.
• W3016294135 hasConceptScore W3016294135C126322002 @default.
• W3016294135 hasConceptScore W3016294135C141071460 @default.
• W3016294135 hasConceptScore W3016294135C143998085 @default.
• W3016294135 hasConceptScore W3016294135C146357865 @default.
• W3016294135 hasConceptScore W3016294135C151730666 @default.
• W3016294135 hasConceptScore W3016294135C168563851 @default.
• W3016294135 hasConceptScore W3016294135C177713679 @default.
• W3016294135 hasConceptScore W3016294135C2776256026 @default.

• next