FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016306699> ?p ?o ?g. }

• W3016306699 abstract "Abstract Herein, we described a scale‐up strategy focused on the dissolved carbon dioxide concentration (dCO 2 ) during fed‐batch cultivation of Chinese hamster ovary cells. A fed‐batch culture process for a 2000‐L scale stainless steel (SS) bioreactor was scaled‐up from similarly shaped 200‐L scale bioreactors based on power input per unit volume ( P / V ). However, during the 2000‐L fed‐batch culture, the dCO 2 was higher compared with the 200‐L scale bioreactor. Therefore, we developed an alternative approach by evaluating the k L a values of O 2 ( k L a[O 2 ]) and CO 2 [ k L a(CO 2 )] in the SS bioreactors as a scale‐up factor for dCO 2 reduction. The k L a ratios [ k L a(CO 2 )/ k L a(O 2 )] were different between the 200‐L and 2000‐L bioreactors under the same P / V condition. When the agitation conditions were changed, the k L a ratio of the 2000‐L scale bioreactor became similar and the P / V value become smaller compared with those of the 200‐L SS bioreactor. The dCO 2 trends in fed‐batch cultures performed in 2000‐L scale bioreactors under the modified agitation conditions were similar to the control. This k L a ratio method was used for process development in single‐use bioreactors (SUBs) with shapes different from those of the SS bioreactor. The k L a ratios for the SUBs were evaluated and conditions that provided k L a ratios similar to the 200‐L scale SS bioreactors were determined. The cell culture performance and product quality at the end of the cultivation process were comparable for all tested SUBs. Therefore, we concluded that the k L a ratio is a powerful scale‐up factor useful to control dCO 2 during fed‐batch cultures." @default.
• W3016306699 created "2020-04-24" @default.
• W3016306699 creator A5001629306 @default.
• W3016306699 creator A5003047480 @default.
• W3016306699 creator A5016770014 @default.
• W3016306699 creator A5025911100 @default.
• W3016306699 creator A5042732704 @default.
• W3016306699 creator A5085655947 @default.
• W3016306699 date "2020-05-08" @default.
• W3016306699 modified "2023-10-18" @default.
• W3016306699 title "Development of a scale‐up strategy for Chinese hamster ovary cell culture processes using the <scp> <i>k</i> _L a </scp> ratio as a direct indicator of gas stripping conditions" @default.
• W3016306699 cites W1986944927 @default.
• W3016306699 cites W1997961774 @default.
• W3016306699 cites W2000014077 @default.
• W3016306699 cites W2004636947 @default.
• W3016306699 cites W2007180791 @default.
• W3016306699 cites W2020312136 @default.
• W3016306699 cites W2049828663 @default.
• W3016306699 cites W2122236129 @default.
• W3016306699 cites W2154593951 @default.
• W3016306699 cites W2162406947 @default.
• W3016306699 cites W2162797636 @default.
• W3016306699 cites W2168619204 @default.
• W3016306699 cites W2175291039 @default.
• W3016306699 cites W2253741797 @default.
• W3016306699 cites W2281597363 @default.
• W3016306699 cites W2324525152 @default.
• W3016306699 cites W2354242643 @default.
• W3016306699 cites W2591980198 @default.
• W3016306699 cites W2609543204 @default.
• W3016306699 cites W2758606724 @default.
• W3016306699 cites W2772049287 @default.
• W3016306699 cites W2783298268 @default.
• W3016306699 cites W2795346235 @default.
• W3016306699 cites W2802115105 @default.
• W3016306699 cites W2809294243 @default.
• W3016306699 cites W2885283829 @default.
• W3016306699 cites W2895446528 @default.
• W3016306699 cites W2907985438 @default.
• W3016306699 cites W2961306189 @default.
• W3016306699 doi "https://doi.org/10.1002/btpr.3000" @default.
• W3016306699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32298540" @default.
• W3016306699 hasPublicationYear "2020" @default.
• W3016306699 type Work @default.
• W3016306699 sameAs 3016306699 @default.
• W3016306699 citedByCount "8" @default.
• W3016306699 countsByYear W30163066992021 @default.
• W3016306699 countsByYear W30163066992022 @default.
• W3016306699 countsByYear W30163066992023 @default.
• W3016306699 crossrefType "journal-article" @default.
• W3016306699 hasAuthorship W3016306699A5001629306 @default.
• W3016306699 hasAuthorship W3016306699A5003047480 @default.
• W3016306699 hasAuthorship W3016306699A5016770014 @default.
• W3016306699 hasAuthorship W3016306699A5025911100 @default.
• W3016306699 hasAuthorship W3016306699A5042732704 @default.
• W3016306699 hasAuthorship W3016306699A5085655947 @default.
• W3016306699 hasBestOaLocation W30163066991 @default.
• W3016306699 hasConcept C121332964 @default.
• W3016306699 hasConcept C168170006 @default.
• W3016306699 hasConcept C170493617 @default.
• W3016306699 hasConcept C175656101 @default.
• W3016306699 hasConcept C178790620 @default.
• W3016306699 hasConcept C185592680 @default.
• W3016306699 hasConcept C20556612 @default.
• W3016306699 hasConcept C2777874358 @default.
• W3016306699 hasConcept C43617362 @default.
• W3016306699 hasConcept C55493867 @default.
• W3016306699 hasConcept C74650414 @default.
• W3016306699 hasConcept C97355855 @default.
• W3016306699 hasConceptScore W3016306699C121332964 @default.
• W3016306699 hasConceptScore W3016306699C168170006 @default.
• W3016306699 hasConceptScore W3016306699C170493617 @default.
• W3016306699 hasConceptScore W3016306699C175656101 @default.
• W3016306699 hasConceptScore W3016306699C178790620 @default.
• W3016306699 hasConceptScore W3016306699C185592680 @default.
• W3016306699 hasConceptScore W3016306699C20556612 @default.
• W3016306699 hasConceptScore W3016306699C2777874358 @default.
• W3016306699 hasConceptScore W3016306699C43617362 @default.
• W3016306699 hasConceptScore W3016306699C55493867 @default.
• W3016306699 hasConceptScore W3016306699C74650414 @default.
• W3016306699 hasConceptScore W3016306699C97355855 @default.
• W3016306699 hasFunder F4320320912 @default.
• W3016306699 hasIssue "5" @default.
• W3016306699 hasLocation W30163066991 @default.
• W3016306699 hasOpenAccess W3016306699 @default.
• W3016306699 hasPrimaryLocation W30163066991 @default.
• W3016306699 hasRelatedWork W155910935 @default.
• W3016306699 hasRelatedWork W1984973824 @default.
• W3016306699 hasRelatedWork W2272536808 @default.
• W3016306699 hasRelatedWork W2414194908 @default.
• W3016306699 hasRelatedWork W2835129389 @default.
• W3016306699 hasRelatedWork W2890472077 @default.
• W3016306699 hasRelatedWork W2995447656 @default.
• W3016306699 hasRelatedWork W3007675554 @default.
• W3016306699 hasRelatedWork W4212978864 @default.
• W3016306699 hasRelatedWork W4220786501 @default.
• W3016306699 hasVolume "36" @default.
• W3016306699 isParatext "false" @default.
• W3016306699 isRetracted "false" @default.
• W3016306699 magId "3016306699" @default.

• next