Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016308257> ?p ?o ?g. }
- W3016308257 endingPage "1824" @default.
- W3016308257 startingPage "1824" @default.
- W3016308257 abstract "Corticotropin (ACTH, previously an adrenocorticotropic hormone) is used in the diagnosis and treatment of pituitary gland disorders, adrenal cortex disorders, and other diseases, including autoimmune polymyositis, systemic lupus erythematosus, rheumatoid arthritis, Crohn’s disease, and ulcerative colitis. So far, the ointment dosage form containing ACTH for use on the skin is unknown. Therefore, it seems appropriate to develop a semi-solid formulation with corticotropin. Emulsion ointments were prepared using an Unguator based on the cream base Lekobaza® containing corticotropin in different concentrations, and then the physical and chemical parameters of the ointment formulations, such as pH, spreadability, rheological properties, and texture analysis, were evaluated. In addition, a USP apparatus 2 with enhancer cells was utilized to study the in vitro drug release characteristics of the selected formulations. All the ointments obtained were characterized by good spreadability and viscosity. An analysis of the ointment texture was performed and the dependence of the tested parameters on the ACTH content in the ointment was demonstrated. Examination of the structure of the ointment showed that a high concentration of ACTH increases the hardness and adhesiveness of the ointment. In turn, it adversely affects the cohesiveness and elasticity of the ointments tested. The results of the release study showed that ACTH is released the fastest from the formulation with the lowest concentration, while the slowest from the ointment with the highest concentration of ACTH." @default.
- W3016308257 created "2020-04-24" @default.
- W3016308257 creator A5060711428 @default.
- W3016308257 creator A5081718274 @default.
- W3016308257 creator A5085652809 @default.
- W3016308257 date "2020-04-16" @default.
- W3016308257 modified "2023-09-28" @default.
- W3016308257 title "Development and Study of Semi-Solid Preparations Containing the Model Substance Corticotropin (ACTH): Convenience Application in Neurodegenerative Diseases" @default.
- W3016308257 cites W1523565432 @default.
- W3016308257 cites W1585026215 @default.
- W3016308257 cites W1988879401 @default.
- W3016308257 cites W1996144411 @default.
- W3016308257 cites W1999534800 @default.
- W3016308257 cites W2003859016 @default.
- W3016308257 cites W2012502585 @default.
- W3016308257 cites W2021638902 @default.
- W3016308257 cites W2022893609 @default.
- W3016308257 cites W2028016405 @default.
- W3016308257 cites W2029455556 @default.
- W3016308257 cites W2033314099 @default.
- W3016308257 cites W2039724979 @default.
- W3016308257 cites W2054271813 @default.
- W3016308257 cites W2055353966 @default.
- W3016308257 cites W2061113234 @default.
- W3016308257 cites W2073386692 @default.
- W3016308257 cites W2079431297 @default.
- W3016308257 cites W2082126603 @default.
- W3016308257 cites W2095973327 @default.
- W3016308257 cites W2097460594 @default.
- W3016308257 cites W2120175055 @default.
- W3016308257 cites W2130218657 @default.
- W3016308257 cites W2155018873 @default.
- W3016308257 cites W2160760798 @default.
- W3016308257 cites W2160912499 @default.
- W3016308257 cites W2162853758 @default.
- W3016308257 cites W2334987143 @default.
- W3016308257 cites W2412941099 @default.
- W3016308257 cites W2532874665 @default.
- W3016308257 cites W2586288132 @default.
- W3016308257 cites W2730094282 @default.
- W3016308257 cites W2765770005 @default.
- W3016308257 cites W2773322902 @default.
- W3016308257 cites W2783343677 @default.
- W3016308257 cites W2788340071 @default.
- W3016308257 cites W2808929925 @default.
- W3016308257 cites W2912427262 @default.
- W3016308257 cites W4210396070 @default.
- W3016308257 doi "https://doi.org/10.3390/molecules25081824" @default.
- W3016308257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7222002" @default.
- W3016308257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32316183" @default.
- W3016308257 hasPublicationYear "2020" @default.
- W3016308257 type Work @default.
- W3016308257 sameAs 3016308257 @default.
- W3016308257 citedByCount "4" @default.
- W3016308257 countsByYear W30163082572020 @default.
- W3016308257 countsByYear W30163082572021 @default.
- W3016308257 countsByYear W30163082572022 @default.
- W3016308257 crossrefType "journal-article" @default.
- W3016308257 hasAuthorship W3016308257A5060711428 @default.
- W3016308257 hasAuthorship W3016308257A5081718274 @default.
- W3016308257 hasAuthorship W3016308257A5085652809 @default.
- W3016308257 hasBestOaLocation W30163082571 @default.
- W3016308257 hasConcept C126322002 @default.
- W3016308257 hasConcept C134018914 @default.
- W3016308257 hasConcept C185592680 @default.
- W3016308257 hasConcept C2777575956 @default.
- W3016308257 hasConcept C2780546910 @default.
- W3016308257 hasConcept C43617362 @default.
- W3016308257 hasConcept C71315377 @default.
- W3016308257 hasConcept C71924100 @default.
- W3016308257 hasConcept C98274493 @default.
- W3016308257 hasConceptScore W3016308257C126322002 @default.
- W3016308257 hasConceptScore W3016308257C134018914 @default.
- W3016308257 hasConceptScore W3016308257C185592680 @default.
- W3016308257 hasConceptScore W3016308257C2777575956 @default.
- W3016308257 hasConceptScore W3016308257C2780546910 @default.
- W3016308257 hasConceptScore W3016308257C43617362 @default.
- W3016308257 hasConceptScore W3016308257C71315377 @default.
- W3016308257 hasConceptScore W3016308257C71924100 @default.
- W3016308257 hasConceptScore W3016308257C98274493 @default.
- W3016308257 hasIssue "8" @default.
- W3016308257 hasLocation W30163082571 @default.
- W3016308257 hasLocation W30163082572 @default.
- W3016308257 hasLocation W30163082573 @default.
- W3016308257 hasOpenAccess W3016308257 @default.
- W3016308257 hasPrimaryLocation W30163082571 @default.
- W3016308257 hasRelatedWork W2082406232 @default.
- W3016308257 hasRelatedWork W2156283049 @default.
- W3016308257 hasRelatedWork W2316954211 @default.
- W3016308257 hasRelatedWork W2326094713 @default.
- W3016308257 hasRelatedWork W2427075784 @default.
- W3016308257 hasRelatedWork W2427452099 @default.
- W3016308257 hasRelatedWork W2748952813 @default.
- W3016308257 hasRelatedWork W2761967325 @default.
- W3016308257 hasRelatedWork W2899084033 @default.
- W3016308257 hasRelatedWork W4245782456 @default.
- W3016308257 hasVolume "25" @default.
- W3016308257 isParatext "false" @default.