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- W3016318043 abstract "The problem of treatment of oncologic patients is not resolved. Our experiments focused on the ability of autologous mesenchymal stem cells (MSCs) to inhibit glioma cell growth in vitro and in vivo. 28 thousand cells of C6 glioma in 20 μl of culture medium were stereotactically introduced into occipital region of brain (Oc2L) from the right side after craniotomy in experiments on 30 male Wistar rats weighing 250–270 g under ketamine-xylazine-acepromazine (55.6, 5.5, and 1.1 mg/kg, respectively) anesthesia. 20 rats received 400 thousand MSCs labeled with CD90s and FITC in 50 μl of culture medium under nasal mucosa during the operation. Brain slices 8 μm in thickness were prepared after decapitation of one rat from each group in one day after surgery. MSCs distribution was visualized using Zeiss AxioVert 200M fluorescence microscope with Zeiss AxioCam HRm CCD camera. Fluorescent MSCs were revealed only in damaged Oc2L area of the rat with previously injected MSCs. 10 rats from the same group (with preimplanted MSCs) received 400 thousand MSCs in 50 μl of culture medium via weekly spray injections into both nasal cavities. Rats with implanted glioma and without MSCs died in 15.0±4.3 days. Rats with implanted glioma and single intranasal MSCs injection died in 21.1±5.2 days. 8 of 10 rats that received both intranasal MSCs injection and subsequent weekly spray MSCs injections died in 33.6±3.4 days. Two rats are still alive (108 days from the date of operation). Morphological examination of brain slices of rat from the last group showed signs of apoptosis of tumor cells. It was assumed that MSCs trigger apoptosis in C6 glioma cells via paracrine way by excretion of exosomes and cytokines." @default.
- W3016318043 created "2020-04-24" @default.
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- W3016318043 date "2020-04-01" @default.
- W3016318043 modified "2023-09-26" @default.
- W3016318043 title "ANTITUMOR EFFECTS OF MESENCHYMAL STEM CELLS" @default.
- W3016318043 doi "https://doi.org/10.1096/fasebj.2020.34.s1.02700" @default.
- W3016318043 hasPublicationYear "2020" @default.
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