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- W3016319093 abstract "ABSTRACT Behaviour involves complex dynamic interactions across many brain regions. Detecting whole-brain activity in mice performing sophisticated behavioural tasks could facilitate insights into distributed processing underlying behaviour, guide local targeting, and help bridge the disparate spatial scales between rodent and human studies. Here, we present a comprehensive approach for recording brain-wide activity with functional magnetic resonance imaging (fMRI) compatible with a wide range of behavioural paradigms and neuroscience questions. We introduce hardware and procedural advances to allow multi-sensory, multi-action behavioural paradigms in the scanner. We identify signal artefacts arising from task-related body movements and propose novel strategies to reduce them. We validate and explore our approach in a 4-odour classical conditioning and a visually-guided operant task, illustrating how it can be used to extract information so far inaccessible to rodent behaviour studies. Our work paves the way for future studies combining fMRI and local circuit techniques during complex behaviour to tackle multi-scale behavioural neuroscience questions." @default.
- W3016319093 created "2020-04-24" @default.
- W3016319093 creator A5007443463 @default.
- W3016319093 creator A5007724777 @default.
- W3016319093 creator A5057632632 @default.
- W3016319093 creator A5059879166 @default.
- W3016319093 date "2020-04-18" @default.
- W3016319093 modified "2023-10-09" @default.
- W3016319093 title "Functional MRI of large scale activity in behaving mice" @default.
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