Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016337005> ?p ?o ?g. }
- W3016337005 abstract "Abstract Natural killer (NK) cells are increasingly being recognized as agents for cancer immunotherapy. KIR2DS2 is an activating killer-cell immunoglobulin-like receptor (KIR) expressed by NK cells, which has been associated with protective responses to cancer and viral infections. KIR2DS2 binds conserved viral peptides in the context of MHC class I, but to date no cancer-associated peptide ligands that bind activating KIR have been described. In order to determine if targeting KIR was a feasible strategy for mobilizing anti-cancer immune responses we established a peptide-based KIR targeting DNA vaccine. Immunizing KIR-Tg mice with the vaccine construct generated in vivo peptide-specific activation of KIR2DS2-positive NK cells leading to canonical and cross-reactive peptide specific immune responses in vitro. Using immunopeptidomics we identified the nuclear export protein XPO1, which has been associated with poor prognosis in multiple cancers, as providing an HLA-C restricted cancer-associated peptide ligand for KIR2DS2-positive NK cells. DNA vaccination of KIR-Tg mice led to both peptide specific and non-specific tumor cell killing, and protective anti-cancer responses in vivo. We thus show the feasibility of targeting KIR as a strategy that activates NK cells to generate in vivo anti-cancer immune responses, and identify XPO1 as a novel target for NK cells." @default.
- W3016337005 created "2020-04-24" @default.
- W3016337005 creator A5003903918 @default.
- W3016337005 creator A5012062502 @default.
- W3016337005 creator A5014186715 @default.
- W3016337005 creator A5020193591 @default.
- W3016337005 creator A5021251318 @default.
- W3016337005 creator A5027079457 @default.
- W3016337005 creator A5033489749 @default.
- W3016337005 creator A5042391624 @default.
- W3016337005 creator A5053276798 @default.
- W3016337005 creator A5060829193 @default.
- W3016337005 creator A5082746109 @default.
- W3016337005 creator A5087390081 @default.
- W3016337005 creator A5088201972 @default.
- W3016337005 date "2020-04-15" @default.
- W3016337005 modified "2023-09-28" @default.
- W3016337005 title "A DNA vaccine strategy to activate natural killer cells for therapeutic targeting of XPO1-positive tumors" @default.
- W3016337005 cites W1572255594 @default.
- W3016337005 cites W1675501484 @default.
- W3016337005 cites W1848101079 @default.
- W3016337005 cites W1919577144 @default.
- W3016337005 cites W1977492930 @default.
- W3016337005 cites W1982084822 @default.
- W3016337005 cites W1997714286 @default.
- W3016337005 cites W2005259908 @default.
- W3016337005 cites W2017371347 @default.
- W3016337005 cites W2017630738 @default.
- W3016337005 cites W2019855029 @default.
- W3016337005 cites W2029050898 @default.
- W3016337005 cites W2035591656 @default.
- W3016337005 cites W2085722593 @default.
- W3016337005 cites W2086042791 @default.
- W3016337005 cites W2108395794 @default.
- W3016337005 cites W2111169512 @default.
- W3016337005 cites W2112220625 @default.
- W3016337005 cites W2114104545 @default.
- W3016337005 cites W2124649657 @default.
- W3016337005 cites W2127338928 @default.
- W3016337005 cites W2132268212 @default.
- W3016337005 cites W2138781831 @default.
- W3016337005 cites W2139612810 @default.
- W3016337005 cites W2151618027 @default.
- W3016337005 cites W2159048570 @default.
- W3016337005 cites W2161027033 @default.
- W3016337005 cites W2264802194 @default.
- W3016337005 cites W2307434697 @default.
- W3016337005 cites W2363907815 @default.
- W3016337005 cites W2398303285 @default.
- W3016337005 cites W2417517756 @default.
- W3016337005 cites W2520634143 @default.
- W3016337005 cites W2526506448 @default.
- W3016337005 cites W2526904107 @default.
- W3016337005 cites W2554054889 @default.
- W3016337005 cites W2587112372 @default.
- W3016337005 cites W2587923824 @default.
- W3016337005 cites W2590945937 @default.
- W3016337005 cites W2615034605 @default.
- W3016337005 cites W2728365508 @default.
- W3016337005 cites W2754733375 @default.
- W3016337005 cites W2755626561 @default.
- W3016337005 cites W2768840488 @default.
- W3016337005 cites W2781765654 @default.
- W3016337005 cites W2784989383 @default.
- W3016337005 cites W2795441690 @default.
- W3016337005 cites W2802426007 @default.
- W3016337005 cites W2806581056 @default.
- W3016337005 cites W2885612549 @default.
- W3016337005 cites W2902856530 @default.
- W3016337005 cites W2909293804 @default.
- W3016337005 cites W2917569079 @default.
- W3016337005 cites W2923120491 @default.
- W3016337005 cites W2943286285 @default.
- W3016337005 cites W2946911529 @default.
- W3016337005 cites W2946995077 @default.
- W3016337005 cites W2952196027 @default.
- W3016337005 cites W2965427578 @default.
- W3016337005 cites W2969931905 @default.
- W3016337005 cites W2977255036 @default.
- W3016337005 hasPublicationYear "2020" @default.
- W3016337005 type Work @default.
- W3016337005 sameAs 3016337005 @default.
- W3016337005 citedByCount "0" @default.
- W3016337005 crossrefType "posted-content" @default.
- W3016337005 hasAuthorship W3016337005A5003903918 @default.
- W3016337005 hasAuthorship W3016337005A5012062502 @default.
- W3016337005 hasAuthorship W3016337005A5014186715 @default.
- W3016337005 hasAuthorship W3016337005A5020193591 @default.
- W3016337005 hasAuthorship W3016337005A5021251318 @default.
- W3016337005 hasAuthorship W3016337005A5027079457 @default.
- W3016337005 hasAuthorship W3016337005A5033489749 @default.
- W3016337005 hasAuthorship W3016337005A5042391624 @default.
- W3016337005 hasAuthorship W3016337005A5053276798 @default.
- W3016337005 hasAuthorship W3016337005A5060829193 @default.
- W3016337005 hasAuthorship W3016337005A5082746109 @default.
- W3016337005 hasAuthorship W3016337005A5087390081 @default.
- W3016337005 hasAuthorship W3016337005A5088201972 @default.
- W3016337005 hasBestOaLocation W30163370051 @default.
- W3016337005 hasConcept C121608353 @default.
- W3016337005 hasConcept C151730666 @default.