Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016340352> ?p ?o ?g. }
- W3016340352 endingPage "6026" @default.
- W3016340352 startingPage "6017" @default.
- W3016340352 abstract "Human angiotensin-converting enzyme 2 (ACE2) facilitates cellular entry of severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 as their common receptor. During infection, ACE2-expressing tissues become direct targets, resulting in serious pathological changes and progressive multiple organ failure or even death in severe cases. However, as an essential component of renin-angiotensin system (RAS), ACE2 confers protective effects in physiological circumstance, including maintaining cardiovascular homeostasis, fluid, and electrolyte balance. The absence of protective role of ACE2 leads to dysregulated RAS and thus acute changes under multiple pathological scenarios including SARS. This potentially shared mechanism may also be the molecular explanation for pathogenesis driven by SARS-CoV-2. We reasonably speculate several potential directions of clinical management including host-directed therapies aiming to restore dysregulated RAS caused by ACE2 deficiency. Enriched knowledge of ACE2 learned from SARS and COVID-19 outbreaks can provide, despite their inherent tragedy, informative clues for emerging pandemic preparedness." @default.
- W3016340352 created "2020-04-24" @default.
- W3016340352 creator A5056778600 @default.
- W3016340352 creator A5060794007 @default.
- W3016340352 creator A5061550044 @default.
- W3016340352 date "2020-04-19" @default.
- W3016340352 modified "2023-10-18" @default.
- W3016340352 title "Angiotensin‐converting enzyme 2 in severe acute respiratory syndrome coronavirus and SARS‐CoV‐2: A double‐edged sword?" @default.
- W3016340352 cites W1574929432 @default.
- W3016340352 cites W1964982019 @default.
- W3016340352 cites W1965435260 @default.
- W3016340352 cites W1966238900 @default.
- W3016340352 cites W1968279827 @default.
- W3016340352 cites W1976319679 @default.
- W3016340352 cites W1982533785 @default.
- W3016340352 cites W1993577573 @default.
- W3016340352 cites W2004555581 @default.
- W3016340352 cites W2017717619 @default.
- W3016340352 cites W2025672718 @default.
- W3016340352 cites W2025939977 @default.
- W3016340352 cites W2027259512 @default.
- W3016340352 cites W2033190476 @default.
- W3016340352 cites W2042477769 @default.
- W3016340352 cites W2068814987 @default.
- W3016340352 cites W2086853648 @default.
- W3016340352 cites W2086960330 @default.
- W3016340352 cites W2091671824 @default.
- W3016340352 cites W2103503670 @default.
- W3016340352 cites W2104899725 @default.
- W3016340352 cites W2114193904 @default.
- W3016340352 cites W2120183098 @default.
- W3016340352 cites W2143901293 @default.
- W3016340352 cites W2155438870 @default.
- W3016340352 cites W2157866223 @default.
- W3016340352 cites W2167384912 @default.
- W3016340352 cites W2511353350 @default.
- W3016340352 cites W3001118548 @default.
- W3016340352 cites W3002108456 @default.
- W3016340352 cites W3003217347 @default.
- W3016340352 cites W3004280078 @default.
- W3016340352 cites W3004318991 @default.
- W3016340352 cites W3005949806 @default.
- W3016340352 cites W3006594788 @default.
- W3016340352 cites W3007643904 @default.
- W3016340352 cites W3007940623 @default.
- W3016340352 cites W3007986422 @default.
- W3016340352 cites W3008394341 @default.
- W3016340352 cites W3008827533 @default.
- W3016340352 cites W3009906937 @default.
- W3016340352 cites W3009912996 @default.
- W3016340352 cites W3009976289 @default.
- W3016340352 cites W3012725239 @default.
- W3016340352 cites W3165656738 @default.
- W3016340352 cites W60647485 @default.
- W3016340352 doi "https://doi.org/10.1096/fj.202000782" @default.
- W3016340352 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7264803" @default.
- W3016340352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32306452" @default.
- W3016340352 hasPublicationYear "2020" @default.
- W3016340352 type Work @default.
- W3016340352 sameAs 3016340352 @default.
- W3016340352 citedByCount "86" @default.
- W3016340352 countsByYear W30163403522020 @default.
- W3016340352 countsByYear W30163403522021 @default.
- W3016340352 countsByYear W30163403522022 @default.
- W3016340352 countsByYear W30163403522023 @default.
- W3016340352 crossrefType "journal-article" @default.
- W3016340352 hasAuthorship W3016340352A5056778600 @default.
- W3016340352 hasAuthorship W3016340352A5060794007 @default.
- W3016340352 hasAuthorship W3016340352A5061550044 @default.
- W3016340352 hasBestOaLocation W30163403521 @default.
- W3016340352 hasConcept C126322002 @default.
- W3016340352 hasConcept C203014093 @default.
- W3016340352 hasConcept C2775946041 @default.
- W3016340352 hasConcept C2777648638 @default.
- W3016340352 hasConcept C2778859668 @default.
- W3016340352 hasConcept C2779134260 @default.
- W3016340352 hasConcept C2780942790 @default.
- W3016340352 hasConcept C3008058167 @default.
- W3016340352 hasConcept C524204448 @default.
- W3016340352 hasConcept C63645605 @default.
- W3016340352 hasConcept C71924100 @default.
- W3016340352 hasConceptScore W3016340352C126322002 @default.
- W3016340352 hasConceptScore W3016340352C203014093 @default.
- W3016340352 hasConceptScore W3016340352C2775946041 @default.
- W3016340352 hasConceptScore W3016340352C2777648638 @default.
- W3016340352 hasConceptScore W3016340352C2778859668 @default.
- W3016340352 hasConceptScore W3016340352C2779134260 @default.
- W3016340352 hasConceptScore W3016340352C2780942790 @default.
- W3016340352 hasConceptScore W3016340352C3008058167 @default.
- W3016340352 hasConceptScore W3016340352C524204448 @default.
- W3016340352 hasConceptScore W3016340352C63645605 @default.
- W3016340352 hasConceptScore W3016340352C71924100 @default.
- W3016340352 hasIssue "5" @default.
- W3016340352 hasLocation W30163403521 @default.
- W3016340352 hasLocation W30163403522 @default.
- W3016340352 hasLocation W30163403523 @default.
- W3016340352 hasOpenAccess W3016340352 @default.
- W3016340352 hasPrimaryLocation W30163403521 @default.