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- W3016355336 endingPage "101063" @default.
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- W3016355336 abstract "Exit from the cell cycle during the establishment of quiescence and upon cell differentiation requires the sustained inactivation of CDK complexes. Fission yeast cells deprived of nitrogen halt cell cycle progression in pre-Start G1, before becoming quiescent or undergoing sexual differentiation. The CDK inhibitor Rum1 and the APC/C activator Ste9 are fundamental for this arrest, but both are down-regulated by CDK complexes. Here, we show that PP2A-B56Par1 is instrumental for Rum1 stabilization and Ste9 activation. In the absence of PP2A-B56Par1, cells fail to accumulate Rum1, and this results in persistent CDK activity, Ste9 inactivation, retention of the mitotic cyclin Cdc13, and impaired withdrawal from the cell cycle during nitrogen starvation. Importantly, mutation of a putative B56 interacting motif in Rum1 recapitulates these defects. These results underscore the relevance of CDK-counteracting phosphatases in cell differentiation, establishment of the quiescent state, and escape from it in cancer cells." @default.
- W3016355336 created "2020-04-24" @default.
- W3016355336 creator A5040535062 @default.
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- W3016355336 creator A5081646608 @default.
- W3016355336 creator A5084673078 @default.
- W3016355336 creator A5090969032 @default.
- W3016355336 date "2020-05-01" @default.
- W3016355336 modified "2023-10-13" @default.
- W3016355336 title "Requirement of PP2A-B56Par1 for the Stabilization of the CDK Inhibitor Rum1 and Activation of APC/CSte9 during Pre-Start G1 in S. pombe" @default.
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- W3016355336 doi "https://doi.org/10.1016/j.isci.2020.101063" @default.
- W3016355336 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7195536" @default.
- W3016355336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32361273" @default.
- W3016355336 hasPublicationYear "2020" @default.
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