FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016390081> ?p ?o ?g. }

• W3016390081 endingPage "381" @default.
• W3016390081 startingPage "369" @default.
• W3016390081 abstract "Abstract Purpose The study aimed to investigate expression of epithelial-to-mesenchymal transition (EMT)-related proteins and phenotypes during breast cancer progression and to relate this to patient outcome. Methods Protein expression patterns of E-cadherin, N-cadherin, twist, and vimentin were examined by immunohistochemistry on formalin-fixed paraffin-embedded samples from primary tumors (PTs) ( n = 419), synchronous lymph node metastases (LNMs) ( n = 131) and recurrences ( n = 34) from patients included in an observational prospective primary breast cancer study. Markers were evaluated individually and combined as defined EMT phenotypes (epithelial, mesenchymal, partial EMT, and negative). EMT profiles were compared between matched tumor progression stages, and related to clinicopathological data and distant recurrence-free interval (DRFi). Results N-cadherin-positivity, vimentin-positivity, mesenchymal and partial EMT phenotypes were associated with more aggressive tumor characteristics such as triple-negative subtype. Single EMT markers and phenotype discordance rates between paired tumor samples were observed in the range of 2–35%. Non-epithelial phenotypes were more frequently identified in recurrences compared to PTs, however, no skewness of expression or phenotype was detected between PTs and matched LNMs or between PTs and matched recurrences (Exact McNemar test). Interestingly, patients with a twist positive PT had shorter DRFi, compared to patients with a twist negative PT (hazard ratio (HR) 2.4, 95% confidence interval (CI) 1.2–5.1, P = 0.02). Essentially, the same effect was seen in multivariable analysis (HR 2.5, 95% CI 0.97–6.6, P = 0.06). Conclusion The epithelial phenotype was indicated to be lost between PTs and recurrences as a reflection of tumor progression. Twist status of the PT was related to long-term prognosis warranting further investigation in larger cohorts." @default.
• W3016390081 created "2020-04-24" @default.
• W3016390081 creator A5010340306 @default.
• W3016390081 creator A5025170728 @default.
• W3016390081 creator A5030741648 @default.
• W3016390081 creator A5031679647 @default.
• W3016390081 creator A5044494492 @default.
• W3016390081 creator A5045344698 @default.
• W3016390081 creator A5059842939 @default.
• W3016390081 creator A5089541072 @default.
• W3016390081 date "2020-04-16" @default.
• W3016390081 modified "2023-10-18" @default.
• W3016390081 title "Expression of epithelial-mesenchymal transition-related markers and phenotypes during breast cancer progression" @default.
• W3016390081 cites W149191670 @default.
• W3016390081 cites W1542115364 @default.
• W3016390081 cites W1824019102 @default.
• W3016390081 cites W1908973663 @default.
• W3016390081 cites W1961026612 @default.
• W3016390081 cites W1964081206 @default.
• W3016390081 cites W1970256984 @default.
• W3016390081 cites W1996118868 @default.
• W3016390081 cites W1999042449 @default.
• W3016390081 cites W1999713483 @default.
• W3016390081 cites W2009636614 @default.
• W3016390081 cites W2028642586 @default.
• W3016390081 cites W2033498252 @default.
• W3016390081 cites W2040057855 @default.
• W3016390081 cites W2054998792 @default.
• W3016390081 cites W2069312908 @default.
• W3016390081 cites W2073618702 @default.
• W3016390081 cites W2076002185 @default.
• W3016390081 cites W2082239705 @default.
• W3016390081 cites W2102194474 @default.
• W3016390081 cites W2103232541 @default.
• W3016390081 cites W2103992634 @default.
• W3016390081 cites W2118558972 @default.
• W3016390081 cites W2138736619 @default.
• W3016390081 cites W2149504763 @default.
• W3016390081 cites W2150322923 @default.
• W3016390081 cites W2153124917 @default.
• W3016390081 cites W2157923000 @default.
• W3016390081 cites W2158013933 @default.
• W3016390081 cites W2160041578 @default.
• W3016390081 cites W2162647319 @default.
• W3016390081 cites W2164358503 @default.
• W3016390081 cites W2165469857 @default.
• W3016390081 cites W2284495907 @default.
• W3016390081 cites W2302198774 @default.
• W3016390081 cites W2325156374 @default.
• W3016390081 cites W2553654176 @default.
• W3016390081 cites W2572077158 @default.
• W3016390081 cites W2572094334 @default.
• W3016390081 cites W2586407709 @default.
• W3016390081 cites W2603666401 @default.
• W3016390081 cites W265626064 @default.
• W3016390081 cites W2736848882 @default.
• W3016390081 cites W2764073950 @default.
• W3016390081 cites W2767600184 @default.
• W3016390081 cites W2787415149 @default.
• W3016390081 cites W2789975153 @default.
• W3016390081 cites W2791623610 @default.
• W3016390081 cites W2810464703 @default.
• W3016390081 cites W2907142523 @default.
• W3016390081 cites W2909984150 @default.
• W3016390081 cites W2915478882 @default.
• W3016390081 cites W7383260 @default.
• W3016390081 doi "https://doi.org/10.1007/s10549-020-05627-0" @default.
• W3016390081 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7188722" @default.
• W3016390081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32300922" @default.
• W3016390081 hasPublicationYear "2020" @default.
• W3016390081 type Work @default.
• W3016390081 sameAs 3016390081 @default.
• W3016390081 citedByCount "22" @default.
• W3016390081 countsByYear W30163900812020 @default.
• W3016390081 countsByYear W30163900812021 @default.
• W3016390081 countsByYear W30163900812022 @default.
• W3016390081 countsByYear W30163900812023 @default.
• W3016390081 crossrefType "journal-article" @default.
• W3016390081 hasAuthorship W3016390081A5010340306 @default.
• W3016390081 hasAuthorship W3016390081A5025170728 @default.
• W3016390081 hasAuthorship W3016390081A5030741648 @default.
• W3016390081 hasAuthorship W3016390081A5031679647 @default.
• W3016390081 hasAuthorship W3016390081A5044494492 @default.
• W3016390081 hasAuthorship W3016390081A5045344698 @default.
• W3016390081 hasAuthorship W3016390081A5059842939 @default.
• W3016390081 hasAuthorship W3016390081A5089541072 @default.
• W3016390081 hasBestOaLocation W30163900811 @default.
• W3016390081 hasConcept C104317684 @default.
• W3016390081 hasConcept C121608353 @default.
• W3016390081 hasConcept C126322002 @default.
• W3016390081 hasConcept C127716648 @default.
• W3016390081 hasConcept C142724271 @default.
• W3016390081 hasConcept C143998085 @default.
• W3016390081 hasConcept C147447768 @default.
• W3016390081 hasConcept C204232928 @default.
• W3016390081 hasConcept C207103383 @default.
• W3016390081 hasConcept C2778893926 @default.
• W3016390081 hasConcept C2779013556 @default.

• next