FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016433849> ?p ?o ?g. }

• W3016433849 endingPage "148210" @default.
• W3016433849 startingPage "148210" @default.
• W3016433849 abstract "An increase in the production of reactive oxygen species (ROS) in mitochondria due to targeted delivery of redox active compounds may be useful in studies of modulation of cell functions by mitochondrial ROS. Recently, the mitochondria-targeted derivative of menadione (MitoK3) was synthesized. However, MitoK3 did not induce mitochondrial ROS production and lipid peroxidation while exerting significant cytotoxic action. Here we synthesized 1,4-naphthoquinone conjugated with alkyltriphenylphosphonium (SkQN) as a prototype of mitochondria-targeted prooxidant, and its redox properties, interactions with isolated mitochondria, yeast cells and various human cell lines were investigated. According to electrochemical measurements, SkQN was more active redox agent and, due to the absence of methyl group in the naphthoquinone ring, more reactive as electrophile than MitoK3. SkQN (but not MitoK3) stimulated hydrogen peroxide production in isolated mitochondria. At low concentrations, SkQN stimulated state 4 respiration in mitochondria, decreased membrane potential, and blocked ATP synthesis, being more efficient uncoupler of oxidative phosphorylation than MitoK3. In yeast cells, SkQN decreased cell viability and induced oxidative stress and mitochondrial fragmentation. SkQN killed various tumor cells much more efficiently than MitoK3. Since many tumors are characterized by increased oxidative stress, the use of new mitochondria-targeted prooxidants may be a promising strategy for anticancer therapy." @default.
• W3016433849 created "2020-04-24" @default.
• W3016433849 creator A5019536709 @default.
• W3016433849 creator A5041557735 @default.
• W3016433849 creator A5046295171 @default.
• W3016433849 creator A5047443167 @default.
• W3016433849 creator A5053349504 @default.
• W3016433849 creator A5055381157 @default.
• W3016433849 creator A5056155641 @default.
• W3016433849 creator A5056797689 @default.
• W3016433849 creator A5062165136 @default.
• W3016433849 creator A5068769648 @default.
• W3016433849 creator A5069370037 @default.
• W3016433849 creator A5073175877 @default.
• W3016433849 creator A5075891808 @default.
• W3016433849 creator A5082323737 @default.
• W3016433849 date "2020-08-01" @default.
• W3016433849 modified "2023-10-06" @default.
• W3016433849 title "Mitochondria-targeted 1,4-naphthoquinone (SkQN) is a powerful prooxidant and cytotoxic agent" @default.
• W3016433849 cites W1954131635 @default.
• W3016433849 cites W1982730855 @default.
• W3016433849 cites W1992423211 @default.
• W3016433849 cites W1998987657 @default.
• W3016433849 cites W2017692041 @default.
• W3016433849 cites W2028251782 @default.
• W3016433849 cites W2031172417 @default.
• W3016433849 cites W2033295134 @default.
• W3016433849 cites W2047778962 @default.
• W3016433849 cites W2060605524 @default.
• W3016433849 cites W2061728585 @default.
• W3016433849 cites W2064321590 @default.
• W3016433849 cites W2066403680 @default.
• W3016433849 cites W2067529763 @default.
• W3016433849 cites W2078532650 @default.
• W3016433849 cites W2080891051 @default.
• W3016433849 cites W2082966813 @default.
• W3016433849 cites W2083426418 @default.
• W3016433849 cites W2086783188 @default.
• W3016433849 cites W2100045865 @default.
• W3016433849 cites W2112364837 @default.
• W3016433849 cites W2118046620 @default.
• W3016433849 cites W2132270233 @default.
• W3016433849 cites W2140525205 @default.
• W3016433849 cites W2149634030 @default.
• W3016433849 cites W2161839628 @default.
• W3016433849 cites W2161859769 @default.
• W3016433849 cites W2209441369 @default.
• W3016433849 cites W2295970305 @default.
• W3016433849 cites W2335291270 @default.
• W3016433849 cites W2552484355 @default.
• W3016433849 cites W2576338535 @default.
• W3016433849 cites W2584378351 @default.
• W3016433849 cites W2596432597 @default.
• W3016433849 cites W2606684494 @default.
• W3016433849 cites W2747558158 @default.
• W3016433849 cites W2767377165 @default.
• W3016433849 cites W2767829026 @default.
• W3016433849 cites W2781472502 @default.
• W3016433849 cites W2803427102 @default.
• W3016433849 cites W2858827579 @default.
• W3016433849 cites W2898710759 @default.
• W3016433849 cites W2900505218 @default.
• W3016433849 cites W2912853526 @default.
• W3016433849 cites W2919110423 @default.
• W3016433849 cites W2971925677 @default.
• W3016433849 cites W2989291738 @default.
• W3016433849 cites W3004907850 @default.
• W3016433849 cites W370906326 @default.
• W3016433849 doi "https://doi.org/10.1016/j.bbabio.2020.148210" @default.
• W3016433849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32305410" @default.
• W3016433849 hasPublicationYear "2020" @default.
• W3016433849 type Work @default.
• W3016433849 sameAs 3016433849 @default.
• W3016433849 citedByCount "11" @default.
• W3016433849 countsByYear W30164338492021 @default.
• W3016433849 countsByYear W30164338492022 @default.
• W3016433849 countsByYear W30164338492023 @default.
• W3016433849 crossrefType "journal-article" @default.
• W3016433849 hasAuthorship W3016433849A5019536709 @default.
• W3016433849 hasAuthorship W3016433849A5041557735 @default.
• W3016433849 hasAuthorship W3016433849A5046295171 @default.
• W3016433849 hasAuthorship W3016433849A5047443167 @default.
• W3016433849 hasAuthorship W3016433849A5053349504 @default.
• W3016433849 hasAuthorship W3016433849A5055381157 @default.
• W3016433849 hasAuthorship W3016433849A5056155641 @default.
• W3016433849 hasAuthorship W3016433849A5056797689 @default.
• W3016433849 hasAuthorship W3016433849A5062165136 @default.
• W3016433849 hasAuthorship W3016433849A5068769648 @default.
• W3016433849 hasAuthorship W3016433849A5069370037 @default.
• W3016433849 hasAuthorship W3016433849A5073175877 @default.
• W3016433849 hasAuthorship W3016433849A5075891808 @default.
• W3016433849 hasAuthorship W3016433849A5082323737 @default.
• W3016433849 hasBestOaLocation W30164338491 @default.
• W3016433849 hasConcept C185592680 @default.
• W3016433849 hasConcept C2776151105 @default.
• W3016433849 hasConcept C2780829032 @default.
• W3016433849 hasConcept C2781095387 @default.
• W3016433849 hasConcept C28859421 @default.

• next