FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016457236> ?p ?o ?g. }

• W3016457236 endingPage "1934578X2090917" @default.
• W3016457236 startingPage "1934578X2090917" @default.
• W3016457236 abstract "Spiroacetals are the central structural core element of numerous natural products and are essential for their biological activity. A typical structural representative of a spiroacetal is the bicyclic 1,6-dioxaspiro[4.5]decane ring system. It represents the complete or partial structure of many biologically potent natural products such as the Paravespula pheromone 1, the antibiotic (+)-monensin A 2, the anticancer agent (−)-berkelic acid 3, the antimitotic ingredient spirastrellolide F, characterized after methylation as (+)-methyl ester 4, and the marine toxin (−)-calyculin A 5. In these compounds, the 1,6-dioxaspiro[4.5]decane ring system is found in either spiro ( R)-6 or ( S) - 6 configuration. The corresponding 1,6,9-trioxaspiro[4.5]decane framework ( S)-7 and ( R)-7 with opposite chirality at the spiro center due to an additional oxygen atom at position 9 in the pyran portion has so far not been found in living organisms or been synthesized. To close this gap and enable structure–activity relationship studies, potentially leading to novel antibiotics and selective anticancer agents, we have developed an efficient and stereocontrolled route to the ( R)- and ( S)-configurated 1,6,9-trioxaspiro[4.5]decane ring system leading to oxa analog motifs of the above natural products." @default.
• W3016457236 created "2020-04-24" @default.
• W3016457236 creator A5016530309 @default.
• W3016457236 date "2020-04-01" @default.
• W3016457236 modified "2023-10-12" @default.
• W3016457236 title "Stereoselective Synthesis of 1,6,9-Tri-oxaspiro[4.5]decanes From <scp>d</scp>-Glucose: Novel Structural Motifs of Spiroacetal Natural Products" @default.
• W3016457236 cites W1964485660 @default.
• W3016457236 cites W1968408952 @default.
• W3016457236 cites W1973847774 @default.
• W3016457236 cites W1987928599 @default.
• W3016457236 cites W1992567311 @default.
• W3016457236 cites W1992585644 @default.
• W3016457236 cites W1994307730 @default.
• W3016457236 cites W1995102412 @default.
• W3016457236 cites W1996109003 @default.
• W3016457236 cites W2004635162 @default.
• W3016457236 cites W2004814798 @default.
• W3016457236 cites W2006009538 @default.
• W3016457236 cites W2006366687 @default.
• W3016457236 cites W2013705423 @default.
• W3016457236 cites W2017644533 @default.
• W3016457236 cites W2025590935 @default.
• W3016457236 cites W2029526231 @default.
• W3016457236 cites W2030641570 @default.
• W3016457236 cites W2033501395 @default.
• W3016457236 cites W2035225225 @default.
• W3016457236 cites W2038263763 @default.
• W3016457236 cites W2039916209 @default.
• W3016457236 cites W2042760452 @default.
• W3016457236 cites W2051080375 @default.
• W3016457236 cites W2051656036 @default.
• W3016457236 cites W2057889936 @default.
• W3016457236 cites W2059995190 @default.
• W3016457236 cites W2067244774 @default.
• W3016457236 cites W2070844920 @default.
• W3016457236 cites W2074945007 @default.
• W3016457236 cites W2095310362 @default.
• W3016457236 cites W2103694930 @default.
• W3016457236 cites W2105879297 @default.
• W3016457236 cites W2110506537 @default.
• W3016457236 cites W2117382029 @default.
• W3016457236 cites W2120143110 @default.
• W3016457236 cites W2120965192 @default.
• W3016457236 cites W2131385621 @default.
• W3016457236 cites W2132238532 @default.
• W3016457236 cites W2140559850 @default.
• W3016457236 cites W2141044984 @default.
• W3016457236 cites W2144586125 @default.
• W3016457236 cites W2152158556 @default.
• W3016457236 cites W2154243294 @default.
• W3016457236 cites W2154452160 @default.
• W3016457236 cites W2158338661 @default.
• W3016457236 cites W2291772488 @default.
• W3016457236 cites W2332639813 @default.
• W3016457236 cites W2526433666 @default.
• W3016457236 cites W2606423759 @default.
• W3016457236 cites W2782732743 @default.
• W3016457236 cites W2801817759 @default.
• W3016457236 cites W2949809171 @default.
• W3016457236 cites W2950598269 @default.
• W3016457236 cites W2951406193 @default.
• W3016457236 cites W4211180255 @default.
• W3016457236 doi "https://doi.org/10.1177/1934578x20909175" @default.
• W3016457236 hasPublicationYear "2020" @default.
• W3016457236 type Work @default.
• W3016457236 sameAs 3016457236 @default.
• W3016457236 citedByCount "1" @default.
• W3016457236 countsByYear W30164572362023 @default.
• W3016457236 crossrefType "journal-article" @default.
• W3016457236 hasAuthorship W3016457236A5016530309 @default.
• W3016457236 hasBestOaLocation W30164572361 @default.
• W3016457236 hasConcept C178790620 @default.
• W3016457236 hasConcept C185592680 @default.
• W3016457236 hasConcept C2776981874 @default.
• W3016457236 hasConcept C2777505907 @default.
• W3016457236 hasConcept C2779396153 @default.
• W3016457236 hasConcept C2780378348 @default.
• W3016457236 hasConcept C35753019 @default.
• W3016457236 hasConcept C71240020 @default.
• W3016457236 hasConceptScore W3016457236C178790620 @default.
• W3016457236 hasConceptScore W3016457236C185592680 @default.
• W3016457236 hasConceptScore W3016457236C2776981874 @default.
• W3016457236 hasConceptScore W3016457236C2777505907 @default.
• W3016457236 hasConceptScore W3016457236C2779396153 @default.
• W3016457236 hasConceptScore W3016457236C2780378348 @default.
• W3016457236 hasConceptScore W3016457236C35753019 @default.
• W3016457236 hasConceptScore W3016457236C71240020 @default.
• W3016457236 hasIssue "4" @default.
• W3016457236 hasLocation W30164572361 @default.
• W3016457236 hasOpenAccess W3016457236 @default.
• W3016457236 hasPrimaryLocation W30164572361 @default.
• W3016457236 hasRelatedWork W1985649844 @default.
• W3016457236 hasRelatedWork W2056969490 @default.
• W3016457236 hasRelatedWork W2062897035 @default.
• W3016457236 hasRelatedWork W2160560604 @default.
• W3016457236 hasRelatedWork W2321885497 @default.
• W3016457236 hasRelatedWork W2951580943 @default.
• W3016457236 hasRelatedWork W2952017530 @default.

• next