FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016520003> ?p ?o ?g. }

• W3016520003 abstract "Abstract Background Human immunodeficiency virus (HIV) infection leads to blood–brain barrier (BBB) dysfunction that does not resolve despite viral suppression on antiretroviral therapy (ART) and is associated with adverse clinical outcomes. In preclinical models, cannabis restores BBB integrity. Methods We studied persons with HIV (PWH) and HIV-negative (HIV−) individuals who had used cannabis recently. We assessed 2 biomarkers of BBB permeability: the cerebrospinal fluid (CSF) to serum albumin ratio (CSAR) and CSF levels of soluble urokinase plasminogen activator receptor (suPAR), a receptor for uPA, a matrix-degrading proteolytic enzyme that disrupts the BBB. A composite index of the BBB markers was created using principal components analysis. Neural injury was assessed using neurofilament light (NFL) in CSF by immunoassay. Results Participants were 45 PWH and 30 HIV− individuals of similar age and ethnicity. Among PWH, higher CSF suPAR levels correlated with higher CSAR values (r = 0.47, P &lt; .001). PWH had higher (more abnormal) BBB index values than HIV− individuals (mean ± SD, 0.361 ± 1.20 vs −0.501 ± 1.11; P = .0214). HIV serostatus interacted with cannabis use frequency, such that more frequent use of cannabis was associated with lower BBB index values in PWH but not in HIV− individuals. Worse BBB index values were associated with higher NFL in CSF (r = 0.380, P = .0169). Conclusions Cannabis may have a beneficial impact on HIV-associated BBB injury. Since BBB disruption may permit increased entry of toxins such as microbial antigens and inflammatory mediators, with consequent CNS injury, these results support a potential therapeutic role of cannabis among PWH and may have important treatment implications for ART effectiveness and toxicity." @default.
• W3016520003 created "2020-04-24" @default.
• W3016520003 creator A5025633711 @default.
• W3016520003 creator A5028748234 @default.
• W3016520003 creator A5030691410 @default.
• W3016520003 creator A5037376197 @default.
• W3016520003 creator A5039415314 @default.
• W3016520003 creator A5053349718 @default.
• W3016520003 creator A5060121384 @default.
• W3016520003 creator A5063654181 @default.
• W3016520003 creator A5076723396 @default.
• W3016520003 date "2020-04-16" @default.
• W3016520003 modified "2023-10-12" @default.
• W3016520003 title "Beneficial Effects of Cannabis on Blood–Brain Barrier Function in Human Immunodeficiency Virus" @default.
• W3016520003 cites W1207024929 @default.
• W3016520003 cites W1907946315 @default.
• W3016520003 cites W1924866649 @default.
• W3016520003 cites W1950910266 @default.
• W3016520003 cites W1975492163 @default.
• W3016520003 cites W1977834089 @default.
• W3016520003 cites W1980085014 @default.
• W3016520003 cites W1990913669 @default.
• W3016520003 cites W1997874814 @default.
• W3016520003 cites W2015943785 @default.
• W3016520003 cites W2038161589 @default.
• W3016520003 cites W2043268426 @default.
• W3016520003 cites W2050459488 @default.
• W3016520003 cites W2058566642 @default.
• W3016520003 cites W2065033340 @default.
• W3016520003 cites W2072422429 @default.
• W3016520003 cites W2085323816 @default.
• W3016520003 cites W2105249237 @default.
• W3016520003 cites W2110003018 @default.
• W3016520003 cites W2111152176 @default.
• W3016520003 cites W2129219544 @default.
• W3016520003 cites W2141163306 @default.
• W3016520003 cites W2151690085 @default.
• W3016520003 cites W2156649357 @default.
• W3016520003 cites W2180292573 @default.
• W3016520003 cites W2254253852 @default.
• W3016520003 cites W2302288817 @default.
• W3016520003 cites W2407578345 @default.
• W3016520003 cites W2513043545 @default.
• W3016520003 cites W2554001657 @default.
• W3016520003 cites W2555145513 @default.
• W3016520003 cites W2555906375 @default.
• W3016520003 cites W2561976637 @default.
• W3016520003 cites W2563325297 @default.
• W3016520003 cites W2603365112 @default.
• W3016520003 cites W2724419264 @default.
• W3016520003 cites W2789742968 @default.
• W3016520003 cites W2799404730 @default.
• W3016520003 cites W2805607034 @default.
• W3016520003 cites W2900541949 @default.
• W3016520003 cites W2962214041 @default.
• W3016520003 cites W3193259242 @default.
• W3016520003 cites W4213186691 @default.
• W3016520003 cites W908901015 @default.
• W3016520003 doi "https://doi.org/10.1093/cid/ciaa437" @default.
• W3016520003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8246839" @default.
• W3016520003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32296832" @default.
• W3016520003 hasPublicationYear "2020" @default.
• W3016520003 type Work @default.
• W3016520003 sameAs 3016520003 @default.
• W3016520003 citedByCount "19" @default.
• W3016520003 countsByYear W30165200032020 @default.
• W3016520003 countsByYear W30165200032021 @default.
• W3016520003 countsByYear W30165200032022 @default.
• W3016520003 countsByYear W30165200032023 @default.
• W3016520003 crossrefType "journal-article" @default.
• W3016520003 hasAuthorship W3016520003A5025633711 @default.
• W3016520003 hasAuthorship W3016520003A5028748234 @default.
• W3016520003 hasAuthorship W3016520003A5030691410 @default.
• W3016520003 hasAuthorship W3016520003A5037376197 @default.
• W3016520003 hasAuthorship W3016520003A5039415314 @default.
• W3016520003 hasAuthorship W3016520003A5053349718 @default.
• W3016520003 hasAuthorship W3016520003A5060121384 @default.
• W3016520003 hasAuthorship W3016520003A5063654181 @default.
• W3016520003 hasAuthorship W3016520003A5076723396 @default.
• W3016520003 hasBestOaLocation W30165200032 @default.
• W3016520003 hasConcept C118552586 @default.
• W3016520003 hasConcept C126322002 @default.
• W3016520003 hasConcept C142462285 @default.
• W3016520003 hasConcept C197934379 @default.
• W3016520003 hasConcept C203014093 @default.
• W3016520003 hasConcept C2776535787 @default.
• W3016520003 hasConcept C2777056318 @default.
• W3016520003 hasConcept C2778402981 @default.
• W3016520003 hasConcept C3013748606 @default.
• W3016520003 hasConcept C529278444 @default.
• W3016520003 hasConcept C71924100 @default.
• W3016520003 hasConceptScore W3016520003C118552586 @default.
• W3016520003 hasConceptScore W3016520003C126322002 @default.
• W3016520003 hasConceptScore W3016520003C142462285 @default.
• W3016520003 hasConceptScore W3016520003C197934379 @default.
• W3016520003 hasConceptScore W3016520003C203014093 @default.
• W3016520003 hasConceptScore W3016520003C2776535787 @default.
• W3016520003 hasConceptScore W3016520003C2777056318 @default.
• W3016520003 hasConceptScore W3016520003C2778402981 @default.
• W3016520003 hasConceptScore W3016520003C3013748606 @default.

• next