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• W3016521585 endingPage "e0231356" @default.
• W3016521585 startingPage "e0231356" @default.
• W3016521585 abstract "The ancestor of most teleost fishes underwent a whole-genome duplication event three hundred million years ago. Despite its antiquity, the effects of this event are evident both in the structure of teleost genomes and in how the surviving duplicated genes still operate to drive form and function. I inferred a set of shared syntenic regions that survive from the teleost genome duplication (TGD) using eight teleost genomes and the outgroup gar genome (which lacks the TGD). I then phylogenetically modeled the TGD’s resolution via shared and independent gene losses and applied a new simulation-based statistical test for the presence of bias toward the preservation of genes from one parental subgenome. On the basis of that test, I argue that the TGD was likely an allopolyploidy. I find that duplicate genes surviving from this duplication in zebrafish are less likely to function in early embryo development than are genes that have returned to single copy at some point in this species’ history. The tissues these ohnologs are expressed in, as well as their biological functions, lend support to recent suggestions that the TGD was the source of a morphological innovation in the structure of the teleost retina. Surviving duplicates also appear less likely to be essential than singletons, despite the fact that their single-copy orthologs in mouse are no less essential than other genes." @default.
• W3016521585 created "2020-04-24" @default.
• W3016521585 creator A5041114077 @default.
• W3016521585 date "2020-04-16" @default.
• W3016521585 modified "2023-10-17" @default.
• W3016521585 title "The lasting after-effects of an ancient polyploidy on the genomes of teleosts" @default.
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