Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016532017> ?p ?o ?g. }
- W3016532017 endingPage "43" @default.
- W3016532017 startingPage "34" @default.
- W3016532017 abstract "The nuclease activity of deoxyribonuclease 1 (DNase I) is regulated by alternative splicing (AS) of its mRNA. The aim of this study was to define the ability of a splice-switching oligonucleotide (SSO) that base-paired with DNase I pre-mRNA to induce AS and inhibit nuclease activity in human T, B and NK lymphocytes. The SSO for DNase I could significantly downregulate the expression of full-length active DNase I and upregulate a truncated splice variant with a deleted exon 4. Such an induction of AS resulted in inhibition of nuclease activity and slowed apoptosis progression in anti-CD95/FAS stimulated lymphocytes. These results should facilitate further investigations of apoptosis regulation in lymphocytes and demonstrate that SSOs for DNase I are promising cytoprotective agents." @default.
- W3016532017 created "2020-04-24" @default.
- W3016532017 creator A5015709348 @default.
- W3016532017 creator A5027431619 @default.
- W3016532017 creator A5048857257 @default.
- W3016532017 creator A5056596689 @default.
- W3016532017 creator A5069498141 @default.
- W3016532017 creator A5070671714 @default.
- W3016532017 creator A5084227909 @default.
- W3016532017 date "2020-07-01" @default.
- W3016532017 modified "2023-10-13" @default.
- W3016532017 title "Inhibition of nuclease activity by a splice-switching oligonucleotide targeting deoxyribonuclease 1 mRNA prevents apoptosis progression and prolong viability of normal human CD4+ T-lymphocytes" @default.
- W3016532017 cites W1480948328 @default.
- W3016532017 cites W1481702065 @default.
- W3016532017 cites W1532302462 @default.
- W3016532017 cites W1567114372 @default.
- W3016532017 cites W1967064362 @default.
- W3016532017 cites W1980462656 @default.
- W3016532017 cites W1986572373 @default.
- W3016532017 cites W1991711413 @default.
- W3016532017 cites W2007105011 @default.
- W3016532017 cites W2026657651 @default.
- W3016532017 cites W2032177235 @default.
- W3016532017 cites W2042141743 @default.
- W3016532017 cites W2049259928 @default.
- W3016532017 cites W2052817130 @default.
- W3016532017 cites W2093648385 @default.
- W3016532017 cites W2094875875 @default.
- W3016532017 cites W2095468287 @default.
- W3016532017 cites W2097699954 @default.
- W3016532017 cites W2100837269 @default.
- W3016532017 cites W2102337459 @default.
- W3016532017 cites W2106767328 @default.
- W3016532017 cites W2132508967 @default.
- W3016532017 cites W2206302984 @default.
- W3016532017 cites W2237506108 @default.
- W3016532017 cites W2271292156 @default.
- W3016532017 cites W2523305068 @default.
- W3016532017 cites W2579408146 @default.
- W3016532017 cites W2596267980 @default.
- W3016532017 cites W2727136251 @default.
- W3016532017 cites W2751544109 @default.
- W3016532017 cites W2792381679 @default.
- W3016532017 cites W2884284961 @default.
- W3016532017 cites W2902100266 @default.
- W3016532017 cites W2916464185 @default.
- W3016532017 cites W2952060487 @default.
- W3016532017 cites W4244307524 @default.
- W3016532017 doi "https://doi.org/10.1016/j.biochi.2020.04.009" @default.
- W3016532017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32315661" @default.
- W3016532017 hasPublicationYear "2020" @default.
- W3016532017 type Work @default.
- W3016532017 sameAs 3016532017 @default.
- W3016532017 citedByCount "1" @default.
- W3016532017 countsByYear W30165320172022 @default.
- W3016532017 crossrefType "journal-article" @default.
- W3016532017 hasAuthorship W3016532017A5015709348 @default.
- W3016532017 hasAuthorship W3016532017A5027431619 @default.
- W3016532017 hasAuthorship W3016532017A5048857257 @default.
- W3016532017 hasAuthorship W3016532017A5056596689 @default.
- W3016532017 hasAuthorship W3016532017A5069498141 @default.
- W3016532017 hasAuthorship W3016532017A5070671714 @default.
- W3016532017 hasAuthorship W3016532017A5084227909 @default.
- W3016532017 hasConcept C104317684 @default.
- W3016532017 hasConcept C105580179 @default.
- W3016532017 hasConcept C127561419 @default.
- W3016532017 hasConcept C129312508 @default.
- W3016532017 hasConcept C153911025 @default.
- W3016532017 hasConcept C182614070 @default.
- W3016532017 hasConcept C190283241 @default.
- W3016532017 hasConcept C194583182 @default.
- W3016532017 hasConcept C2777271071 @default.
- W3016532017 hasConcept C2778659741 @default.
- W3016532017 hasConcept C2779377703 @default.
- W3016532017 hasConcept C3017666073 @default.
- W3016532017 hasConcept C3031857 @default.
- W3016532017 hasConcept C31573885 @default.
- W3016532017 hasConcept C36823959 @default.
- W3016532017 hasConcept C54458228 @default.
- W3016532017 hasConcept C552990157 @default.
- W3016532017 hasConcept C55493867 @default.
- W3016532017 hasConcept C58237431 @default.
- W3016532017 hasConcept C67705224 @default.
- W3016532017 hasConcept C86803240 @default.
- W3016532017 hasConcept C95444343 @default.
- W3016532017 hasConceptScore W3016532017C104317684 @default.
- W3016532017 hasConceptScore W3016532017C105580179 @default.
- W3016532017 hasConceptScore W3016532017C127561419 @default.
- W3016532017 hasConceptScore W3016532017C129312508 @default.
- W3016532017 hasConceptScore W3016532017C153911025 @default.
- W3016532017 hasConceptScore W3016532017C182614070 @default.
- W3016532017 hasConceptScore W3016532017C190283241 @default.
- W3016532017 hasConceptScore W3016532017C194583182 @default.
- W3016532017 hasConceptScore W3016532017C2777271071 @default.
- W3016532017 hasConceptScore W3016532017C2778659741 @default.
- W3016532017 hasConceptScore W3016532017C2779377703 @default.
- W3016532017 hasConceptScore W3016532017C3017666073 @default.
- W3016532017 hasConceptScore W3016532017C3031857 @default.