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- W3016557714 abstract "Cisplatin is an antineoplastic drug administered at suboptimal and intermittent doses to avoid life-threatening effects. Although this regimen shortly improves symptoms in the short term, it also leads to more malignant disease in the long term. We describe a multilayered analysis ranging from chromatin to translation—integrating chromatin immunoprecipitation sequencing (ChIP-seq), global run-on sequencing (GRO-seq), RNA sequencing (RNA-seq), and ribosome profiling—to understand how cisplatin confers (pre)malignant features by using a well-established ovarian cancer model of cisplatin exposure. This approach allows us to segregate the human transcriptome into gene modules representing distinct regulatory principles and to characterize that the most cisplatin-disrupted modules are associated with underlying events of super-enhancer plasticity. These events arise when cancer cells initiate without ultimately ending the program of drug-stimulated death. Using a PageRank-based algorithm, we predict super-enhancer regulator ISL1 as a driver of this plasticity and validate this prediction by using CRISPR/dCas9-KRAB inhibition (CRISPRi) and CRISPR/dCas9-VP64 activation (CRISPRa) tools. Together, we propose that cisplatin reprograms cancer cells when inducing them to undergo near-to-death experiences." @default.
- W3016557714 created "2020-04-24" @default.
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- W3016557714 date "2020-04-01" @default.
- W3016557714 modified "2023-10-14" @default.
- W3016557714 title "Super-Enhancer Redistribution as a Mechanism of Broad Gene Dysregulation in Repeatedly Drug-Treated Cancer Cells" @default.
- W3016557714 cites W1490897532 @default.
- W3016557714 cites W1498988665 @default.
- W3016557714 cites W1938080407 @default.
- W3016557714 cites W1963594713 @default.
- W3016557714 cites W1969158270 @default.
- W3016557714 cites W1971578941 @default.
- W3016557714 cites W1976731741 @default.
- W3016557714 cites W1981974167 @default.
- W3016557714 cites W1987835971 @default.
- W3016557714 cites W1990781055 @default.
- W3016557714 cites W1995103178 @default.
- W3016557714 cites W1996060670 @default.
- W3016557714 cites W1997338647 @default.
- W3016557714 cites W1999555459 @default.
- W3016557714 cites W2002424170 @default.
- W3016557714 cites W2004966039 @default.
- W3016557714 cites W2009033332 @default.
- W3016557714 cites W2014677321 @default.
- W3016557714 cites W2015009944 @default.
- W3016557714 cites W2015030879 @default.
- W3016557714 cites W2016226316 @default.
- W3016557714 cites W2017840637 @default.
- W3016557714 cites W2021973292 @default.
- W3016557714 cites W2025669441 @default.
- W3016557714 cites W2032091934 @default.
- W3016557714 cites W2040882656 @default.
- W3016557714 cites W2041434532 @default.
- W3016557714 cites W2042619042 @default.
- W3016557714 cites W2043469010 @default.
- W3016557714 cites W2058200628 @default.
- W3016557714 cites W2060484997 @default.
- W3016557714 cites W2064442490 @default.
- W3016557714 cites W2068136170 @default.
- W3016557714 cites W2073688125 @default.
- W3016557714 cites W2075214050 @default.
- W3016557714 cites W2089914632 @default.
- W3016557714 cites W2092182701 @default.
- W3016557714 cites W2095799855 @default.
- W3016557714 cites W2104224322 @default.
- W3016557714 cites W2106391833 @default.
- W3016557714 cites W2117026298 @default.
- W3016557714 cites W2123511606 @default.
- W3016557714 cites W2124238367 @default.
- W3016557714 cites W2126271676 @default.
- W3016557714 cites W2127862779 @default.
- W3016557714 cites W2131752445 @default.
- W3016557714 cites W2141571283 @default.
- W3016557714 cites W2150170782 @default.
- W3016557714 cites W2151522898 @default.
- W3016557714 cites W2154077612 @default.
- W3016557714 cites W2156441552 @default.
- W3016557714 cites W2159515687 @default.
- W3016557714 cites W2169389191 @default.
- W3016557714 cites W2170259055 @default.
- W3016557714 cites W2171236700 @default.
- W3016557714 cites W2259938310 @default.
- W3016557714 cites W2339938878 @default.
- W3016557714 cites W2341763698 @default.
- W3016557714 cites W2439807060 @default.
- W3016557714 cites W2526788217 @default.
- W3016557714 cites W2561012755 @default.
- W3016557714 cites W2581196019 @default.
- W3016557714 cites W2586373162 @default.
- W3016557714 cites W2597268880 @default.
- W3016557714 cites W2606796272 @default.
- W3016557714 cites W2607363971 @default.
- W3016557714 cites W2621895366 @default.
- W3016557714 cites W2737272162 @default.
- W3016557714 cites W2765438409 @default.
- W3016557714 cites W2767582236 @default.
- W3016557714 cites W2769426045 @default.
- W3016557714 cites W2785797026 @default.
- W3016557714 cites W2794480084 @default.
- W3016557714 cites W2797844455 @default.
- W3016557714 cites W2886621724 @default.
- W3016557714 cites W2891731547 @default.
- W3016557714 cites W2903308832 @default.
- W3016557714 cites W2908832432 @default.
- W3016557714 cites W2942987360 @default.
- W3016557714 cites W2947430754 @default.