FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016565981> ?p ?o ?g. }

• W3016565981 endingPage "e0231472" @default.
• W3016565981 startingPage "e0231472" @default.
• W3016565981 abstract "Oxidative stress is involved in the pathogenesis of a number of diseases including hypertension and renal failure. There is enhanced expression of nicotinamide adenine dinucleotide (NADPH oxidase) and therefore production of hydrogen peroxide (H2O2) during renal disease progression. This study investigated the effect of apocynin, an NADPH oxidase inhibitor and catalase, an H2O2 scavenger on Cyclosporine A (CsA) nephrotoxicity in Wistar-Kyoto rats. Rats received CsA (25mg/kg/day via gavage) and were assigned to vehicle, apocynin (2.5mmol/L p.o.), catalase (10,000U/kg/day i.p.) or apocynin plus catalase for 14 days. Renal functional and hemodynamic parameters were measured every week, and kidneys were harvested at the end of the study for histological and NADPH oxidase 4 (NOX4) assessment. Oxidative stress markers and blood urea nitrogen (BUN) were measured. CsA rats had higher plasma malondialdehyde (by 340%) and BUN (by 125%), but lower superoxide dismutase and total antioxidant capacity (by 40%, all P<0.05) compared to control. CsA increased blood pressure (by 46mmHg) and decreased creatinine clearance (by 49%, all P<0.05). Treatment of CsA rats with apocynin, catalase, and their combination decreased blood pressure to near control values (all P<0.05). NOX4 mRNA activity was higher in the renal tissue of CsA rats by approximately 63% (P<0.05) compared to controls but was reduced in apocynin (by 64%), catalase (by 33%) and combined treatment with apocynin and catalase (by 84%) compared to untreated CsA rats. Treatment of CsA rats with apocynin, catalase, and their combination prevented hypertension and restored renal functional parameters and tissue Nox4 expression in this model. NADPH inhibition and H2O2 scavenging is an important therapeutic strategy during CsA nephrotoxicity and hypertension." @default.
• W3016565981 created "2020-04-24" @default.
• W3016565981 creator A5001287974 @default.
• W3016565981 creator A5003366258 @default.
• W3016565981 creator A5010778183 @default.
• W3016565981 creator A5025720471 @default.
• W3016565981 creator A5034072237 @default.
• W3016565981 creator A5051504482 @default.
• W3016565981 creator A5063985624 @default.
• W3016565981 creator A5080705880 @default.
• W3016565981 creator A5085699651 @default.
• W3016565981 creator A5089016927 @default.
• W3016565981 date "2020-04-16" @default.
• W3016565981 modified "2023-09-23" @default.
• W3016565981 title "Apocynin and catalase prevent hypertension and kidney injury in Cyclosporine A-induced nephrotoxicity in rats" @default.
• W3016565981 cites W1500310566 @default.
• W3016565981 cites W1893990936 @default.
• W3016565981 cites W1929253030 @default.
• W3016565981 cites W1940471034 @default.
• W3016565981 cites W1947666932 @default.
• W3016565981 cites W1961179371 @default.
• W3016565981 cites W1972549253 @default.
• W3016565981 cites W1974683714 @default.
• W3016565981 cites W1976255839 @default.
• W3016565981 cites W1981921279 @default.
• W3016565981 cites W1983310681 @default.
• W3016565981 cites W1990921191 @default.
• W3016565981 cites W1993599355 @default.
• W3016565981 cites W1998089491 @default.
• W3016565981 cites W2009230048 @default.
• W3016565981 cites W2017057079 @default.
• W3016565981 cites W2021350420 @default.
• W3016565981 cites W2026679278 @default.
• W3016565981 cites W2034463708 @default.
• W3016565981 cites W2049739776 @default.
• W3016565981 cites W2060979359 @default.
• W3016565981 cites W2063430855 @default.
• W3016565981 cites W2064618711 @default.
• W3016565981 cites W2064854813 @default.
• W3016565981 cites W2083245473 @default.
• W3016565981 cites W2084471334 @default.
• W3016565981 cites W2084744910 @default.
• W3016565981 cites W2086306762 @default.
• W3016565981 cites W2090230494 @default.
• W3016565981 cites W2097842591 @default.
• W3016565981 cites W2098945680 @default.
• W3016565981 cites W2099442941 @default.
• W3016565981 cites W2099874386 @default.
• W3016565981 cites W2101017545 @default.
• W3016565981 cites W2101937547 @default.
• W3016565981 cites W2105940831 @default.
• W3016565981 cites W2114879832 @default.
• W3016565981 cites W2114999110 @default.
• W3016565981 cites W2118837595 @default.
• W3016565981 cites W2122320473 @default.
• W3016565981 cites W2123123601 @default.
• W3016565981 cites W2130904954 @default.
• W3016565981 cites W2134672034 @default.
• W3016565981 cites W2134819303 @default.
• W3016565981 cites W2136728678 @default.
• W3016565981 cites W2137073289 @default.
• W3016565981 cites W2137730916 @default.
• W3016565981 cites W2138423356 @default.
• W3016565981 cites W2139869978 @default.
• W3016565981 cites W2140498802 @default.
• W3016565981 cites W2148474886 @default.
• W3016565981 cites W2149087906 @default.
• W3016565981 cites W2156909950 @default.
• W3016565981 cites W2162514162 @default.
• W3016565981 cites W2165098078 @default.
• W3016565981 cites W2166479568 @default.
• W3016565981 cites W2166838509 @default.
• W3016565981 cites W2170293969 @default.
• W3016565981 cites W2295001036 @default.
• W3016565981 cites W2738418450 @default.
• W3016565981 cites W2791471224 @default.
• W3016565981 cites W2980460691 @default.
• W3016565981 cites W4255377991 @default.
• W3016565981 doi "https://doi.org/10.1371/journal.pone.0231472" @default.
• W3016565981 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7161975" @default.
• W3016565981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32298299" @default.
• W3016565981 hasPublicationYear "2020" @default.
• W3016565981 type Work @default.
• W3016565981 sameAs 3016565981 @default.
• W3016565981 citedByCount "14" @default.
• W3016565981 countsByYear W30165659812020 @default.
• W3016565981 countsByYear W30165659812021 @default.
• W3016565981 countsByYear W30165659812022 @default.
• W3016565981 countsByYear W30165659812023 @default.
• W3016565981 crossrefType "journal-article" @default.
• W3016565981 hasAuthorship W3016565981A5001287974 @default.
• W3016565981 hasAuthorship W3016565981A5003366258 @default.
• W3016565981 hasAuthorship W3016565981A5010778183 @default.
• W3016565981 hasAuthorship W3016565981A5025720471 @default.
• W3016565981 hasAuthorship W3016565981A5034072237 @default.
• W3016565981 hasAuthorship W3016565981A5051504482 @default.
• W3016565981 hasAuthorship W3016565981A5063985624 @default.
• W3016565981 hasAuthorship W3016565981A5080705880 @default.

• next