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- W3016656289 abstract "Apelinerjik sistem APJ (apelin reseptörü), apelin ve elabeladan oluşmaktadır. APJ, G protein kenetli bir reseptördür. Apelin ve elabela APJ’nin endojen ligandlarıdır. APJ, apelin ve elabela kardiyovasküler dokularda yaygın olarak eksprese edilmektedir. Vazodilatatör, kardiyoprotektif ve anjiyogenik etkilere aracılık eden apelin ve elabelanın pozitif inotropik etkisi oldukça güçlüdür. Apelinin pozitif inotropik etkisinde fosfolipaz C aktivasyonu sonrası kalsiyum bağımlı ve kalsiyum bağımsız mekanizmaların rol oynadığı ileri sürülmektedir. Elabelanın ise mitojenle aktiflenen protein kinaz 1/2-ekstraselüler sinyalle düzenlenen kinaz 1/2 yolağını aktive ederek pozitif inotropik etki gösterdiği düşünülmektedir. Apelin, elabela, bunların analogları ve APJ agonistleri güçlü pozitif inotropik etkileri nedeni ile kalp yetmezliği tedavisinde önemli bir tedavi alternatifi oluşturabilir. Bu derlemede apelinerjik sistemin miyokard fonksiyonuna etkileri ve etki mekanizmaları üzerinde durulmaktadır." @default.
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- W3016656289 date "2020-04-01" @default.
- W3016656289 modified "2023-09-25" @default.
- W3016656289 title "Apelinerjik Sistem ve Miyokardiyal Kontraktilite" @default.
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- W3016656289 doi "https://doi.org/10.32708/uutfd.697633" @default.
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