FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016658140> ?p ?o ?g. }

• W3016658140 endingPage "113976" @default.
• W3016658140 startingPage "113976" @default.
• W3016658140 abstract "The progesterone receptor (PR) mediates progesterone regulation of female reproductive physiology, as well as gene transcription in non-reproductive tissues, such as brain, bone, lung and vasculature, in both women and men. An unusual property of progesterone is its high affinity for the mineralocorticoid receptor (MR), which regulates electrolyte transport in the kidney in humans and other terrestrial vertebrates. In humans, rats, alligators and frogs, progesterone antagonizes activation of the MR by aldosterone, the physiological mineralocorticoid in terrestrial vertebrates. In contrast, in elephant shark, ray-finned fishes and chickens, progesterone activates the MR. Interestingly, cartilaginous fishes and ray-finned fishes do not synthesize aldosterone, raising the question of which steroid(s) activate the MR in cartilaginous fishes and ray-finned fishes. The simpler synthesis of progesterone, compared to cortisol and other corticosteroids, makes progesterone a candidate physiological activator of the MR in elephant sharks and ray-finned fishes. Elephant shark and ray-finned fish MRs are expressed in diverse tissues, including heart, brain and lung, as well as, ovary and testis, two reproductive tissues that are targets for progesterone, which together suggests a multi-faceted physiological role for progesterone activation of the MR in elephant shark and ray-finned fish. The functional consequences of progesterone as an antagonist of some terrestrial vertebrate MRs and as an agonist of fish and chicken MRs are not fully understood. The physiological activities of progesterone through binding to vertebrate MRs merits further investigation." @default.
• W3016658140 created "2020-04-24" @default.
• W3016658140 creator A5066930771 @default.
• W3016658140 creator A5091521664 @default.
• W3016658140 date "2020-07-01" @default.
• W3016658140 modified "2023-09-29" @default.
• W3016658140 title "Progesterone: An enigmatic ligand for the mineralocorticoid receptor" @default.
• W3016658140 cites W1531428660 @default.
• W3016658140 cites W1890227173 @default.
• W3016658140 cites W1894969453 @default.
• W3016658140 cites W1965408181 @default.
• W3016658140 cites W1965783061 @default.
• W3016658140 cites W1974742102 @default.
• W3016658140 cites W1976915351 @default.
• W3016658140 cites W1977518722 @default.
• W3016658140 cites W1977582104 @default.
• W3016658140 cites W1978576530 @default.
• W3016658140 cites W1991531049 @default.
• W3016658140 cites W1992975997 @default.
• W3016658140 cites W1993600102 @default.
• W3016658140 cites W1994398034 @default.
• W3016658140 cites W2014045664 @default.
• W3016658140 cites W2015497140 @default.
• W3016658140 cites W2016866851 @default.
• W3016658140 cites W2017590613 @default.
• W3016658140 cites W2028934754 @default.
• W3016658140 cites W2029930703 @default.
• W3016658140 cites W2030208456 @default.
• W3016658140 cites W2031116735 @default.
• W3016658140 cites W2031512686 @default.
• W3016658140 cites W2031752348 @default.
• W3016658140 cites W2032416959 @default.
• W3016658140 cites W2037612479 @default.
• W3016658140 cites W2045206677 @default.
• W3016658140 cites W2050480410 @default.
• W3016658140 cites W2052160943 @default.
• W3016658140 cites W2052724934 @default.
• W3016658140 cites W2056602728 @default.
• W3016658140 cites W2058070019 @default.
• W3016658140 cites W2059557276 @default.
• W3016658140 cites W2061041720 @default.
• W3016658140 cites W2064008521 @default.
• W3016658140 cites W2064631433 @default.
• W3016658140 cites W2065209840 @default.
• W3016658140 cites W2067481123 @default.
• W3016658140 cites W2068305760 @default.
• W3016658140 cites W2068421311 @default.
• W3016658140 cites W2069417592 @default.
• W3016658140 cites W2076356185 @default.
• W3016658140 cites W2077547488 @default.
• W3016658140 cites W2080637205 @default.
• W3016658140 cites W2082882850 @default.
• W3016658140 cites W2083076927 @default.
• W3016658140 cites W2083193803 @default.
• W3016658140 cites W2085124463 @default.
• W3016658140 cites W2085448623 @default.
• W3016658140 cites W2090015201 @default.
• W3016658140 cites W2090358481 @default.
• W3016658140 cites W2091928432 @default.
• W3016658140 cites W2092950628 @default.
• W3016658140 cites W2099326239 @default.
• W3016658140 cites W2103596394 @default.
• W3016658140 cites W2105609164 @default.
• W3016658140 cites W2111744211 @default.
• W3016658140 cites W2114702154 @default.
• W3016658140 cites W2119638687 @default.
• W3016658140 cites W2120367446 @default.
• W3016658140 cites W2120382923 @default.
• W3016658140 cites W2123653059 @default.
• W3016658140 cites W2124663880 @default.
• W3016658140 cites W2125535253 @default.
• W3016658140 cites W2129970914 @default.
• W3016658140 cites W2132238446 @default.
• W3016658140 cites W2139901604 @default.
• W3016658140 cites W2141757577 @default.
• W3016658140 cites W2152760742 @default.
• W3016658140 cites W2171671716 @default.
• W3016658140 cites W2206859595 @default.
• W3016658140 cites W2227999806 @default.
• W3016658140 cites W2324741442 @default.
• W3016658140 cites W2324848654 @default.
• W3016658140 cites W2557407637 @default.
• W3016658140 cites W2602302035 @default.
• W3016658140 cites W2610903647 @default.
• W3016658140 cites W2617672122 @default.
• W3016658140 cites W2627778393 @default.
• W3016658140 cites W2642459480 @default.
• W3016658140 cites W2692610096 @default.
• W3016658140 cites W2735650555 @default.
• W3016658140 cites W2792189043 @default.
• W3016658140 cites W2794414071 @default.
• W3016658140 cites W2809697208 @default.
• W3016658140 cites W2883078202 @default.
• W3016658140 cites W2888908334 @default.
• W3016658140 cites W2906506916 @default.
• W3016658140 cites W2922463891 @default.
• W3016658140 cites W2938654062 @default.
• W3016658140 cites W2950199888 @default.

• next