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• W3016664593 abstract "Abstract Purpose Knowing the precise flow of cerebrospinal fluid (CSF) is important in the management of multiple neurological diseases. Technology for non-invasively quantifying CSF flow would allow for precise localization of injury and assist in evaluating the viability of certain devices placed in the central nervous system (CNS). Methods We describe a near-infrared fluorescent dye for accurately monitoring CSF flow by positron emission tomography (PET) and fluorescence. IR-783, a commercially available near-infrared dye, was chemically modified and radiolabeled with fluorine-18 to give [ 18 F]-IR783-AMBF 3 . [ 18 F]-IR783-AMBF 3 was intrathecally injected into the rat models with normal and aberrant CSF flow and evaluated by the fluorescence and PET/MRI or PET/CT imaging modes. Results IR783-AMBF 3 was clearly distributed in CSF-containing volumes by PET and fluorescence. We compared IR783-AMBF 3 (fluorescent at 778/793 nm, ex/em) to a shorter-wavelength, fluorescein equivalent (fluorescent at 495/511 nm, ex/em). IR783-AMBF 3 was superior for its ability to image through blood (hemorrhage) and for imaging CSF-flow, through-skin, in subdural-run lumboperitoneal shunts. IR783-AMBF 3 was safe under the tested dosage both in vitro and in vivo . Conclusion The superior imaging properties of IR783-AMBF 3 could lead to enhanced accuracy in the treatment of patients and would assist surgeons in non-invasively diagnosing diseases of the CNS." @default.
• W3016664593 created "2020-04-24" @default.
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• W3016664593 date "2020-04-16" @default.
• W3016664593 modified "2023-10-13" @default.
• W3016664593 title "A near-infrared probe for non-invasively monitoring cerebrospinal fluid flow by 18F-positron emitting tomography and fluorescence" @default.
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• W3016664593 doi "https://doi.org/10.1186/s13550-020-0609-3" @default.
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