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- W3016667346 abstract "Abstract Background Hypothyroidism is a common complex endocrinopathy that typically has an autoimmune etiology, and it affects both humans and dogs. Genetic and environmental factors are both known to play important roles in the disease development. In this study, we sought to identify the genetic risk factors potentially involved in the susceptibility to the disease in the high-risk Giant Schnauzer dog breed. Results By employing genome-wide association followed by fine-mapping (top variant p -value = 5.7 × 10 − 6 ), integrated with whole-genome resequencing and copy number variation analysis, we detected a ~ 8.9 kbp deletion strongly associated ( p -value = 0.0001) with protection against development of hypothyroidism. The deletion is located between two predicted Interferon alpha ( IFNA ) genes and it may eliminate functional elements potentially involved in the transcriptional regulation of these genes. Remarkably, type I IFNs have been extensively associated to human autoimmune hypothyroidism and general autoimmunity. Nonetheless, the extreme genomic complexity of the associated region on CFA11 warrants further long-read sequencing and annotation efforts in order to ascribe functions to the identified deletion and to characterize the canine IFNA gene cluster in more detail. Conclusions Our results expand the current knowledge on genetic determinants of canine hypothyroidism by revealing a significant link with the human counterpart disease, potentially translating into better diagnostic tools across species, and may contribute to improved canine breeding strategies." @default.
- W3016667346 created "2020-04-24" @default.
- W3016667346 creator A5006837188 @default.
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- W3016667346 date "2020-04-16" @default.
- W3016667346 modified "2023-10-14" @default.
- W3016667346 title "Whole-genome genotyping and resequencing reveal the association of a deletion in the complex interferon alpha gene cluster with hypothyroidism in dogs" @default.
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- W3016667346 doi "https://doi.org/10.1186/s12864-020-6700-3" @default.
- W3016667346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7160888" @default.
- W3016667346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32299354" @default.
- W3016667346 hasPublicationYear "2020" @default.
- W3016667346 type Work @default.