FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016682146> ?p ?o ?g. }

• W3016682146 endingPage "096368972090851" @default.
• W3016682146 startingPage "096368972090851" @default.
• W3016682146 abstract "Mesenchymal stem cell (MSC)-based regenerative therapy is regarded as a promising strategy for the treatment of Parkinson’s disease (PD). However, MSC components may exhibit poor intracranial survivability, particularly in the later stages following cell transplantation, limiting their potential curative effect and also clinical applications. Glial cell line-derived neurotrophic factor (GDNF), which encompasses a variety of transforming growth factor beta super family members, has been reported to enhance motor function and exert neuroprotective effects. However, no previous studies have investigated the effects of GDNF on human primary adipose-derived MSCs (hAMSCs), despite its potential for enhancing stem cell survival and promoting therapeutic efficacy in the treatment of PD. In the present study, we proposed a novel approach for enhancing the proliferative capacity and improving the efficacy of hAMSC treatment. Pre-exposure of engineered hAMSCs to GDNF enhanced the proliferation and differentiation of these stem cells in vitro. In addition, in 6-hydroxydopamine-lesioned mice, a common PD model, intracranial injection of hAMSCs-GDNF was associated with greater performance on behavioral tests, larger graft volumes 5 weeks after transplantation, and higher levels of Nestin, glial fibrillary acidic protein, and Tuj-1 differentiation than those treated with hAMSCs-Vector. Following transplantation of hAMSCs-GDNF into the striatum of lesioned models, we observed significant increases in tyrosine hydroxylase- and NeuN-positive staining. These findings highlight the therapeutic potential of hAMSCs-GDNF for patients with PD, as well as an efficient method for promoting therapeutic efficacy of these delivery vehicles." @default.
• W3016682146 created "2020-04-24" @default.
• W3016682146 creator A5013857966 @default.
• W3016682146 creator A5035531071 @default.
• W3016682146 creator A5044405131 @default.
• W3016682146 creator A5044434277 @default.
• W3016682146 creator A5046486161 @default.
• W3016682146 creator A5053985637 @default.
• W3016682146 creator A5055720455 @default.
• W3016682146 creator A5058670321 @default.
• W3016682146 creator A5073953730 @default.
• W3016682146 creator A5088973373 @default.
• W3016682146 date "2020-01-01" @default.
• W3016682146 modified "2023-10-16" @default.
• W3016682146 title "GDNF Promotes Survival and Therapeutic Efficacy of Human Adipose-Derived Mesenchymal Stem Cells in a Mouse Model of Parkinson’s Disease" @default.
• W3016682146 cites W1533317424 @default.
• W3016682146 cites W1840177221 @default.
• W3016682146 cites W1889981011 @default.
• W3016682146 cites W1942711488 @default.
• W3016682146 cites W1950973286 @default.
• W3016682146 cites W1971258758 @default.
• W3016682146 cites W1973722547 @default.
• W3016682146 cites W1989381407 @default.
• W3016682146 cites W1990331450 @default.
• W3016682146 cites W1991208841 @default.
• W3016682146 cites W1996001296 @default.
• W3016682146 cites W2011813261 @default.
• W3016682146 cites W2019125467 @default.
• W3016682146 cites W2030549077 @default.
• W3016682146 cites W2047969391 @default.
• W3016682146 cites W2050784054 @default.
• W3016682146 cites W2054810445 @default.
• W3016682146 cites W2071360006 @default.
• W3016682146 cites W2090673961 @default.
• W3016682146 cites W2103899142 @default.
• W3016682146 cites W2108724455 @default.
• W3016682146 cites W2118428015 @default.
• W3016682146 cites W2121153051 @default.
• W3016682146 cites W2142746129 @default.
• W3016682146 cites W2143171753 @default.
• W3016682146 cites W2145826883 @default.
• W3016682146 cites W2145954079 @default.
• W3016682146 cites W2156202012 @default.
• W3016682146 cites W2159417266 @default.
• W3016682146 cites W2164579436 @default.
• W3016682146 cites W2170493251 @default.
• W3016682146 cites W2315830783 @default.
• W3016682146 cites W2395631443 @default.
• W3016682146 cites W2473929048 @default.
• W3016682146 cites W2507453792 @default.
• W3016682146 cites W2585272077 @default.
• W3016682146 cites W2784259888 @default.
• W3016682146 cites W2784303450 @default.
• W3016682146 cites W2791643624 @default.
• W3016682146 cites W2799816031 @default.
• W3016682146 cites W2807600346 @default.
• W3016682146 cites W2811495931 @default.
• W3016682146 cites W2884938089 @default.
• W3016682146 cites W2916149712 @default.
• W3016682146 cites W2917018165 @default.
• W3016682146 cites W2942128717 @default.
• W3016682146 cites W4211123396 @default.
• W3016682146 cites W4232554989 @default.
• W3016682146 doi "https://doi.org/10.1177/0963689720908512" @default.
• W3016682146 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7444207" @default.
• W3016682146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32292068" @default.
• W3016682146 hasPublicationYear "2020" @default.
• W3016682146 type Work @default.
• W3016682146 sameAs 3016682146 @default.
• W3016682146 citedByCount "16" @default.
• W3016682146 countsByYear W30166821462020 @default.
• W3016682146 countsByYear W30166821462021 @default.
• W3016682146 countsByYear W30166821462022 @default.
• W3016682146 countsByYear W30166821462023 @default.
• W3016682146 crossrefType "journal-article" @default.
• W3016682146 hasAuthorship W3016682146A5013857966 @default.
• W3016682146 hasAuthorship W3016682146A5035531071 @default.
• W3016682146 hasAuthorship W3016682146A5044405131 @default.
• W3016682146 hasAuthorship W3016682146A5044434277 @default.
• W3016682146 hasAuthorship W3016682146A5046486161 @default.
• W3016682146 hasAuthorship W3016682146A5053985637 @default.
• W3016682146 hasAuthorship W3016682146A5055720455 @default.
• W3016682146 hasAuthorship W3016682146A5058670321 @default.
• W3016682146 hasAuthorship W3016682146A5073953730 @default.
• W3016682146 hasAuthorship W3016682146A5088973373 @default.
• W3016682146 hasBestOaLocation W30166821461 @default.
• W3016682146 hasConcept C10882517 @default.
• W3016682146 hasConcept C126322002 @default.
• W3016682146 hasConcept C142724271 @default.
• W3016682146 hasConcept C160539049 @default.
• W3016682146 hasConcept C169760540 @default.
• W3016682146 hasConcept C170493617 @default.
• W3016682146 hasConcept C185856081 @default.
• W3016682146 hasConcept C198826908 @default.
• W3016682146 hasConcept C203014093 @default.
• W3016682146 hasConcept C28328180 @default.
• W3016682146 hasConcept C2911091166 @default.
• W3016682146 hasConcept C71924100 @default.

• next