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- W3016693670 abstract "417 Objectives: Protocols for 18-FDG-PET imaging suggest a 30- to 60-min time window between 18F-FDG injection and data acquisition. This recommendation is based on the assumption of a steady 18-FDG uptake after reaching an equilibrium by 30 min post injection (p.i.). In this study we analysed the dynamics of regional 18-FDG uptake at 30 to 90 min p.i.Methods and Results: Eighty four healthy middle-aged subjects were examined. First, we contrasted summed images for the time frames 30-60 vs. 60-90 min p.i. Following a global mean normalization, a significantly lower relative FDG uptake (figure 1; red clusters, p<0.001 FWE corrected) was found in the cerebellum, parts of the primary visual cortex and pons in the former time frame. A significantly higher relative FDG uptake (figure 1; blue clusters, p<0.001 FWE corrected) was found within extensive parts of the frontal, parietal, and lateral temporal cortex, as well as in the striatum. In the next step, the raw data were reconstructed as 12 five min frames, followed by regions of interest analysis. Herewith, the above results were replicated and extended. Specifically, we found a statistically significant, nearly linear increase/decrease in FDG uptake over the whole acquisition period. Figure 2 shows temporal dynamics for two representative regions, the cerebellum (green line) and inferior frontal gyrus (red line). Conclusions: The relation in FDG uptake between different brain regions changes over the apperent steady state. These results agree with the recently found anti-correlated metabolic cortico-cerebellar resting state networks and may reflect differences in physiological tissue properties (e.g. neuron to glia ratio). Caution should be taken when comparing FDG-PET images acquired at distinct time frames, e.g. within multicenter projects." @default.
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- W3016693670 date "2019-05-01" @default.
- W3016693670 modified "2023-09-27" @default.
- W3016693670 title "Significant changes of regional cerebral FDG uptake during a steady state" @default.
- W3016693670 hasPublicationYear "2019" @default.
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