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- W3016702666 endingPage "451" @default.
- W3016702666 startingPage "440" @default.
- W3016702666 abstract "New tools allow in vivo measurements of ROS in tumors. Mouse modeling and genetic screening approaches have revealed novel complexities and redundancies in endogenous antioxidant systems. Exogenous antioxidants may promote cancer through complex mechanisms. Aberrant NRF2 activation has diverse, and sometimes contradictory, impacts on tumor growth and metastasis. Tissue of origin, tumor stage, and the microenvironment greatly influence the influence of ROS on cancer. Reactive oxygen species (ROS) play important roles in tissue homeostasis, cellular signaling, differentiation, and survival. In this review, we discuss the types of ROS, their impact on cellular processes, and their pro- and antitumorigenic effects. Further, we discuss recent advances in our understanding of both endogenous and exogenous antioxidants in tumorigenic processes. Finally, we discuss how aberrant activation of antioxidant programs by the transcription factor NFE2-related factor 2 (NRF2) influences tumorigenesis and metastasis, and where the current gaps in our knowledge remain. Reactive oxygen species (ROS) play important roles in tissue homeostasis, cellular signaling, differentiation, and survival. In this review, we discuss the types of ROS, their impact on cellular processes, and their pro- and antitumorigenic effects. Further, we discuss recent advances in our understanding of both endogenous and exogenous antioxidants in tumorigenic processes. Finally, we discuss how aberrant activation of antioxidant programs by the transcription factor NFE2-related factor 2 (NRF2) influences tumorigenesis and metastasis, and where the current gaps in our knowledge remain." @default.
- W3016702666 created "2020-04-24" @default.
- W3016702666 creator A5070722987 @default.
- W3016702666 creator A5076253640 @default.
- W3016702666 date "2020-06-01" @default.
- W3016702666 modified "2023-10-14" @default.
- W3016702666 title "The Complex Interplay between Antioxidants and ROS in Cancer" @default.
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