Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016717170> ?p ?o ?g. }
- W3016717170 endingPage "2767" @default.
- W3016717170 startingPage "2767" @default.
- W3016717170 abstract "Inhibitors of the nuclear DNA damage sensor and signalling enzyme poly(ADP-ribose) polymerase (PARP) have recently been introduced in the therapy of cancers deficient in double-strand DNA break repair systems, and ongoing clinical trials aim to extend their use from other forms of cancer non-responsive to conventional treatments. Additionally, PARP inhibitors were suggested to be repurposed for oxidative stress-associated non-oncological diseases resulting in a devastating outcome, or requiring acute treatment. Their well-documented mitochondria- and cytoprotective effects form the basis of PARP inhibitors’ therapeutic use for non-oncological diseases, yet can limit their efficacy in the treatment of cancers. A better understanding of the processes involved in their protective effects may improve the PARP inhibitors’ therapeutic potential in the non-oncological indications. To this end, we endeavoured to summarise the basic features regarding mitochondrial structure and function, review the major PARP activation-induced cellular processes leading to mitochondrial damage, and discuss the role of PARP inhibition-mediated mitochondrial protection in several oxidative stress-associated diseases." @default.
- W3016717170 created "2020-04-24" @default.
- W3016717170 creator A5023908862 @default.
- W3016717170 creator A5082572651 @default.
- W3016717170 date "2020-04-16" @default.
- W3016717170 modified "2023-09-26" @default.
- W3016717170 title "Mitochondrial Protection by PARP Inhibition" @default.
- W3016717170 cites W1528220495 @default.
- W3016717170 cites W1530529896 @default.
- W3016717170 cites W1533853049 @default.
- W3016717170 cites W1542816909 @default.
- W3016717170 cites W1555531912 @default.
- W3016717170 cites W1585781020 @default.
- W3016717170 cites W1589421810 @default.
- W3016717170 cites W1599703185 @default.
- W3016717170 cites W1849928642 @default.
- W3016717170 cites W1934949992 @default.
- W3016717170 cites W1964126982 @default.
- W3016717170 cites W1964617786 @default.
- W3016717170 cites W1965270044 @default.
- W3016717170 cites W1971608015 @default.
- W3016717170 cites W1975087901 @default.
- W3016717170 cites W1975346450 @default.
- W3016717170 cites W1978112502 @default.
- W3016717170 cites W1978256334 @default.
- W3016717170 cites W1982734478 @default.
- W3016717170 cites W1983324471 @default.
- W3016717170 cites W1985423269 @default.
- W3016717170 cites W1985730861 @default.
- W3016717170 cites W1985977889 @default.
- W3016717170 cites W1986720672 @default.
- W3016717170 cites W1991221096 @default.
- W3016717170 cites W1992468844 @default.
- W3016717170 cites W1995074959 @default.
- W3016717170 cites W1995860431 @default.
- W3016717170 cites W1999131612 @default.
- W3016717170 cites W1999682415 @default.
- W3016717170 cites W2006068238 @default.
- W3016717170 cites W2006806309 @default.
- W3016717170 cites W2006920570 @default.
- W3016717170 cites W2007289467 @default.
- W3016717170 cites W2008235034 @default.
- W3016717170 cites W2009321462 @default.
- W3016717170 cites W2009556085 @default.
- W3016717170 cites W2010572143 @default.
- W3016717170 cites W2010651460 @default.
- W3016717170 cites W2011779329 @default.
- W3016717170 cites W2011785467 @default.
- W3016717170 cites W2013642338 @default.
- W3016717170 cites W2014108841 @default.
- W3016717170 cites W2015472023 @default.
- W3016717170 cites W2015720223 @default.
- W3016717170 cites W2015798899 @default.
- W3016717170 cites W2017094200 @default.
- W3016717170 cites W2018776448 @default.
- W3016717170 cites W2020074045 @default.
- W3016717170 cites W2024306318 @default.
- W3016717170 cites W2026867422 @default.
- W3016717170 cites W2034058449 @default.
- W3016717170 cites W2035686223 @default.
- W3016717170 cites W2036132575 @default.
- W3016717170 cites W2037195306 @default.
- W3016717170 cites W2037283794 @default.
- W3016717170 cites W2037820827 @default.
- W3016717170 cites W2039276913 @default.
- W3016717170 cites W2040605467 @default.
- W3016717170 cites W2041780477 @default.
- W3016717170 cites W2042572548 @default.
- W3016717170 cites W2043196855 @default.
- W3016717170 cites W2043395027 @default.
- W3016717170 cites W2046843522 @default.
- W3016717170 cites W2047298360 @default.
- W3016717170 cites W2051439699 @default.
- W3016717170 cites W2053265248 @default.
- W3016717170 cites W2055063491 @default.
- W3016717170 cites W2055097137 @default.
- W3016717170 cites W2056908150 @default.
- W3016717170 cites W2058340977 @default.
- W3016717170 cites W2060811345 @default.
- W3016717170 cites W2062440161 @default.
- W3016717170 cites W2063303997 @default.
- W3016717170 cites W2063317376 @default.
- W3016717170 cites W2065721484 @default.
- W3016717170 cites W2065916701 @default.
- W3016717170 cites W2067138633 @default.
- W3016717170 cites W2068048197 @default.
- W3016717170 cites W2068766234 @default.
- W3016717170 cites W2070851102 @default.
- W3016717170 cites W2073095545 @default.
- W3016717170 cites W2074161856 @default.
- W3016717170 cites W2075491707 @default.
- W3016717170 cites W2077996001 @default.
- W3016717170 cites W2078710083 @default.
- W3016717170 cites W2082231023 @default.
- W3016717170 cites W2084060660 @default.
- W3016717170 cites W2087282685 @default.
- W3016717170 cites W2088629175 @default.
- W3016717170 cites W2089393514 @default.