Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016718477> ?p ?o ?g. }
- W3016718477 endingPage "545" @default.
- W3016718477 startingPage "529" @default.
- W3016718477 abstract "Abstract Advances in the understanding and management of bipolar disorder (BD) have been slow to emerge. Despite notable recent developments in neurosciences, our conceptualization of the nature of this mental disorder has not meaningfully progressed. One of the key reasons for this scenario is the continuing lack of a comprehensive disease model. Within the increasing complexity of modern research methods, there is a clear need for an overarching theoretical framework, in which findings are assimilated and predictions are generated. In this review and hypothesis article, we propose such a framework, one in which dysregulated energy expenditure is a primary, sufficient cause for BD. Our proposed model is centered on the disruption of the molecular and cellular network regulating energy production and expenditure, as well its potential secondary adaptations and compensatory mechanisms. We also focus on the putative longitudinal progression of this pathological process, considering its most likely periods for onset, such as critical periods that challenges energy homeostasis (e.g. neurodevelopment, social isolation), and the resulting short and long-term phenotypical manifestations." @default.
- W3016718477 created "2020-04-24" @default.
- W3016718477 creator A5032613018 @default.
- W3016718477 creator A5068850044 @default.
- W3016718477 creator A5076331964 @default.
- W3016718477 creator A5083198014 @default.
- W3016718477 date "2020-06-01" @default.
- W3016718477 modified "2023-10-02" @default.
- W3016718477 title "What is bipolar disorder? A disease model of dysregulated energy expenditure" @default.
- W3016718477 cites W107422749 @default.
- W3016718477 cites W1500139954 @default.
- W3016718477 cites W1502606149 @default.
- W3016718477 cites W1529625339 @default.
- W3016718477 cites W1547936433 @default.
- W3016718477 cites W1572993633 @default.
- W3016718477 cites W1734757931 @default.
- W3016718477 cites W1794396397 @default.
- W3016718477 cites W1833306283 @default.
- W3016718477 cites W1854033343 @default.
- W3016718477 cites W1878277356 @default.
- W3016718477 cites W1925937396 @default.
- W3016718477 cites W1934704113 @default.
- W3016718477 cites W1956327946 @default.
- W3016718477 cites W1966279131 @default.
- W3016718477 cites W1967182648 @default.
- W3016718477 cites W1970597681 @default.
- W3016718477 cites W1971797700 @default.
- W3016718477 cites W1973986591 @default.
- W3016718477 cites W1974323299 @default.
- W3016718477 cites W1974756058 @default.
- W3016718477 cites W1975398216 @default.
- W3016718477 cites W1975441602 @default.
- W3016718477 cites W1975487548 @default.
- W3016718477 cites W1977653683 @default.
- W3016718477 cites W1978453350 @default.
- W3016718477 cites W1978881364 @default.
- W3016718477 cites W1982912347 @default.
- W3016718477 cites W1983372194 @default.
- W3016718477 cites W1983485726 @default.
- W3016718477 cites W1984236915 @default.
- W3016718477 cites W1984616729 @default.
- W3016718477 cites W1985646163 @default.
- W3016718477 cites W1986031990 @default.
- W3016718477 cites W1986484841 @default.
- W3016718477 cites W1987908992 @default.
- W3016718477 cites W1987953899 @default.
- W3016718477 cites W1988375440 @default.
- W3016718477 cites W1989355184 @default.
- W3016718477 cites W1989598267 @default.
- W3016718477 cites W1990574575 @default.
- W3016718477 cites W1991530152 @default.
- W3016718477 cites W1993350139 @default.
- W3016718477 cites W1996449347 @default.
- W3016718477 cites W1997089027 @default.
- W3016718477 cites W1999491748 @default.
- W3016718477 cites W2001260913 @default.
- W3016718477 cites W2003778535 @default.
- W3016718477 cites W2006810478 @default.
- W3016718477 cites W2008041167 @default.
- W3016718477 cites W2008443876 @default.
- W3016718477 cites W2010348734 @default.
- W3016718477 cites W2010498925 @default.
- W3016718477 cites W2010842586 @default.
- W3016718477 cites W2011578117 @default.
- W3016718477 cites W2012002548 @default.
- W3016718477 cites W2012559638 @default.
- W3016718477 cites W2013872437 @default.
- W3016718477 cites W2014602095 @default.
- W3016718477 cites W2016795978 @default.
- W3016718477 cites W2018445411 @default.
- W3016718477 cites W2018710502 @default.
- W3016718477 cites W2021486009 @default.
- W3016718477 cites W2021597195 @default.
- W3016718477 cites W2022333848 @default.
- W3016718477 cites W2022429540 @default.
- W3016718477 cites W2023079854 @default.
- W3016718477 cites W2025050665 @default.
- W3016718477 cites W2025090702 @default.
- W3016718477 cites W2025810387 @default.
- W3016718477 cites W2026555101 @default.
- W3016718477 cites W2029036505 @default.
- W3016718477 cites W2029835226 @default.
- W3016718477 cites W2030111883 @default.
- W3016718477 cites W2030492864 @default.
- W3016718477 cites W2031703986 @default.
- W3016718477 cites W2032979746 @default.
- W3016718477 cites W2033068739 @default.
- W3016718477 cites W2035633002 @default.
- W3016718477 cites W2037663136 @default.
- W3016718477 cites W2037703570 @default.
- W3016718477 cites W2039038315 @default.
- W3016718477 cites W2040181124 @default.
- W3016718477 cites W2041069795 @default.
- W3016718477 cites W2042040508 @default.
- W3016718477 cites W2042422091 @default.
- W3016718477 cites W2042790956 @default.
- W3016718477 cites W2043167111 @default.
- W3016718477 cites W2045590924 @default.