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- W3016720267 endingPage "2170" @default.
- W3016720267 startingPage "2156" @default.
- W3016720267 abstract "Macrophages have a leading position in the tumor microenvironment (TME) which paves the way to carcinogenesis. Initially, monocytes and macrophages are recruited to the sites where the tumor develops. Under the guidance of different microenvironmental signals, macrophages would polarize into two functional phenotypes, named as classically activated macrophages (M1) and alternatively activated macrophages (M2). Contrary to the anti-tumor effect of M1, M2 exerts anti-inflammatory and tumorigenic characters. In progressive tumor, M2 tumor-associated macrophages (TAMs) are in the majority, being vital regulators reacting upon TME. This review elaborates on the role of TAMs in tumor progression. Furthermore, prospective macrophage-focused therapeutic strategies, including drugs not only in clinical trials but also at primary research stages, are summarized followed by a discussion about their clinical application values. Nanoparticulate systems with efficient drug delivery and improved antitumor effect are also summed up in this article." @default.
- W3016720267 created "2020-04-24" @default.
- W3016720267 creator A5003277579 @default.
- W3016720267 creator A5053340431 @default.
- W3016720267 creator A5056353018 @default.
- W3016720267 creator A5058077218 @default.
- W3016720267 creator A5059829197 @default.
- W3016720267 creator A5070384936 @default.
- W3016720267 date "2020-11-01" @default.
- W3016720267 modified "2023-10-18" @default.
- W3016720267 title "The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy" @default.
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