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• W3016732475 abstract "Fungi cause life-threatening infections and pose a serious threat to human health as there are very few effective antifungal drugs. Candida albicans is a major human fungal pathogen and cause of morbidity and mortality in immunocompromised individuals. A key trait that enables C. albicans virulence is its ability to transition between yeast and filamentous forms. Understanding the mechanisms regulating this virulence trait can facilitate the development of much-needed, novel therapeutic strategies. A key regulator of morphogenesis is the molecular chaperone Hsp90, which is crucial for proteostasis. Here, we expanded our understanding of how proteostasis regulates fungal morphogenesis and identified the proteasome as a repressor of filamentation in C. albicans and related species. Our work suggests that proteasome inhibition overwhelms Hsp90 function, thereby inducing morphogenesis. This work provides a foundation for understanding the role of the proteasome in fungal virulence and offers potential for targeting the proteasome to disarm fungal pathogens." @default.
• W3016732475 created "2020-04-24" @default.
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• W3016732475 date "2020-04-28" @default.
• W3016732475 modified "2023-09-24" @default.
• W3016732475 title "The Proteasome Governs Fungal Morphogenesis via Functional Connections with Hsp90 and cAMP-Protein Kinase A Signaling" @default.
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• W3016732475 doi "https://doi.org/10.1128/mbio.00290-20" @default.
• W3016732475 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7175089" @default.
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