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- W3016735575 abstract "Corynebacteriales cells are surrounded by a multilayered cell envelope with unique architecture and composition. Corynebacterium glutamicum has become an increasingly used model to understand both biosynthesis and assembly of this complex compartment of the cell. The specific core of this envelope consists of a huge mycoloyl-arabinogalactan-peptidoglycan (mAGP) complex that constitutes the building support for an outer hydrophobic barrier mainly composed of mycolates containing glycolipids. Besides this basic specific core, the envelope contains other polymers such as lipomannan (LM) and lipoarabinomannan (LAM) but their localization and their functional role is still elusive. Finally, the more external layers encompass some strains of C. glutamicum: the outer layer and the S-layer which may have important roles in specific environments. The biosynthetic pathways involved in the synthesis of peptidoglycan, arabinogalactan and mycolates have been quite well characterized and are exhaustively described. In the frame of this review, we focused exclusively on what has been clearly demonstrated in Corynebaterium glutamicum and, when relevant, we compare to what is known in Mycobacterium species. The precise assembly of the whole envelope as a function of time and space is still to be discovered and represent an exciting challenge for the next decade." @default.
- W3016735575 created "2020-04-24" @default.
- W3016735575 creator A5004704781 @default.
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- W3016735575 creator A5050382321 @default.
- W3016735575 creator A5091625792 @default.
- W3016735575 date "2020-01-01" @default.
- W3016735575 modified "2023-10-01" @default.
- W3016735575 title "Architecture and Biogenesis of the Cell Envelope of Corynebacterium glutamicum" @default.
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