Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016804958> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W3016804958 endingPage "1" @default.
- W3016804958 startingPage "1" @default.
- W3016804958 abstract "The pleiotropic cytokine transforming growth factor-beta 1 (TGFβ1) has been shown to play pivotal roles in a variety of different cell types including immune cells such as T cells, monocytes/macrophages as well as microglia. As the resident immune cell population of the central nervous system (CNS), microglia are essential effector cells during physiological and pathological events. Microglia originate from mesodermal progenitors that arise from the yolk sac and colonize the embryonic CNS where they adopt a mature microglia-specific phenotypic pattern including expression of P2ry12, Tmem119, Olfml3, Siglech, Gpr34, Hexb, and Fcrls. The differentiation and maturation of postnatal microglia, as well as the regulation of the complex functional repertoire of mature microglia, needs to be carefully orchestrated. Here, we demonstrate that the deletion of Tgfbr2 in early postnatal microglia results in a loss of microglia maturation whereas silencing of TGFβ signaling in adult microglia does neither result in impairment of the microglia-specific gene expression signatures, nor is microglial survival and maintenance affected. Tgfbr2-deficient microglia were characterized by distinct morphological changes and transcriptome analysis using RNAseq revealed that loss of TGFβ signaling results in the upregulation of microglia activation and priming markers. Taken together, recent studies employing sophisticated transgenic approaches to silence microglial TGFβ signaling have revealed that TGFβ1 is indispensable for microglia maturation and the establishment of the microglia-specific gene expression pattern as well as the homeostasis of adult microglia and the control of excessive microglia activation." @default.
- W3016804958 created "2020-04-24" @default.
- W3016804958 creator A5004683075 @default.
- W3016804958 date "2020-04-01" @default.
- W3016804958 modified "2023-09-25" @default.
- W3016804958 title "Tgfb1‐mediated Regulation of Microglia Maturation and Activation" @default.
- W3016804958 doi "https://doi.org/10.1096/fasebj.2020.34.s1.00380" @default.
- W3016804958 hasPublicationYear "2020" @default.
- W3016804958 type Work @default.
- W3016804958 sameAs 3016804958 @default.
- W3016804958 citedByCount "0" @default.
- W3016804958 crossrefType "journal-article" @default.
- W3016804958 hasAuthorship W3016804958A5004683075 @default.
- W3016804958 hasBestOaLocation W30168049581 @default.
- W3016804958 hasConcept C104317684 @default.
- W3016804958 hasConcept C145103041 @default.
- W3016804958 hasConcept C169760540 @default.
- W3016804958 hasConcept C203014093 @default.
- W3016804958 hasConcept C2776914184 @default.
- W3016804958 hasConcept C2779830541 @default.
- W3016804958 hasConcept C2908647359 @default.
- W3016804958 hasConcept C54355233 @default.
- W3016804958 hasConcept C71924100 @default.
- W3016804958 hasConcept C86803240 @default.
- W3016804958 hasConcept C87753298 @default.
- W3016804958 hasConcept C95444343 @default.
- W3016804958 hasConcept C99454951 @default.
- W3016804958 hasConceptScore W3016804958C104317684 @default.
- W3016804958 hasConceptScore W3016804958C145103041 @default.
- W3016804958 hasConceptScore W3016804958C169760540 @default.
- W3016804958 hasConceptScore W3016804958C203014093 @default.
- W3016804958 hasConceptScore W3016804958C2776914184 @default.
- W3016804958 hasConceptScore W3016804958C2779830541 @default.
- W3016804958 hasConceptScore W3016804958C2908647359 @default.
- W3016804958 hasConceptScore W3016804958C54355233 @default.
- W3016804958 hasConceptScore W3016804958C71924100 @default.
- W3016804958 hasConceptScore W3016804958C86803240 @default.
- W3016804958 hasConceptScore W3016804958C87753298 @default.
- W3016804958 hasConceptScore W3016804958C95444343 @default.
- W3016804958 hasConceptScore W3016804958C99454951 @default.
- W3016804958 hasIssue "S1" @default.
- W3016804958 hasLocation W30168049581 @default.
- W3016804958 hasOpenAccess W3016804958 @default.
- W3016804958 hasPrimaryLocation W30168049581 @default.
- W3016804958 hasRelatedWork W2092427927 @default.
- W3016804958 hasRelatedWork W2286958858 @default.
- W3016804958 hasRelatedWork W2401782172 @default.
- W3016804958 hasRelatedWork W2460405435 @default.
- W3016804958 hasRelatedWork W2734804530 @default.
- W3016804958 hasRelatedWork W2809913775 @default.
- W3016804958 hasRelatedWork W2890627020 @default.
- W3016804958 hasRelatedWork W2913737174 @default.
- W3016804958 hasRelatedWork W3107895302 @default.
- W3016804958 hasRelatedWork W4309467168 @default.
- W3016804958 hasVolume "34" @default.
- W3016804958 isParatext "false" @default.
- W3016804958 isRetracted "false" @default.
- W3016804958 magId "3016804958" @default.
- W3016804958 workType "article" @default.