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• W3016848030 abstract "Objectives: To investigate whether the fecal microbiome of Parkinson's disease patients differs from that of healthy population and explore the pathogenesis and new treatment of idiopathic Parkinson's disease. Methods: A total of 30 patients diagnosed as idiopathic Parkinson disease (PD group) in Beijing Friendship Hospital between April 2017 and June 2018 were enrolled and 30 healthy controls (NC group) were recruited at the same time.Medical records and score of unified Parkinson's disease rating scale (UPDRS) were collected and fresh fecal samples were obtained and stored in refrigerator (-80℃). The microbial compositions of fecal samples were investigated by 16S rRNA gene sequencing targeting the V3-V4 region. The taxa abundance and microbial composition were tested. Results: There was no difference of age and sex in PD and NC groups. Chao1 and Shannon indexes tended to be higher in PD group, yet failed to reach statistic significance (P=0.115 and 0.052). Relative abundance of gut microbiota differed in each taxonomic category. The relative abundance of Firmicutes in PD group was 53.6%(41.7%-64.8%), while that of Bacteroidetes in NC group was 51.7%(31.7%-65.3%). The ratios of Firmicutes to Bacteroidetes were significantly different between the two groups (1.6(0.9-3.4) vs 0.7(0.5-1.4), P=0.001). In Clostridia, Bacilli and Erysipelotrichia of Firmicutes, the relative abundances of Clostridiales, Christensenellaceae, Peptoclostridium, Lactobacillus and Erysipelatoclostridium were higher in PD group (P=0.024, 0.046, 0.036, 0.022 and 0.037). The relative abundance of Prevotella of Bacteroidales, was lower in PD group, yet failed to reach statistic significance (P=0.121). The relative abundances of Alistipes of Rikenellaceae and Butyricimonas of Marinilabiliales in PD group were significantly higher than those in NC group (P=0.047 and 0.033). The relative abundance of Bifidobacterium of Actinobacteria was significanly higher in PD group when compared with NC group (P=0.009). Despite the relatively low abundance, Akkermansia of Verrucomicrobia was significantly higher in PD group than in NC group (P=0.025). Conclusion: The structures of the fecal microbiota differ significantly between PD patients and healthy controls.目的： 研究原发性帕金森病（PD）患者肠道菌群丰度与正常人群之间的变化，为探索原发性PD的发病机制及治疗寻找新思路。 方法： 选取2017年4月至2018年6月于北京友谊医院神经内科就诊，诊断为原发性PD的患者30例（原发性PD组）；同期健康志愿者30名为健康对照组（NC）。收集原发性PD组患者病史资料、统一PD评定量表（UPDRS），采集两组受试者的新鲜粪便，于-80℃冰箱冻存。对粪便菌群的16S rRNA基因V3-V4区进行测序，比较两组的菌群多样性和各物种分类水平上的菌群差异。 结果： 原发性PD组和NC组年龄、性别无明显差异，原发性PD组的chao1指数、Shannon指数高于NC组，但差异无统计学意义（P=0.115、0.052）。两组肠道菌群组成在各物种分类水平上均存在明显差异。原发性PD组厚壁菌门占53.6%(41.7%~64.8%)，而NC组拟杆菌占51.7%(31.7%~65.3%)。两组的厚壁菌门与拟杆菌门的比值差异有统计学意义[1.6(0.9~3.4）比0.7(0.5~1.4)，P=0.001]。在厚壁菌门所属的梭菌纲、杆菌纲、丹毒丝菌纲中，梭菌目、Christensenellace、Peptoclostridium、乳杆菌属以及Erysipelatoclostridium的菌群相对丰度在原发性PD组高于NC组（P=0.024、0.046、0.036、0.022、0.037）。原发性PD组在拟杆菌目内普雷沃菌科丰度偏低，但差异无统计学意义（P=0.121）；理研菌科的Alistipes属、Marinilabiliales的丁酸弧菌属较NC组丰度偏高（P=0.047、0.033）。在放线菌门的双歧杆菌属，原发性PD组的相对丰度高于NC组（P=0.009）。尽管相对丰度较低，原发性PD组在疣微菌门及Akkermansia的相对丰度也高于NC组（P=0.025）。 结论： 原发性PD患者肠道微生物物种组成较健康人群发生显著变化。." @default.
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• W3016848030 date "2020-04-07" @default.
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• W3016848030 title "[Features of gut microbiota in patients with idiopathic Parkinson's disease]." @default.
• W3016848030 doi "https://doi.org/10.3760/cma.j.cn112137-20190702-01480" @default.
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