FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016893324> ?p ?o ?g. }

• W3016893324 endingPage "750" @default.
• W3016893324 startingPage "750" @default.
• W3016893324 abstract "The starting point of successful hazard assessment is the generation of unbiased and trustworthy data. Conventional toxicity testing deals with extensive observations of phenotypic endpoints in vivo and complementing in vitro models. The increasing development of novel materials and chemical compounds dictates the need for a better understanding of the molecular changes occurring in exposed biological systems. Transcriptomics enables the exploration of organisms’ responses to environmental, chemical, and physical agents by observing the molecular alterations in more detail. Toxicogenomics integrates classical toxicology with omics assays, thus allowing the characterization of the mechanism of action (MOA) of chemical compounds, novel small molecules, and engineered nanomaterials (ENMs). Lack of standardization in data generation and analysis currently hampers the full exploitation of toxicogenomics-based evidence in risk assessment. To fill this gap, TGx methods need to take into account appropriate experimental design and possible pitfalls in the transcriptomic analyses as well as data generation and sharing that adhere to the FAIR (Findable, Accessible, Interoperable, and Reusable) principles. In this review, we summarize the recent advancements in the design and analysis of DNA microarray, RNA sequencing (RNA-Seq), and single-cell RNA-Seq (scRNA-Seq) data. We provide guidelines on exposure time, dose and complex endpoint selection, sample quality considerations and sample randomization. Furthermore, we summarize publicly available data resources and highlight applications of TGx data to understand and predict chemical toxicity potential. Additionally, we discuss the efforts to implement TGx into regulatory decision making to promote alternative methods for risk assessment and to support the 3R (reduction, refinement, and replacement) concept. This review is the first part of a three-article series on Transcriptomics in Toxicogenomics. These initial considerations on Experimental Design, Technologies, Publicly Available Data, Regulatory Aspects, are the starting point for further rigorous and reliable data preprocessing and modeling, described in the second and third part of the review series." @default.
• W3016893324 created "2020-04-24" @default.
• W3016893324 creator A5017246181 @default.
• W3016893324 creator A5018763133 @default.
• W3016893324 creator A5025810407 @default.
• W3016893324 creator A5027737864 @default.
• W3016893324 creator A5028682033 @default.
• W3016893324 creator A5029689432 @default.
• W3016893324 creator A5035286212 @default.
• W3016893324 creator A5039991320 @default.
• W3016893324 creator A5041632230 @default.
• W3016893324 creator A5047081771 @default.
• W3016893324 creator A5053054748 @default.
• W3016893324 creator A5054456416 @default.
• W3016893324 creator A5055082959 @default.
• W3016893324 creator A5055943187 @default.
• W3016893324 creator A5057193559 @default.
• W3016893324 creator A5059827878 @default.
• W3016893324 creator A5080433751 @default.
• W3016893324 creator A5084318415 @default.
• W3016893324 creator A5088194977 @default.
• W3016893324 creator A5088226570 @default.
• W3016893324 date "2020-04-15" @default.
• W3016893324 modified "2023-10-14" @default.
• W3016893324 title "Transcriptomics in Toxicogenomics, Part I: Experimental Design, Technologies, Publicly Available Data, and Regulatory Aspects" @default.
• W3016893324 cites W1544923801 @default.
• W3016893324 cites W1696199194 @default.
• W3016893324 cites W1802936766 @default.
• W3016893324 cites W1905645718 @default.
• W3016893324 cites W1908738074 @default.
• W3016893324 cites W1964904043 @default.
• W3016893324 cites W1965536430 @default.
• W3016893324 cites W1968541042 @default.
• W3016893324 cites W1969511428 @default.
• W3016893324 cites W1970156673 @default.
• W3016893324 cites W1973565395 @default.
• W3016893324 cites W1979283544 @default.
• W3016893324 cites W1984276938 @default.
• W3016893324 cites W1986437187 @default.
• W3016893324 cites W1986523067 @default.
• W3016893324 cites W1995420396 @default.
• W3016893324 cites W1999785647 @default.
• W3016893324 cites W2008107550 @default.
• W3016893324 cites W2010637767 @default.
• W3016893324 cites W2014628254 @default.
• W3016893324 cites W2015929094 @default.
• W3016893324 cites W2017066108 @default.
• W3016893324 cites W2020541351 @default.
• W3016893324 cites W2021074697 @default.
• W3016893324 cites W2021102901 @default.
• W3016893324 cites W2021560851 @default.
• W3016893324 cites W2023109450 @default.
• W3016893324 cites W2029980980 @default.
• W3016893324 cites W2030017878 @default.
• W3016893324 cites W2035375392 @default.
• W3016893324 cites W2036508923 @default.
• W3016893324 cites W2039057614 @default.
• W3016893324 cites W2040626959 @default.
• W3016893324 cites W2043548074 @default.
• W3016893324 cites W2045359131 @default.
• W3016893324 cites W2056640720 @default.
• W3016893324 cites W2062987964 @default.
• W3016893324 cites W2068767807 @default.
• W3016893324 cites W2074716823 @default.
• W3016893324 cites W2078344447 @default.
• W3016893324 cites W2081754847 @default.
• W3016893324 cites W2082465893 @default.
• W3016893324 cites W2087575134 @default.
• W3016893324 cites W2094348762 @default.
• W3016893324 cites W2096192437 @default.
• W3016893324 cites W2097917417 @default.
• W3016893324 cites W2098303558 @default.
• W3016893324 cites W2098967508 @default.
• W3016893324 cites W2099536383 @default.
• W3016893324 cites W2099940645 @default.
• W3016893324 cites W2106878780 @default.
• W3016893324 cites W2110768394 @default.
• W3016893324 cites W2114090345 @default.
• W3016893324 cites W2117326659 @default.
• W3016893324 cites W2118258530 @default.
• W3016893324 cites W2119017543 @default.
• W3016893324 cites W2121604817 @default.
• W3016893324 cites W2123454534 @default.
• W3016893324 cites W2124717298 @default.
• W3016893324 cites W2127372456 @default.
• W3016893324 cites W2131005351 @default.
• W3016893324 cites W2135793768 @default.
• W3016893324 cites W2136420678 @default.
• W3016893324 cites W2138003976 @default.
• W3016893324 cites W2138352298 @default.
• W3016893324 cites W2143129697 @default.
• W3016893324 cites W2143364665 @default.
• W3016893324 cites W2147564235 @default.
• W3016893324 cites W2149573463 @default.
• W3016893324 cites W2151260845 @default.
• W3016893324 cites W2151924106 @default.
• W3016893324 cites W2153655918 @default.
• W3016893324 cites W2156631105 @default.

• next