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• W3016906209 endingPage "106466" @default.
• W3016906209 startingPage "106466" @default.
• W3016906209 abstract "Prostaglandins (PG) have primary functions in the reproductive tract, however, the mechanism of regulation of PG secretion in the endometrium is unclear. Estrogen as a predominant regulator of uterine functions during the mammalian estrous cycle and effects of estrogen on synthesis of PG and function in uterine tissues of cattle are not fully understood. In this study, there was evaluation of the concentration- and time-effects of 17β-estradiol on PG synthesis in endometrial explants of cattle, focusing on the secretion of prostaglandin E2 (PGE2) and prostaglandin F2α (PGF2α) as well as relative abundance of mRNA transcript and protein for both the enzymes responsible for PGE2 and PGF2α synthesis, including prostaglandin-endoperoxide synthase 1 and 2 (PTGS1, PTGS2), PGE2 synthase (PGES), PGF2α synthase (PGFS), and carbonyl reductase (CBR1), and the receptors responsible for downstream PGE2 (PTGER2, PTGER4) and PGF2α (PTGFR) signaling. Results indicated that 17β-estradiol increased PGE2 and PGF2α production at concentrations ranging from 10-11 to 10-8 M. Furthermore, abundances of PTGS1, PTGS2, PGES, PGFS, PTGER2, PTGER4, and PTGFR mRNA transcripts and protein were greater immediately after 17β-estradiol treatment at almost all the concentrations, while these CBR1 abundances were less as a result of treatments with 17β-estradiol. These data support the hypothesis that estradiol modulates the synthesis and function of PG in the endometrium of cattle." @default.
• W3016906209 created "2020-04-24" @default.
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• W3016906209 date "2020-05-01" @default.
• W3016906209 modified "2023-10-16" @default.
• W3016906209 title "17β-estradiol regulates prostaglandin E2 and F2α synthesis and function in endometrial explants of cattle" @default.
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• W3016906209 doi "https://doi.org/10.1016/j.anireprosci.2020.106466" @default.
• W3016906209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32414468" @default.
• W3016906209 hasPublicationYear "2020" @default.
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