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- W3016907998 endingPage "442" @default.
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- W3016907998 abstract "Background: Atopic dermatitis is a common inflammatory skin disorder that affects up to 15–20% of the population and is characterized by recurrent eczematous lesions with intense itching. As a heterogeneous disease, multiple factors have been suggested to explain the nature of atopic dermatitis (AD), and its high prevalence makes it necessary to periodically compile and update the new information available. In this systematic review, the focus is set at the genetic and epigenetic studies carried out in the last years. Methods: A systematic literature review was conducted in three scientific publication databases (PubMed, Cochrane Library, and Scopus). The search was restricted to publications indexed from July 2016 to December 2019, and keywords related to atopic dermatitis genetics and epigenetics were used. Results: A total of 73 original papers met the inclusion criteria established, including 9 epigenetic studies. A total of 62 genes and 5 intergenic regions were described as associated with AD. Conclusion: Filaggrin (FLG) polymorphisms are confirmed as key genetic determinants for AD development, but also epigenetic regulation and other genes with functions mainly related to the immune system and extracellular matrix, reinforcing the notion of skin homeostasis breakage in AD." @default.
- W3016907998 created "2020-04-24" @default.
- W3016907998 creator A5002826578 @default.
- W3016907998 creator A5005765631 @default.
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- W3016907998 creator A5053978783 @default.
- W3016907998 creator A5059598885 @default.
- W3016907998 creator A5081026439 @default.
- W3016907998 date "2020-04-18" @default.
- W3016907998 modified "2023-10-18" @default.
- W3016907998 title "Genetics and Epigenetics of Atopic Dermatitis: An Updated Systematic Review" @default.
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