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- W3016926598 endingPage "e3000220" @default.
- W3016926598 startingPage "e3000220" @default.
- W3016926598 abstract "Many lines of evidence point to links between sleep regulation and energy homeostasis, but mechanisms underlying these connections are unknown. During Caenorhabditis elegans sleep, energetic stores are allocated to nonneural tasks with a resultant drop in the overall fat stores and energy charge. Mutants lacking KIN-29, the C. elegans homolog of a mammalian Salt-Inducible Kinase (SIK) that signals sleep pressure, have low ATP levels despite high-fat stores, indicating a defective response to cellular energy deficits. Liberating energy stores corrects adiposity and sleep defects of kin-29 mutants. kin-29 sleep and energy homeostasis roles map to a set of sensory neurons that act upstream of fat regulation as well as of central sleep-controlling neurons, suggesting hierarchical somatic/neural interactions regulating sleep and energy homeostasis. Genetic interaction between kin-29 and the histone deacetylase hda-4 coupled with subcellular localization studies indicate that KIN-29 acts in the nucleus to regulate sleep. We propose that KIN-29/SIK acts in nuclei of sensory neuroendocrine cells to transduce low cellular energy charge into the mobilization of energy stores, which in turn promotes sleep." @default.
- W3016926598 created "2020-04-24" @default.
- W3016926598 creator A5009974587 @default.
- W3016926598 creator A5024282987 @default.
- W3016926598 creator A5042187168 @default.
- W3016926598 creator A5072904463 @default.
- W3016926598 date "2020-04-21" @default.
- W3016926598 modified "2023-10-06" @default.
- W3016926598 title "A salt-induced kinase is required for the metabolic regulation of sleep" @default.
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