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- W3016934274 endingPage "1650" @default.
- W3016934274 startingPage "1635" @default.
- W3016934274 abstract "Abstract Inherited arrhythmias are disorders caused by one or more genetic mutations that increase the risk of arrhythmia, which result in life-long risk of sudden death. These mutations either primarily perturb electrophysiological homeostasis (e.g. long QT syndrome and catecholaminergic polymorphic ventricular tachycardia), cause structural disease that is closely associated with severe arrhythmias (e.g. hypertrophic cardiomyopathy), or cause a high propensity for arrhythmia in combination with altered myocardial structure and function (e.g. arrhythmogenic cardiomyopathy). Currently available therapies offer incomplete protection from arrhythmia and fail to alter disease progression. Recent studies suggest that gene therapies may provide potent, molecularly targeted options for at least a subset of inherited arrhythmias. Here, we provide an overview of gene therapy strategies, and review recent studies on gene therapies for catecholaminergic polymorphic ventricular tachycardia and hypertrophic cardiomyopathy caused by MYBPC3 mutations." @default.
- W3016934274 created "2020-04-24" @default.
- W3016934274 creator A5004439062 @default.
- W3016934274 creator A5032725801 @default.
- W3016934274 creator A5043563400 @default.
- W3016934274 creator A5057815632 @default.
- W3016934274 date "2020-04-22" @default.
- W3016934274 modified "2023-10-13" @default.
- W3016934274 title "Gene therapy for inherited arrhythmias" @default.
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