FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016947102> ?p ?o ?g. }

• W3016947102 endingPage "2711" @default.
• W3016947102 startingPage "2711" @default.
• W3016947102 abstract "Schistosomiasis is an immunopathogenic disease in which a T helper (Th) cell type 2-like response plays vital roles. Hepatic fibrosis is its main pathologic manifestations, which is the leading cause of hepatic cirrhosis. Co-infections of Schistosoma japonicum (Sj) with other pathogens are frequently encountered but are easily ignored in clinical studies, and effective therapeutic interventions are lacking. In this study, we explored the effect of Toxoplasma gondii (Tg) prior infection on Th1/Th2 response, community shifts in gut microbiome (GM), and the pathogenesis of schistosomiasis in murine hosts. Mice were prior infected with Tg before Sj infection. The effects of co-infection on Th1/Th2 response and hepatic fibrosis were analyzed. Furthermore, we investigated this issue by sequencing 16S rRNA from fecal specimens to define the GM profiles during co-infection. Tg prior infection markedly reduced the granuloma size and collagen deposit in livers against Sj infection. Prior infection promoted a shift toward Th1 immune response instead of Th2. Furthermore, Tg infection promoted the expansion of preponderant flora and Clostridiaceae was identified as a feature marker in the GM of the co-infection group. Redundancy analysis (RDA)/canonical correspondence analysis (CCA) results showed that liver fibrosis, Th1/Th2 cytokines were significantly correlated (P < 0.05) with the GM compositions. Tg infection inhibits hepatic fibrosis by downregulating Th2 immune response against Sj infection, and further promotes the GM shifts through “gut–liver axis” in the murine hosts. Our study may provide insights into potential anti-fibrosis strategies in co-infection individuals." @default.
• W3016947102 created "2020-04-24" @default.
• W3016947102 creator A5002150450 @default.
• W3016947102 creator A5003500927 @default.
• W3016947102 creator A5009638318 @default.
• W3016947102 creator A5013639826 @default.
• W3016947102 creator A5015504034 @default.
• W3016947102 creator A5041679889 @default.
• W3016947102 creator A5079537228 @default.
• W3016947102 creator A5079541977 @default.
• W3016947102 date "2020-04-14" @default.
• W3016947102 modified "2023-10-17" @default.
• W3016947102 title "Prior Toxoplasma Gondii Infection Ameliorates Liver Fibrosis Induced by Schistosoma Japonicum through Inhibiting Th2 Response and Improving Balance of Intestinal Flora in Mice" @default.
• W3016947102 cites W113322724 @default.
• W3016947102 cites W1964027278 @default.
• W3016947102 cites W1969632653 @default.
• W3016947102 cites W1990976625 @default.
• W3016947102 cites W2004506978 @default.
• W3016947102 cites W2004774344 @default.
• W3016947102 cites W2005676220 @default.
• W3016947102 cites W2015703705 @default.
• W3016947102 cites W2022836778 @default.
• W3016947102 cites W2023245937 @default.
• W3016947102 cites W2035141288 @default.
• W3016947102 cites W2047759150 @default.
• W3016947102 cites W2053923770 @default.
• W3016947102 cites W2057335375 @default.
• W3016947102 cites W2060656527 @default.
• W3016947102 cites W2074177784 @default.
• W3016947102 cites W2090336467 @default.
• W3016947102 cites W2099899075 @default.
• W3016947102 cites W2107879555 @default.
• W3016947102 cites W2114393797 @default.
• W3016947102 cites W2115033553 @default.
• W3016947102 cites W2140164106 @default.
• W3016947102 cites W2142939879 @default.
• W3016947102 cites W2149915109 @default.
• W3016947102 cites W2409388024 @default.
• W3016947102 cites W2443189794 @default.
• W3016947102 cites W2519959682 @default.
• W3016947102 cites W2591924918 @default.
• W3016947102 cites W2609006221 @default.
• W3016947102 cites W2644265820 @default.
• W3016947102 cites W2658082256 @default.
• W3016947102 cites W2738153183 @default.
• W3016947102 cites W2750407206 @default.
• W3016947102 cites W2761677880 @default.
• W3016947102 cites W2765991946 @default.
• W3016947102 cites W2782685575 @default.
• W3016947102 cites W278900642 @default.
• W3016947102 cites W2795346480 @default.
• W3016947102 cites W2809969688 @default.
• W3016947102 cites W2811029037 @default.
• W3016947102 cites W2885492105 @default.
• W3016947102 cites W2885535623 @default.
• W3016947102 cites W2891879417 @default.
• W3016947102 cites W2902688637 @default.
• W3016947102 cites W2902937135 @default.
• W3016947102 cites W2931716796 @default.
• W3016947102 cites W2942659083 @default.
• W3016947102 cites W2951005150 @default.
• W3016947102 cites W2952631484 @default.
• W3016947102 cites W2955605041 @default.
• W3016947102 cites W2970622816 @default.
• W3016947102 cites W2972930822 @default.
• W3016947102 cites W2983121775 @default.
• W3016947102 cites W4229852248 @default.
• W3016947102 cites W4254379027 @default.
• W3016947102 doi "https://doi.org/10.3390/ijms21082711" @default.
• W3016947102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7216211" @default.
• W3016947102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32295161" @default.
• W3016947102 hasPublicationYear "2020" @default.
• W3016947102 type Work @default.
• W3016947102 sameAs 3016947102 @default.
• W3016947102 citedByCount "11" @default.
• W3016947102 countsByYear W30169471022020 @default.
• W3016947102 countsByYear W30169471022021 @default.
• W3016947102 countsByYear W30169471022022 @default.
• W3016947102 countsByYear W30169471022023 @default.
• W3016947102 crossrefType "journal-article" @default.
• W3016947102 hasAuthorship W3016947102A5002150450 @default.
• W3016947102 hasAuthorship W3016947102A5003500927 @default.
• W3016947102 hasAuthorship W3016947102A5009638318 @default.
• W3016947102 hasAuthorship W3016947102A5013639826 @default.
• W3016947102 hasAuthorship W3016947102A5015504034 @default.
• W3016947102 hasAuthorship W3016947102A5041679889 @default.
• W3016947102 hasAuthorship W3016947102A5079537228 @default.
• W3016947102 hasAuthorship W3016947102A5079541977 @default.
• W3016947102 hasBestOaLocation W30169471021 @default.
• W3016947102 hasConcept C142724271 @default.
• W3016947102 hasConcept C159654299 @default.
• W3016947102 hasConcept C165901193 @default.
• W3016947102 hasConcept C203014093 @default.
• W3016947102 hasConcept C2776225656 @default.
• W3016947102 hasConcept C2776863245 @default.
• W3016947102 hasConcept C2777123769 @default.
• W3016947102 hasConcept C2778128430 @default.
• W3016947102 hasConcept C2778491710 @default.

• next