Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016950488> ?p ?o ?g. }
- W3016950488 endingPage "136" @default.
- W3016950488 startingPage "128" @default.
- W3016950488 abstract "Abstract Introduction Emery‐Dreifuss muscular dystrophy (EDMD) is a disease characterized by skeletal muscle wasting, major tendon contractures, and cardiac conduction defects. Mutations in the gene encoding emerin cause EDMD1. Our previous studies suggested that emerin activation of histone deacetylase 3 (HDAC3) to reduce histone 4‐lysine 5 (H4K5) acetylation (ac) is important for myogenic differentiation. Methods Pharmacological inhibitors (Nu9056, L002) of histone acetyltransferases targeting acetylated H4K5 were used to test whether increased acetylated H4K5 was responsible for the impaired differentiation seen in emerin‐deficient myogenic progenitors. Results Nu9056 and L002 rescued impaired differentiation in emerin deficiency. SRT1720, which inhibits the nicotinamide adenine dinucleotide (NAD) + ‐dependent deacetylase sirtuin 1 (SIRT1), failed to rescue myotube formation. Discussion We conclude that emerin regulation of HDAC3 activity to affect H4K5 acetylation dynamics is important for myogenic differentiation. Targeting H4K5ac dynamics represents a potential new strategy for ameliorating the skeletal muscle wasting seen in EDMD1." @default.
- W3016950488 created "2020-04-24" @default.
- W3016950488 creator A5001647035 @default.
- W3016950488 creator A5058652374 @default.
- W3016950488 creator A5061474903 @default.
- W3016950488 date "2020-05-06" @default.
- W3016950488 modified "2023-09-23" @default.
- W3016950488 title "Histone acetyltransferase inhibition rescues differentiation of emerin‐deficient myogenic progenitors" @default.
- W3016950488 cites W1965168140 @default.
- W3016950488 cites W1966339894 @default.
- W3016950488 cites W1992068901 @default.
- W3016950488 cites W2003111937 @default.
- W3016950488 cites W2010335932 @default.
- W3016950488 cites W2019622515 @default.
- W3016950488 cites W2020616174 @default.
- W3016950488 cites W2021074239 @default.
- W3016950488 cites W2022610139 @default.
- W3016950488 cites W2026206203 @default.
- W3016950488 cites W2030085171 @default.
- W3016950488 cites W2031011363 @default.
- W3016950488 cites W2034619620 @default.
- W3016950488 cites W2041599232 @default.
- W3016950488 cites W2044087195 @default.
- W3016950488 cites W2048276806 @default.
- W3016950488 cites W2077834313 @default.
- W3016950488 cites W2083441358 @default.
- W3016950488 cites W2090147884 @default.
- W3016950488 cites W2090705888 @default.
- W3016950488 cites W2094506191 @default.
- W3016950488 cites W2108564378 @default.
- W3016950488 cites W2116350182 @default.
- W3016950488 cites W2119090173 @default.
- W3016950488 cites W2119208710 @default.
- W3016950488 cites W2124015158 @default.
- W3016950488 cites W2128803395 @default.
- W3016950488 cites W2129258781 @default.
- W3016950488 cites W2149459044 @default.
- W3016950488 cites W2157443558 @default.
- W3016950488 cites W2162767519 @default.
- W3016950488 cites W2164893149 @default.
- W3016950488 cites W2197446758 @default.
- W3016950488 cites W2314800814 @default.
- W3016950488 cites W2520593876 @default.
- W3016950488 cites W2586324262 @default.
- W3016950488 cites W2763478649 @default.
- W3016950488 cites W2766996314 @default.
- W3016950488 cites W2770535166 @default.
- W3016950488 cites W2804089199 @default.
- W3016950488 cites W961024891 @default.
- W3016950488 doi "https://doi.org/10.1002/mus.26892" @default.
- W3016950488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7382944" @default.
- W3016950488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32304242" @default.
- W3016950488 hasPublicationYear "2020" @default.
- W3016950488 type Work @default.
- W3016950488 sameAs 3016950488 @default.
- W3016950488 citedByCount "5" @default.
- W3016950488 countsByYear W30169504882020 @default.
- W3016950488 countsByYear W30169504882022 @default.
- W3016950488 countsByYear W30169504882023 @default.
- W3016950488 crossrefType "journal-article" @default.
- W3016950488 hasAuthorship W3016950488A5001647035 @default.
- W3016950488 hasAuthorship W3016950488A5058652374 @default.
- W3016950488 hasAuthorship W3016950488A5061474903 @default.
- W3016950488 hasBestOaLocation W30169504882 @default.
- W3016950488 hasConcept C104317684 @default.
- W3016950488 hasConcept C119157956 @default.
- W3016950488 hasConcept C134018914 @default.
- W3016950488 hasConcept C153911025 @default.
- W3016950488 hasConcept C2778305200 @default.
- W3016950488 hasConcept C2779030066 @default.
- W3016950488 hasConcept C2779959927 @default.
- W3016950488 hasConcept C2781023310 @default.
- W3016950488 hasConcept C29512474 @default.
- W3016950488 hasConcept C54355233 @default.
- W3016950488 hasConcept C64927066 @default.
- W3016950488 hasConcept C86339819 @default.
- W3016950488 hasConcept C86803240 @default.
- W3016950488 hasConcept C95444343 @default.
- W3016950488 hasConceptScore W3016950488C104317684 @default.
- W3016950488 hasConceptScore W3016950488C119157956 @default.
- W3016950488 hasConceptScore W3016950488C134018914 @default.
- W3016950488 hasConceptScore W3016950488C153911025 @default.
- W3016950488 hasConceptScore W3016950488C2778305200 @default.
- W3016950488 hasConceptScore W3016950488C2779030066 @default.
- W3016950488 hasConceptScore W3016950488C2779959927 @default.
- W3016950488 hasConceptScore W3016950488C2781023310 @default.
- W3016950488 hasConceptScore W3016950488C29512474 @default.
- W3016950488 hasConceptScore W3016950488C54355233 @default.
- W3016950488 hasConceptScore W3016950488C64927066 @default.
- W3016950488 hasConceptScore W3016950488C86339819 @default.
- W3016950488 hasConceptScore W3016950488C86803240 @default.
- W3016950488 hasConceptScore W3016950488C95444343 @default.
- W3016950488 hasFunder F4320332161 @default.
- W3016950488 hasFunder F4320337362 @default.
- W3016950488 hasIssue "1" @default.
- W3016950488 hasLocation W30169504881 @default.
- W3016950488 hasLocation W30169504882 @default.
- W3016950488 hasLocation W30169504883 @default.