FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016968171> ?p ?o ?g. }

• W3016968171 abstract "ABSTRACT A 5’, 7-methylguanosine cap is a quintessential feature of RNA polymerase II-transcribed RNAs, and a textbook aspect of co-transcriptional RNA processing. The cap is bound by the cap-binding complex (CBC), canonically consisting of nuclear cap-binding proteins 1 and 2 (NCBP1/2). The CBC has come under renewed investigative interest in recent years due to its participation in RNA-fate decisions via interactions with RNA productive factors as well as with adapters of the degradative RNA exosome - including the proteins SRRT (a.k.a. ARS2) and ZC3H18, and macromolecular assemblies such as the nuclear exosome targeting (NEXT) complex and the poly(A) exosome targeting (PAXT) connection. A novel cap-binding protein, NCBP3, was recently proposed to form an alternative, non-canonical CBC together with NCBP1, and to interact with the canonical CBC along with the protein SRRT. The theme of post-transcriptional RNA fate, and how it relates to co-transcriptional ribonucleoprotein assembly is abundant with complicated, ambiguous, and likely incomplete models. In an effort to clarify the compositions of NCBP1-, 2-, and 3-related macromolecular assemblies, including their intersections and differences, we have applied an affinity capture-based interactome screening approach, where the experimental design and data processing have been modified and updated to identify interactome differences between targets under a range of experimental conditions, in the context of label-free quantitative mass spectrometry. This study generated a comprehensive view of NCBP-protein interactions in the ribonucleoprotein context and demonstrates the potential of our approach to benefit the interpretation of complex biological pathways." @default.
• W3016968171 created "2020-04-24" @default.
• W3016968171 creator A5003631055 @default.
• W3016968171 creator A5006726822 @default.
• W3016968171 creator A5029463415 @default.
• W3016968171 creator A5030183640 @default.
• W3016968171 creator A5030974127 @default.
• W3016968171 creator A5047152636 @default.
• W3016968171 creator A5053613016 @default.
• W3016968171 creator A5065548847 @default.
• W3016968171 creator A5065792746 @default.
• W3016968171 creator A5076439669 @default.
• W3016968171 creator A5083861536 @default.
• W3016968171 creator A5084513610 @default.
• W3016968171 date "2020-04-21" @default.
• W3016968171 modified "2023-10-18" @default.
• W3016968171 title "Affinity proteomic dissection of the human nuclear cap-binding complex interactome" @default.
• W3016968171 cites W1540853973 @default.
• W3016968171 cites W1611787727 @default.
• W3016968171 cites W1838945435 @default.
• W3016968171 cites W1966735041 @default.
• W3016968171 cites W1977416347 @default.
• W3016968171 cites W1980135044 @default.
• W3016968171 cites W1984883254 @default.
• W3016968171 cites W1990640571 @default.
• W3016968171 cites W1996998613 @default.
• W3016968171 cites W1997203592 @default.
• W3016968171 cites W2000403772 @default.
• W3016968171 cites W2010116656 @default.
• W3016968171 cites W2022546135 @default.
• W3016968171 cites W2024209903 @default.
• W3016968171 cites W2029425286 @default.
• W3016968171 cites W2030368309 @default.
• W3016968171 cites W2030626178 @default.
• W3016968171 cites W2040174498 @default.
• W3016968171 cites W2042039207 @default.
• W3016968171 cites W2043756613 @default.
• W3016968171 cites W2046828533 @default.
• W3016968171 cites W2047001514 @default.
• W3016968171 cites W2056782561 @default.
• W3016968171 cites W2060807817 @default.
• W3016968171 cites W2066835429 @default.
• W3016968171 cites W2076304484 @default.
• W3016968171 cites W2081023618 @default.
• W3016968171 cites W2083088823 @default.
• W3016968171 cites W2092048230 @default.
• W3016968171 cites W2094618951 @default.
• W3016968171 cites W2096767063 @default.
• W3016968171 cites W2099302171 @default.
• W3016968171 cites W2108130094 @default.
• W3016968171 cites W2108549889 @default.
• W3016968171 cites W2110010240 @default.
• W3016968171 cites W2125141425 @default.
• W3016968171 cites W2136565487 @default.
• W3016968171 cites W2145001669 @default.
• W3016968171 cites W2148393113 @default.
• W3016968171 cites W2162909198 @default.
• W3016968171 cites W2167004527 @default.
• W3016968171 cites W2186166869 @default.
• W3016968171 cites W2211150216 @default.
• W3016968171 cites W2222339343 @default.
• W3016968171 cites W2329251489 @default.
• W3016968171 cites W2373831850 @default.
• W3016968171 cites W2463195069 @default.
• W3016968171 cites W2542901068 @default.
• W3016968171 cites W2544360569 @default.
• W3016968171 cites W2553662173 @default.
• W3016968171 cites W2559839830 @default.
• W3016968171 cites W2576357496 @default.
• W3016968171 cites W2594208084 @default.
• W3016968171 cites W2595017657 @default.
• W3016968171 cites W2744206279 @default.
• W3016968171 cites W2744991319 @default.
• W3016968171 cites W2767532322 @default.
• W3016968171 cites W2781506206 @default.
• W3016968171 cites W2781922600 @default.
• W3016968171 cites W2782254108 @default.
• W3016968171 cites W2801582631 @default.
• W3016968171 cites W2899760200 @default.
• W3016968171 cites W2935332326 @default.
• W3016968171 cites W3003405284 @default.
• W3016968171 cites W4214807762 @default.
• W3016968171 cites W4243979784 @default.
• W3016968171 cites W4254324080 @default.
• W3016968171 cites W4256563997 @default.
• W3016968171 doi "https://doi.org/10.1101/2020.04.20.048470" @default.
• W3016968171 hasPublicationYear "2020" @default.
• W3016968171 type Work @default.
• W3016968171 sameAs 3016968171 @default.
• W3016968171 citedByCount "0" @default.
• W3016968171 crossrefType "posted-content" @default.
• W3016968171 hasAuthorship W3016968171A5003631055 @default.
• W3016968171 hasAuthorship W3016968171A5006726822 @default.
• W3016968171 hasAuthorship W3016968171A5029463415 @default.
• W3016968171 hasAuthorship W3016968171A5030183640 @default.
• W3016968171 hasAuthorship W3016968171A5030974127 @default.
• W3016968171 hasAuthorship W3016968171A5047152636 @default.
• W3016968171 hasAuthorship W3016968171A5053613016 @default.
• W3016968171 hasAuthorship W3016968171A5065548847 @default.
• W3016968171 hasAuthorship W3016968171A5065792746 @default.

• next