Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016978129> ?p ?o ?g. }
- W3016978129 endingPage "7199" @default.
- W3016978129 startingPage "7194" @default.
- W3016978129 abstract "Tyrosinase (TYR) is a crucial enzyme involved in melanogenesis, and its overexpression is closely associated with melanoma. To precisely monitor intracellular TYR activity, remote control of a molecule imaging tool is highly meaningful but remains to be explored. In this work, we present the first photocaged tyrosinase fluorogenic probe by caging the substrate of the enzymatic probe with a photolabile group. Because of the sequential light and enzyme-activation feature, this probe exhibits photocontrollable turn on response toward TYR with good selectivity and high sensitivity (detection limit: 0.08 U/mL). Fluorescence imaging results validate that the caged probe possesses the capability of visualizing intracellular endogenous tyrosinase activity in a photocontrol fashion, thus offering a promising molecule imaging tool for investigating TYR-related physiological function and pathological role. Moreover, our sequential activation strategy has great potential for developing more photocontrollable enzymatic fluorogenic probes with spatiotemporal resolution." @default.
- W3016978129 created "2020-04-24" @default.
- W3016978129 creator A5046307084 @default.
- W3016978129 creator A5050344248 @default.
- W3016978129 creator A5056113333 @default.
- W3016978129 creator A5073628821 @default.
- W3016978129 creator A5074382953 @default.
- W3016978129 creator A5083809384 @default.
- W3016978129 creator A5089742133 @default.
- W3016978129 date "2020-04-20" @default.
- W3016978129 modified "2023-10-17" @default.
- W3016978129 title "Substrate-Photocaged Enzymatic Fluorogenic Probe Enabling Sequential Activation for Light-Controllable Monitoring of Intracellular Tyrosinase Activity" @default.
- W3016978129 cites W1986213291 @default.
- W3016978129 cites W2003951103 @default.
- W3016978129 cites W2024811628 @default.
- W3016978129 cites W2025395772 @default.
- W3016978129 cites W2060415328 @default.
- W3016978129 cites W2064669963 @default.
- W3016978129 cites W2084311353 @default.
- W3016978129 cites W2105915844 @default.
- W3016978129 cites W2109426520 @default.
- W3016978129 cites W2129631462 @default.
- W3016978129 cites W2149888617 @default.
- W3016978129 cites W2162730446 @default.
- W3016978129 cites W2238501235 @default.
- W3016978129 cites W2332897967 @default.
- W3016978129 cites W2538680875 @default.
- W3016978129 cites W2580268017 @default.
- W3016978129 cites W2738457770 @default.
- W3016978129 cites W2749724577 @default.
- W3016978129 cites W2763918550 @default.
- W3016978129 cites W2774669078 @default.
- W3016978129 cites W2780750565 @default.
- W3016978129 cites W2787143697 @default.
- W3016978129 cites W2793526382 @default.
- W3016978129 cites W2802076314 @default.
- W3016978129 cites W2805500699 @default.
- W3016978129 cites W2862285183 @default.
- W3016978129 cites W2883434688 @default.
- W3016978129 cites W2888689489 @default.
- W3016978129 cites W2895198173 @default.
- W3016978129 cites W2900711064 @default.
- W3016978129 cites W2901220654 @default.
- W3016978129 cites W2949869073 @default.
- W3016978129 cites W2959584567 @default.
- W3016978129 cites W2969369233 @default.
- W3016978129 cites W2987048414 @default.
- W3016978129 cites W3006657217 @default.
- W3016978129 doi "https://doi.org/10.1021/acs.analchem.0c00746" @default.
- W3016978129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32309931" @default.
- W3016978129 hasPublicationYear "2020" @default.
- W3016978129 type Work @default.
- W3016978129 sameAs 3016978129 @default.
- W3016978129 citedByCount "41" @default.
- W3016978129 countsByYear W30169781292020 @default.
- W3016978129 countsByYear W30169781292021 @default.
- W3016978129 countsByYear W30169781292022 @default.
- W3016978129 countsByYear W30169781292023 @default.
- W3016978129 crossrefType "journal-article" @default.
- W3016978129 hasAuthorship W3016978129A5046307084 @default.
- W3016978129 hasAuthorship W3016978129A5050344248 @default.
- W3016978129 hasAuthorship W3016978129A5056113333 @default.
- W3016978129 hasAuthorship W3016978129A5073628821 @default.
- W3016978129 hasAuthorship W3016978129A5074382953 @default.
- W3016978129 hasAuthorship W3016978129A5083809384 @default.
- W3016978129 hasAuthorship W3016978129A5089742133 @default.
- W3016978129 hasConcept C111368507 @default.
- W3016978129 hasConcept C12554922 @default.
- W3016978129 hasConcept C127313418 @default.
- W3016978129 hasConcept C181199279 @default.
- W3016978129 hasConcept C185592680 @default.
- W3016978129 hasConcept C2777289219 @default.
- W3016978129 hasConcept C2994592520 @default.
- W3016978129 hasConcept C55493867 @default.
- W3016978129 hasConcept C79879829 @default.
- W3016978129 hasConcept C86803240 @default.
- W3016978129 hasConcept C87554066 @default.
- W3016978129 hasConceptScore W3016978129C111368507 @default.
- W3016978129 hasConceptScore W3016978129C12554922 @default.
- W3016978129 hasConceptScore W3016978129C127313418 @default.
- W3016978129 hasConceptScore W3016978129C181199279 @default.
- W3016978129 hasConceptScore W3016978129C185592680 @default.
- W3016978129 hasConceptScore W3016978129C2777289219 @default.
- W3016978129 hasConceptScore W3016978129C2994592520 @default.
- W3016978129 hasConceptScore W3016978129C55493867 @default.
- W3016978129 hasConceptScore W3016978129C79879829 @default.
- W3016978129 hasConceptScore W3016978129C86803240 @default.
- W3016978129 hasConceptScore W3016978129C87554066 @default.
- W3016978129 hasFunder F4320321001 @default.
- W3016978129 hasFunder F4320333642 @default.
- W3016978129 hasIssue "10" @default.
- W3016978129 hasLocation W30169781291 @default.
- W3016978129 hasOpenAccess W3016978129 @default.
- W3016978129 hasPrimaryLocation W30169781291 @default.
- W3016978129 hasRelatedWork W1966418295 @default.
- W3016978129 hasRelatedWork W1977305841 @default.
- W3016978129 hasRelatedWork W1999810095 @default.
- W3016978129 hasRelatedWork W2001916175 @default.