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• W3016983204 abstract "Numerous materials have been developed to try and harness the antimicrobial properties of nitric oxide (NO). However, the short half-life and reactivity of NO have made precise, tunable delivery difficult. As such, conventional methodologies have generally relied on donors that spontaneously release NO at different rates, and delivery profiles have largely been constrained to decaying dynamics. In recent years, the possibility of finely controlling NO release, for instance with light, has become achievable and this raises the question of how delivery dynamics influence therapeutic potential. Here we investigated this relationship using Escherichia coli as a model organism and an approach that incorporated both experimentation and mathematical modeling. We found that the best performing delivery mode was dependent on the NO payload, and developed a mathematical model to quantitatively dissect those observations. Those analyses suggested that the duration of respiratory inhibition was a major determinant of NO-induced growth inhibition. Inspired by this, we constructed a delivery schedule that leveraged that insight to extend the antimicrobial activity of NO far beyond what was achievable by traditional delivery dynamics. Collectively, these data and analyses suggest that the delivery dynamics of NO have a considerable impact on its ability to achieve and maintain bacteriostasis." @default.
• W3016983204 created "2020-04-24" @default.
• W3016983204 creator A5009111953 @default.
• W3016983204 creator A5026472419 @default.
• W3016983204 date "2020-04-17" @default.
• W3016983204 modified "2023-09-25" @default.
• W3016983204 title "Quantitative Modeling Extends the Antibacterial Activity of Nitric Oxide" @default.
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• W3016983204 doi "https://doi.org/10.3389/fphys.2020.00330" @default.
• W3016983204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7181900" @default.
• W3016983204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32362838" @default.
• W3016983204 hasPublicationYear "2020" @default.
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