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• W3016985143 abstract "Abstract Novel disease emergence is often associated with changes in pathogen traits that enable pathogen colonisation, persistence and transmission in the novel host environment. While understanding the mechanisms underlying disease emergence is likely to have critical implications for preventing infectious outbreaks, such knowledge is often based on studies of viral pathogens, despite the fact that bacterial pathogens may exhibit very different life histories. Here, we investigate the ability of epizootic outbreak strains of the bacterial pathogen, Mycoplasma gallisepticum , which jumped from poultry into North American house finches ( Haemorhous mexicanus ), to interact with model avian cells. We found that house finch epizootic outbreak strains of M. gallisepticum displayed a greater ability to adhere to, invade, persist within and exit from cultured chicken embryonic fibroblasts, than the reference virulent (R_low) and attenuated (R_high) poultry strains. Furthermore, unlike the poultry strains, the house finch epizootic outbreak strain HF_1994 displayed a striking lack of cytotoxicity, even exerting a cytoprotective effect on avian cells. Our results suggest that, at epizootic outbreak in house finches, M. gallisepticum was particularly adept at using the intra-cellular environment, which may have facilitated colonisation, dissemination and immune evasion within the novel finch host. Whether this high-invasion phenotype is similarly displayed in interactions with house finch cells, and whether it contributed to the success of the host shift, remains to be determined." @default.
• W3016985143 created "2020-04-24" @default.
• W3016985143 creator A5030755565 @default.
• W3016985143 creator A5042655145 @default.
• W3016985143 creator A5081273924 @default.
• W3016985143 date "2020-04-22" @default.
• W3016985143 modified "2023-09-24" @default.
• W3016985143 title "Multiple differences in pathogen-host cell interactions following a bacterial host shift" @default.
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• W3016985143 doi "https://doi.org/10.1038/s41598-020-63714-0" @default.
• W3016985143 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7176683" @default.
• W3016985143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32322086" @default.
• W3016985143 hasPublicationYear "2020" @default.
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