FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016988123> ?p ?o ?g. }

• W3016988123 endingPage "476" @default.
• W3016988123 startingPage "468" @default.
• W3016988123 abstract "As a zoonotic disease, ovine contagious pustular dermatitis (Orf) is a serious threat to sheep as well as humans. Orf virus (ORFV) interferon resistance protein (VIR) is the principal virulence protein that encodes a dsRNA-binding protein to inhibit host antiviral response. p53 is one of the key proteins of the host antiviral innate immunity. It not only enhances type I interferon secretion but also induces apoptosis in infected cells, and plays a crucial role in the immune response against various viral infections. However, it remains to be elucidated what role p53 plays in ORFV replication and whether ORFV's own protein VIR regulates p53 expression to promote self-replication. In this study, we showed that p53 has an antiviral effect on ORFV and can inhibit ORFV replication. In addition, ORFV nonstructural protein VIR interacts with p53 and degrades p53, which inhibits p53-mediated positive regulation of downstream antiviral genes. This study provides new insight into the immune evasion mediated by ORFV and identifies VIR as an antagonistic factor for ORFV to evade the antiviral response." @default.
• W3016988123 created "2020-04-24" @default.
• W3016988123 creator A5001799309 @default.
• W3016988123 creator A5013704631 @default.
• W3016988123 creator A5027390010 @default.
• W3016988123 creator A5044672875 @default.
• W3016988123 creator A5057650776 @default.
• W3016988123 creator A5066217007 @default.
• W3016988123 creator A5081183372 @default.
• W3016988123 creator A5084603057 @default.
• W3016988123 creator A5085673463 @default.
• W3016988123 date "2020-07-01" @default.
• W3016988123 modified "2023-09-26" @default.
• W3016988123 title "Orf Virus <i>VIR</i> Antagonizes p53-Mediated Antiviral Effects to Facilitate Viral Replication" @default.
• W3016988123 cites W123325772 @default.
• W3016988123 cites W1525530602 @default.
• W3016988123 cites W2004083964 @default.
• W3016988123 cites W2004126169 @default.
• W3016988123 cites W2004681996 @default.
• W3016988123 cites W2009332226 @default.
• W3016988123 cites W2009737801 @default.
• W3016988123 cites W2035658420 @default.
• W3016988123 cites W2044489330 @default.
• W3016988123 cites W2046669185 @default.
• W3016988123 cites W2057624204 @default.
• W3016988123 cites W2058757643 @default.
• W3016988123 cites W2069907608 @default.
• W3016988123 cites W2072042555 @default.
• W3016988123 cites W2080428007 @default.
• W3016988123 cites W2089082314 @default.
• W3016988123 cites W2098037167 @default.
• W3016988123 cites W2119047742 @default.
• W3016988123 cites W2134543906 @default.
• W3016988123 cites W2138657695 @default.
• W3016988123 cites W2146024346 @default.
• W3016988123 cites W2161105855 @default.
• W3016988123 cites W2169518072 @default.
• W3016988123 cites W2525521266 @default.
• W3016988123 cites W2588753608 @default.
• W3016988123 cites W2790493421 @default.
• W3016988123 cites W2887533202 @default.
• W3016988123 doi "https://doi.org/10.1089/vim.2019.0189" @default.
• W3016988123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32315577" @default.
• W3016988123 hasPublicationYear "2020" @default.
• W3016988123 type Work @default.
• W3016988123 sameAs 3016988123 @default.
• W3016988123 citedByCount "3" @default.
• W3016988123 countsByYear W30169881232021 @default.
• W3016988123 countsByYear W30169881232022 @default.
• W3016988123 crossrefType "journal-article" @default.
• W3016988123 hasAuthorship W3016988123A5001799309 @default.
• W3016988123 hasAuthorship W3016988123A5013704631 @default.
• W3016988123 hasAuthorship W3016988123A5027390010 @default.
• W3016988123 hasAuthorship W3016988123A5044672875 @default.
• W3016988123 hasAuthorship W3016988123A5057650776 @default.
• W3016988123 hasAuthorship W3016988123A5066217007 @default.
• W3016988123 hasAuthorship W3016988123A5081183372 @default.
• W3016988123 hasAuthorship W3016988123A5084603057 @default.
• W3016988123 hasAuthorship W3016988123A5085673463 @default.
• W3016988123 hasBestOaLocation W30169881231 @default.
• W3016988123 hasConcept C104317684 @default.
• W3016988123 hasConcept C136449434 @default.
• W3016988123 hasConcept C140704245 @default.
• W3016988123 hasConcept C159047783 @default.
• W3016988123 hasConcept C166703698 @default.
• W3016988123 hasConcept C203014093 @default.
• W3016988123 hasConcept C2191507 @default.
• W3016988123 hasConcept C2522874641 @default.
• W3016988123 hasConcept C2776178377 @default.
• W3016988123 hasConcept C2776746152 @default.
• W3016988123 hasConcept C54355233 @default.
• W3016988123 hasConcept C60987743 @default.
• W3016988123 hasConcept C67705224 @default.
• W3016988123 hasConcept C86803240 @default.
• W3016988123 hasConcept C8891405 @default.
• W3016988123 hasConcept C9173399 @default.
• W3016988123 hasConceptScore W3016988123C104317684 @default.
• W3016988123 hasConceptScore W3016988123C136449434 @default.
• W3016988123 hasConceptScore W3016988123C140704245 @default.
• W3016988123 hasConceptScore W3016988123C159047783 @default.
• W3016988123 hasConceptScore W3016988123C166703698 @default.
• W3016988123 hasConceptScore W3016988123C203014093 @default.
• W3016988123 hasConceptScore W3016988123C2191507 @default.
• W3016988123 hasConceptScore W3016988123C2522874641 @default.
• W3016988123 hasConceptScore W3016988123C2776178377 @default.
• W3016988123 hasConceptScore W3016988123C2776746152 @default.
• W3016988123 hasConceptScore W3016988123C54355233 @default.
• W3016988123 hasConceptScore W3016988123C60987743 @default.
• W3016988123 hasConceptScore W3016988123C67705224 @default.
• W3016988123 hasConceptScore W3016988123C86803240 @default.
• W3016988123 hasConceptScore W3016988123C8891405 @default.
• W3016988123 hasConceptScore W3016988123C9173399 @default.
• W3016988123 hasIssue "6" @default.
• W3016988123 hasLocation W30169881231 @default.
• W3016988123 hasOpenAccess W3016988123 @default.
• W3016988123 hasPrimaryLocation W30169881231 @default.
• W3016988123 hasRelatedWork W1881662972 @default.
• W3016988123 hasRelatedWork W2024956434 @default.

• next