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- W3017004106 abstract "Abstract Cumulus cells and mural granulosa cells (MGCs) play distinct roles during follicular development, and normal development of these cell lineages is critical for the female fertility. Transcriptomic diversification between the two cell lineages is obviously a critical mechanism for their functional diversification; however, the transcriptional regulators responsible for this event have not been fully defined. In this study, we sought to identify key transcriptional regulators responsible for the differential gene expression between the two cell lineages. In silico analysis of transcriptomic comparison between cumulus cells and MGCs identified several candidate regulators responsible for the diversification of the two cell lineages. Among them, we herein focused on forkhead box L2 (FOXL2) and showed that expressions of FOXL2 as well as its target transcripts were differentially regulated between cumulus cells and MGCs. The lower expression of FOXL2 in cumulus cells seemed to be due to the suppression by oocyte-derived paracrine signals. These results suggest that FOXL2 is one of the critical transcription factors that determine cumulus cell and MGC lineages under the control of oocytes." @default.
- W3017004106 created "2020-04-24" @default.
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- W3017004106 date "2020-04-20" @default.
- W3017004106 modified "2023-10-15" @default.
- W3017004106 title "Oocytes suppress FOXL2 expression in cumulus cells in mice†" @default.
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- W3017004106 doi "https://doi.org/10.1093/biolre/ioaa054" @default.
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