FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3017005095> ?p ?o ?g. }

• W3017005095 endingPage "1" @default.
• W3017005095 startingPage "1" @default.
• W3017005095 abstract "Traumatic brain injuries (TBI) are a tragic yet surprisingly common problem throughout the world. In the United States alone, 2.8 million people a year are diagnosed with a TBI. TBI causes cellular death and dysfunction within the brain that is connected with cognitive and behavioral dysfunction both clinically and experimentally. The controlled cortical impact (CCI) model is a well characterized contusion model of TBI that emulates both motor and cognitive deficits in addition to cell loss within the dentate gyrus of the hippocampus. Following CCI there is an early loss of the immature neuron population in the subgranular zone of the dentate gyrus followed by a compensatory increase in newborn neurons. Additionally, there is increased glial reactivity in response to injury. Of these newborn neurons, only a small portion survive and incorporate into the granular cell layer (GCL) of the dentate gyrus. However, the surviving trauma-born neurons display stunted growth and reduced arborization, and not many make it to a fully functional form. Previous research shows that treatment with insulin-like growth factor-1 (IGF-1) conveys behavioral improvements and increases the survival of doublecortin (DCX) positive trauma-born neurons with improved dendritic arborization. In the current study, C57BL/6J mice underwent a CCI or a sham injury and were administered IGF-1 (3mg/mg) or vehicle by intracerebroventricular injection (nCCI&IGF-1 = 7 | nCCI&Veh = 8 | nSham&IGF-1 = 4 | nSham&Veh = 4) for 7 days following injury. Animals were euthanized 7 days after injury, and the brain was collected, processed, and sectioned at a thickness of 40mm for immunohistochemistry. Tissue was then immuno-labeled for DCX, a marker of immature neurons, and glial fibrillary acidic protein (GFAP), a marker of astrocytes in the brain, and imaged. We observed that the trauma-born neurons of CCI injured mice treated with IGF-1 migrate from the subgranular zone and into the outer 2/3rds of the GCL more frequently than do those observed in animals treated with vehicle. During development, GFAP positive cells send processes out that serve as a scaffolding by which immature neurons can migrate. As such, we hypothesized that after TBI, immature neurons migrate through the GCL by utilizing GFAP positive processes, and that IGF-1 would increase the number of processes projecting through the GCL compared to vehicle treated animals. We assessed the number of GFAP positive processes projecting into the GCL by counting the number of processes per millimeter in three brain sections collected from the epicenter of injury. Our findings suggest that there is an increase in GFAP processes following CCI, but treatment with IGF-1 did not increase the number of these processes. Our findings suggest that increased migration seen with IGF-1 treatment does not occur along glial processes, or that this is not the only means by which DCX positive cells are able to migrate after injury. Support or Funding Information Funded through American Physiological Society 2019 UGSRF Fellowship" @default.
• W3017005095 created "2020-04-24" @default.
• W3017005095 creator A5000750183 @default.
• W3017005095 creator A5049740892 @default.
• W3017005095 creator A5053936539 @default.
• W3017005095 creator A5073052039 @default.
• W3017005095 date "2020-04-01" @default.
• W3017005095 modified "2023-09-26" @default.
• W3017005095 title "Insulin‐like Growth Factor‐1 Treatment of Experimental Traumatic Brain Injury Increases Newborn Neuron Migration Through the Granular Cell Layer" @default.
• W3017005095 doi "https://doi.org/10.1096/fasebj.2020.34.s1.05804" @default.
• W3017005095 hasPublicationYear "2020" @default.
• W3017005095 type Work @default.
• W3017005095 sameAs 3017005095 @default.
• W3017005095 citedByCount "0" @default.
• W3017005095 crossrefType "journal-article" @default.
• W3017005095 hasAuthorship W3017005095A5000750183 @default.
• W3017005095 hasAuthorship W3017005095A5049740892 @default.
• W3017005095 hasAuthorship W3017005095A5053936539 @default.
• W3017005095 hasAuthorship W3017005095A5073052039 @default.
• W3017005095 hasBestOaLocation W30170050951 @default.
• W3017005095 hasConcept C118552586 @default.
• W3017005095 hasConcept C126322002 @default.
• W3017005095 hasConcept C134018914 @default.
• W3017005095 hasConcept C136834591 @default.
• W3017005095 hasConcept C15744967 @default.
• W3017005095 hasConcept C169760540 @default.
• W3017005095 hasConcept C2776464000 @default.
• W3017005095 hasConcept C2777542384 @default.
• W3017005095 hasConcept C2778794669 @default.
• W3017005095 hasConcept C2781017439 @default.
• W3017005095 hasConcept C2781161787 @default.
• W3017005095 hasConcept C2781176699 @default.
• W3017005095 hasConcept C2781461022 @default.
• W3017005095 hasConcept C28328180 @default.
• W3017005095 hasConcept C2908647359 @default.
• W3017005095 hasConcept C42219234 @default.
• W3017005095 hasConcept C4746552 @default.
• W3017005095 hasConcept C54355233 @default.
• W3017005095 hasConcept C71924100 @default.
• W3017005095 hasConcept C86803240 @default.
• W3017005095 hasConcept C99454951 @default.
• W3017005095 hasConceptScore W3017005095C118552586 @default.
• W3017005095 hasConceptScore W3017005095C126322002 @default.
• W3017005095 hasConceptScore W3017005095C134018914 @default.
• W3017005095 hasConceptScore W3017005095C136834591 @default.
• W3017005095 hasConceptScore W3017005095C15744967 @default.
• W3017005095 hasConceptScore W3017005095C169760540 @default.
• W3017005095 hasConceptScore W3017005095C2776464000 @default.
• W3017005095 hasConceptScore W3017005095C2777542384 @default.
• W3017005095 hasConceptScore W3017005095C2778794669 @default.
• W3017005095 hasConceptScore W3017005095C2781017439 @default.
• W3017005095 hasConceptScore W3017005095C2781161787 @default.
• W3017005095 hasConceptScore W3017005095C2781176699 @default.
• W3017005095 hasConceptScore W3017005095C2781461022 @default.
• W3017005095 hasConceptScore W3017005095C28328180 @default.
• W3017005095 hasConceptScore W3017005095C2908647359 @default.
• W3017005095 hasConceptScore W3017005095C42219234 @default.
• W3017005095 hasConceptScore W3017005095C4746552 @default.
• W3017005095 hasConceptScore W3017005095C54355233 @default.
• W3017005095 hasConceptScore W3017005095C71924100 @default.
• W3017005095 hasConceptScore W3017005095C86803240 @default.
• W3017005095 hasConceptScore W3017005095C99454951 @default.
• W3017005095 hasIssue "S1" @default.
• W3017005095 hasLocation W30170050951 @default.
• W3017005095 hasOpenAccess W3017005095 @default.
• W3017005095 hasPrimaryLocation W30170050951 @default.
• W3017005095 hasRelatedWork W1487628011 @default.
• W3017005095 hasRelatedWork W1805625510 @default.
• W3017005095 hasRelatedWork W1998040264 @default.
• W3017005095 hasRelatedWork W2034160931 @default.
• W3017005095 hasRelatedWork W2044179638 @default.
• W3017005095 hasRelatedWork W2077156703 @default.
• W3017005095 hasRelatedWork W2136472021 @default.
• W3017005095 hasRelatedWork W2166559804 @default.
• W3017005095 hasRelatedWork W3031256461 @default.
• W3017005095 hasRelatedWork W4317810051 @default.
• W3017005095 hasVolume "34" @default.
• W3017005095 isParatext "false" @default.
• W3017005095 isRetracted "false" @default.
• W3017005095 magId "3017005095" @default.
• W3017005095 workType "article" @default.