Matches in SemOpenAlex for { <https://semopenalex.org/work/W3017041452> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3017041452 abstract "Abstract Background Interleukin (IL)‐1 is a cytokine superfamily, which involved in the inflammatory process and immune response in human body. IL‐1 receptor antagonist ( IL1RN ) has been found to be associated with risk of lumbar disk herniation (LDH) in Finland samples. However, to date, there was no investigation focus on the polymorphisms of IL1RN in Chinese Han LDH patient. Materials and Methods We conducted a case–control study based on 498 LDH patients and 463 controls. Five single‐nucleotide polymorphisms (SNPs) in IL1RN were genotyped. Results As a result, we found that the AG and GG genotypes of rs3181052 were associated with decreased risk LDH under the dominant model (OR = 0.74, 95%CI: 0.57–0.96, p = .025). In the stratification analysis, the frequency of the “A” allele of rs17042888 was significantly lower in elder LDH cases than in controls (OR = 0.723, 95%CI: 0.544–0.961, p = .025). In addition, the AG and AA genotypes of rs17042888 were associated with decreased risk of LDH in elder group under the dominant model (OR = 0.69, 95%CI: 0.49–0.98, p = .038). The GG genotype of rs315919 was identified have correlation with decreased risk of LDH in elder group under the recessive model (OR = 0.60, 95%CI: 0.37–0.97, p = .034). Conclusions Our data showed that IL1RN may be a susceptibility gene for risk of LDH in Chinese Han population." @default.
- W3017041452 created "2020-04-24" @default.
- W3017041452 creator A5001514460 @default.
- W3017041452 creator A5006058281 @default.
- W3017041452 creator A5009856352 @default.
- W3017041452 creator A5015959421 @default.
- W3017041452 creator A5016463853 @default.
- W3017041452 creator A5048169926 @default.
- W3017041452 creator A5063152781 @default.
- W3017041452 date "2020-04-21" @default.
- W3017041452 modified "2023-09-27" @default.
- W3017041452 title "Genetic polymorphisms of <i>IL1RN</i> were associated with lumbar disk herniation risk in a Chinese Han population" @default.
- W3017041452 cites W1505597474 @default.
- W3017041452 cites W1524981203 @default.
- W3017041452 cites W1856707437 @default.
- W3017041452 cites W1930449800 @default.
- W3017041452 cites W1964651930 @default.
- W3017041452 cites W1985581425 @default.
- W3017041452 cites W1987594513 @default.
- W3017041452 cites W2023631091 @default.
- W3017041452 cites W2024043682 @default.
- W3017041452 cites W2040625065 @default.
- W3017041452 cites W2054123425 @default.
- W3017041452 cites W2055011209 @default.
- W3017041452 cites W2059063061 @default.
- W3017041452 cites W2060861339 @default.
- W3017041452 cites W2081996735 @default.
- W3017041452 cites W2089430956 @default.
- W3017041452 cites W2104911589 @default.
- W3017041452 cites W2104982551 @default.
- W3017041452 cites W2132630169 @default.
- W3017041452 cites W2160018962 @default.
- W3017041452 cites W2240027552 @default.
- W3017041452 cites W2403794641 @default.
- W3017041452 doi "https://doi.org/10.1002/mgg3.1247" @default.
- W3017041452 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7284030" @default.
- W3017041452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32319224" @default.
- W3017041452 hasPublicationYear "2020" @default.
- W3017041452 type Work @default.
- W3017041452 sameAs 3017041452 @default.
- W3017041452 citedByCount "2" @default.
- W3017041452 countsByYear W30170414522022 @default.
- W3017041452 countsByYear W30170414522023 @default.
- W3017041452 crossrefType "journal-article" @default.
- W3017041452 hasAuthorship W3017041452A5001514460 @default.
- W3017041452 hasAuthorship W3017041452A5006058281 @default.
- W3017041452 hasAuthorship W3017041452A5009856352 @default.
- W3017041452 hasAuthorship W3017041452A5015959421 @default.
- W3017041452 hasAuthorship W3017041452A5016463853 @default.
- W3017041452 hasAuthorship W3017041452A5048169926 @default.
- W3017041452 hasAuthorship W3017041452A5063152781 @default.
- W3017041452 hasBestOaLocation W30170414521 @default.
- W3017041452 hasConcept C104317684 @default.
- W3017041452 hasConcept C126322002 @default.
- W3017041452 hasConcept C135763542 @default.
- W3017041452 hasConcept C153209595 @default.
- W3017041452 hasConcept C180754005 @default.
- W3017041452 hasConcept C203014093 @default.
- W3017041452 hasConcept C2992519594 @default.
- W3017041452 hasConcept C54355233 @default.
- W3017041452 hasConcept C71924100 @default.
- W3017041452 hasConcept C76252995 @default.
- W3017041452 hasConcept C86803240 @default.
- W3017041452 hasConcept C90924648 @default.
- W3017041452 hasConceptScore W3017041452C104317684 @default.
- W3017041452 hasConceptScore W3017041452C126322002 @default.
- W3017041452 hasConceptScore W3017041452C135763542 @default.
- W3017041452 hasConceptScore W3017041452C153209595 @default.
- W3017041452 hasConceptScore W3017041452C180754005 @default.
- W3017041452 hasConceptScore W3017041452C203014093 @default.
- W3017041452 hasConceptScore W3017041452C2992519594 @default.
- W3017041452 hasConceptScore W3017041452C54355233 @default.
- W3017041452 hasConceptScore W3017041452C71924100 @default.
- W3017041452 hasConceptScore W3017041452C76252995 @default.
- W3017041452 hasConceptScore W3017041452C86803240 @default.
- W3017041452 hasConceptScore W3017041452C90924648 @default.
- W3017041452 hasIssue "6" @default.
- W3017041452 hasLocation W30170414521 @default.
- W3017041452 hasLocation W30170414522 @default.
- W3017041452 hasLocation W30170414523 @default.
- W3017041452 hasOpenAccess W3017041452 @default.
- W3017041452 hasPrimaryLocation W30170414521 @default.
- W3017041452 hasRelatedWork W1994630386 @default.
- W3017041452 hasRelatedWork W2003614689 @default.
- W3017041452 hasRelatedWork W2023079392 @default.
- W3017041452 hasRelatedWork W2348739934 @default.
- W3017041452 hasRelatedWork W2357736479 @default.
- W3017041452 hasRelatedWork W2361316694 @default.
- W3017041452 hasRelatedWork W2367270489 @default.
- W3017041452 hasRelatedWork W2387365530 @default.
- W3017041452 hasRelatedWork W2791177101 @default.
- W3017041452 hasRelatedWork W3055258070 @default.
- W3017041452 hasVolume "8" @default.
- W3017041452 isParatext "false" @default.
- W3017041452 isRetracted "false" @default.
- W3017041452 magId "3017041452" @default.
- W3017041452 workType "article" @default.