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- W3017043534 abstract "Purpose of review The human upper respiratory tract is colonized with a variety of bacterial microorganisms including Haemophilus influenzae . The species H. influenzae consists of typeable and nontypeable H. influenzae (NTHi) variants. Typeable H. influenzae are subdivided into types a through f, based on the polysaccharide capsule, whereas the NTHi strains do not express a polysaccharide capsule. In this review, we highlight the current advances in the field of H. influenzae , with the focus on bacterial virulence mechanisms that facilitate bacterial colonization and disease, particularly for NTHi. Recent findings In the past decade, it has become apparent that NTHi has the ability to cause invasive infections. Recently, a number of adhesins have been shown to be crucial for bacterial colonization and invasion and these proteins were investigated as vaccine antigens. Although NTHi lacks a polysaccharide capsule, it expresses lipooligosaccharide that contribute to adhesion and evasion of complement-mediated killing, both contributing to bacterial virulence, which could potentially be targeted by novel antimicrobial drugs or vaccines. Summary The unraveling of H. influenzae virulence mechanisms resulted in the identification of promising targets for novel antimicrobials and vaccine antigens aiming to prevent or treat both typeable and nontypeable H. influenzae infections." @default.
- W3017043534 created "2020-04-24" @default.
- W3017043534 creator A5064627325 @default.
- W3017043534 creator A5068063896 @default.
- W3017043534 date "2020-06-01" @default.
- W3017043534 modified "2023-09-27" @default.
- W3017043534 title "Unraveling Haemophilus influenzae virulence mechanisms enable discovery of new targets for antimicrobials and vaccines" @default.
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- W3017043534 doi "https://doi.org/10.1097/qco.0000000000000645" @default.
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