Matches in SemOpenAlex for { <https://semopenalex.org/work/W3017053229> ?p ?o ?g. }
- W3017053229 endingPage "128226" @default.
- W3017053229 startingPage "128226" @default.
- W3017053229 abstract "Abstract In this work, a new salt of clofazimine (CFZ) with 4-aminobenzoic acid (PABA is described. CFZ is an antibiotic drug used in the treatment of leprosy. This drug has low absorption when administered orally because of its low water solubility, contributing to the reduction of bioavailability, limiting its application. Towards the augmentation of the bioavailability of CFZ, we propose in this work the development of a salt. The new product CFZ+–PABA– (1:1) was synthesized through liquid assisted grinding method and characterized by powder X-ray diffraction, mid-infrared spectroscopy, and differential scanning calorimetry. The investigations provided evidence of the formation of a new salt. The interaction involves proton transfer between PABA and CFZ forming R 2 1 ( 7 ) motif in carboxylate region (COO−) of PABA and imines regions (N–H/N+–H) of CFZ. According to the analyses, the stoichiometric ratio of salt formation is 1:1. The salt dissolution profile shows the product is 5.0 folds more soluble than the CFZ free base." @default.
- W3017053229 created "2020-04-24" @default.
- W3017053229 creator A5041192920 @default.
- W3017053229 creator A5044224552 @default.
- W3017053229 creator A5050128393 @default.
- W3017053229 creator A5050309073 @default.
- W3017053229 creator A5080877383 @default.
- W3017053229 creator A5081034607 @default.
- W3017053229 date "2020-08-01" @default.
- W3017053229 modified "2023-09-24" @default.
- W3017053229 title "A new salt of clofazimine to improve leprosy treatment" @default.
- W3017053229 cites W1970288803 @default.
- W3017053229 cites W1971181330 @default.
- W3017053229 cites W1973488401 @default.
- W3017053229 cites W1996334926 @default.
- W3017053229 cites W1998787826 @default.
- W3017053229 cites W2006320900 @default.
- W3017053229 cites W2024071582 @default.
- W3017053229 cites W2025653403 @default.
- W3017053229 cites W2035034315 @default.
- W3017053229 cites W2040518011 @default.
- W3017053229 cites W2043396461 @default.
- W3017053229 cites W2052995349 @default.
- W3017053229 cites W2064288191 @default.
- W3017053229 cites W2064981002 @default.
- W3017053229 cites W2067129640 @default.
- W3017053229 cites W2068754430 @default.
- W3017053229 cites W2075111625 @default.
- W3017053229 cites W2083173953 @default.
- W3017053229 cites W2083487084 @default.
- W3017053229 cites W2086045386 @default.
- W3017053229 cites W2090769267 @default.
- W3017053229 cites W2091287597 @default.
- W3017053229 cites W2121444977 @default.
- W3017053229 cites W2132216432 @default.
- W3017053229 cites W2143408925 @default.
- W3017053229 cites W2150488496 @default.
- W3017053229 cites W2151114776 @default.
- W3017053229 cites W2152352703 @default.
- W3017053229 cites W2168954517 @default.
- W3017053229 cites W2281057791 @default.
- W3017053229 cites W2306008664 @default.
- W3017053229 cites W2314506216 @default.
- W3017053229 cites W2319019754 @default.
- W3017053229 cites W2319163086 @default.
- W3017053229 cites W2319327488 @default.
- W3017053229 cites W2322639880 @default.
- W3017053229 cites W2330655685 @default.
- W3017053229 cites W2332484484 @default.
- W3017053229 cites W2466853913 @default.
- W3017053229 cites W2509924851 @default.
- W3017053229 cites W2516818299 @default.
- W3017053229 cites W2523300513 @default.
- W3017053229 cites W2565991410 @default.
- W3017053229 cites W2578058688 @default.
- W3017053229 cites W2603444515 @default.
- W3017053229 cites W2603899979 @default.
- W3017053229 cites W2773638645 @default.
- W3017053229 cites W2778308909 @default.
- W3017053229 cites W2952528349 @default.
- W3017053229 cites W4233062044 @default.
- W3017053229 doi "https://doi.org/10.1016/j.molstruc.2020.128226" @default.
- W3017053229 hasPublicationYear "2020" @default.
- W3017053229 type Work @default.
- W3017053229 sameAs 3017053229 @default.
- W3017053229 citedByCount "8" @default.
- W3017053229 countsByYear W30170532292020 @default.
- W3017053229 countsByYear W30170532292021 @default.
- W3017053229 countsByYear W30170532292022 @default.
- W3017053229 countsByYear W30170532292023 @default.
- W3017053229 crossrefType "journal-article" @default.
- W3017053229 hasAuthorship W3017053229A5041192920 @default.
- W3017053229 hasAuthorship W3017053229A5044224552 @default.
- W3017053229 hasAuthorship W3017053229A5050128393 @default.
- W3017053229 hasAuthorship W3017053229A5050309073 @default.
- W3017053229 hasAuthorship W3017053229A5080877383 @default.
- W3017053229 hasAuthorship W3017053229A5081034607 @default.
- W3017053229 hasConcept C16005928 @default.
- W3017053229 hasConcept C178790620 @default.
- W3017053229 hasConcept C185592680 @default.
- W3017053229 hasConcept C2776297342 @default.
- W3017053229 hasConcept C2776371256 @default.
- W3017053229 hasConcept C2780695269 @default.
- W3017053229 hasConcept C71924100 @default.
- W3017053229 hasConceptScore W3017053229C16005928 @default.
- W3017053229 hasConceptScore W3017053229C178790620 @default.
- W3017053229 hasConceptScore W3017053229C185592680 @default.
- W3017053229 hasConceptScore W3017053229C2776297342 @default.
- W3017053229 hasConceptScore W3017053229C2776371256 @default.
- W3017053229 hasConceptScore W3017053229C2780695269 @default.
- W3017053229 hasConceptScore W3017053229C71924100 @default.
- W3017053229 hasFunder F4320321091 @default.
- W3017053229 hasFunder F4320323642 @default.
- W3017053229 hasFunder F4320334779 @default.
- W3017053229 hasLocation W30170532291 @default.
- W3017053229 hasOpenAccess W3017053229 @default.
- W3017053229 hasPrimaryLocation W30170532291 @default.
- W3017053229 hasRelatedWork W1989883637 @default.