Matches in SemOpenAlex for { <https://semopenalex.org/work/W3017086979> ?p ?o ?g. }
- W3017086979 endingPage "1892" @default.
- W3017086979 startingPage "1884" @default.
- W3017086979 abstract "Background/Objective Coagulation factor V (FV), a multidomain glycoprotein, is an essential cofactor in the blood clotting cascade. FV deficiency is a rare bleeding disorder that results in poor clotting after an injury or surgery. The only treatment for the disease is infusions of fresh frozen plasma and blood platelets. Glycosylation affects the biological activity, pharmacokinetics, immunogenicity, and in vivo clearance rate of proteins in the plasma. The glycan profile of FV, as well as how it affects the activity, stability, and immunogenicity, remains unknown. Methods In this study, we comprehensively mapped the glycosylation patterns of human plasma-derived FV by combining multienzyme digestion, hydrophilic interaction chromatography enrichment of glycopeptides, and alternated fragmentation mass spectrometry analysis. Results/Conclusion A total of 57 unique N-glycopeptides and 51 O-glycopeptides were identified, which were categorized into 40 N-glycan and 17 O-glycan compositions. Such glycosylation details are fundamental for future functional studies and therapeutics development. In addition, the established methodology can be readily applied to analyze glycosylation patterns of proteins with more than 2000 amino acids." @default.
- W3017086979 created "2020-04-24" @default.
- W3017086979 creator A5003517185 @default.
- W3017086979 creator A5004243420 @default.
- W3017086979 creator A5004680481 @default.
- W3017086979 creator A5010173370 @default.
- W3017086979 creator A5014530935 @default.
- W3017086979 creator A5022447244 @default.
- W3017086979 creator A5050081399 @default.
- W3017086979 creator A5060240351 @default.
- W3017086979 creator A5069579263 @default.
- W3017086979 creator A5069631685 @default.
- W3017086979 creator A5075889094 @default.
- W3017086979 creator A5085701223 @default.
- W3017086979 date "2020-08-01" @default.
- W3017086979 modified "2023-09-28" @default.
- W3017086979 title "Comprehensive N‐ and O‐glycosylation mapping of human coagulation factor V" @default.
- W3017086979 cites W13069020 @default.
- W3017086979 cites W1502636908 @default.
- W3017086979 cites W1526076455 @default.
- W3017086979 cites W1539413326 @default.
- W3017086979 cites W1545489129 @default.
- W3017086979 cites W1569602075 @default.
- W3017086979 cites W1601861562 @default.
- W3017086979 cites W1604651284 @default.
- W3017086979 cites W1896702999 @default.
- W3017086979 cites W1979080634 @default.
- W3017086979 cites W1983967302 @default.
- W3017086979 cites W1998788509 @default.
- W3017086979 cites W1999875102 @default.
- W3017086979 cites W2001264094 @default.
- W3017086979 cites W2002523859 @default.
- W3017086979 cites W2015041168 @default.
- W3017086979 cites W2017595512 @default.
- W3017086979 cites W2018958401 @default.
- W3017086979 cites W2019908848 @default.
- W3017086979 cites W2021283345 @default.
- W3017086979 cites W2036778801 @default.
- W3017086979 cites W2037199116 @default.
- W3017086979 cites W2040427797 @default.
- W3017086979 cites W2040470885 @default.
- W3017086979 cites W2061967868 @default.
- W3017086979 cites W2079050804 @default.
- W3017086979 cites W2087850432 @default.
- W3017086979 cites W2095299242 @default.
- W3017086979 cites W2110068024 @default.
- W3017086979 cites W2123142240 @default.
- W3017086979 cites W2137354517 @default.
- W3017086979 cites W2167633411 @default.
- W3017086979 cites W2319705746 @default.
- W3017086979 cites W2509144358 @default.
- W3017086979 cites W2528779404 @default.
- W3017086979 cites W2591498323 @default.
- W3017086979 cites W2735073700 @default.
- W3017086979 cites W2790177148 @default.
- W3017086979 cites W2808009529 @default.
- W3017086979 cites W2838250877 @default.
- W3017086979 cites W2845051690 @default.
- W3017086979 cites W4234678458 @default.
- W3017086979 doi "https://doi.org/10.1111/jth.14861" @default.
- W3017086979 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7732234" @default.
- W3017086979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32310329" @default.
- W3017086979 hasPublicationYear "2020" @default.
- W3017086979 type Work @default.
- W3017086979 sameAs 3017086979 @default.
- W3017086979 citedByCount "7" @default.
- W3017086979 countsByYear W30170869792020 @default.
- W3017086979 countsByYear W30170869792021 @default.
- W3017086979 countsByYear W30170869792023 @default.
- W3017086979 crossrefType "journal-article" @default.
- W3017086979 hasAuthorship W3017086979A5003517185 @default.
- W3017086979 hasAuthorship W3017086979A5004243420 @default.
- W3017086979 hasAuthorship W3017086979A5004680481 @default.
- W3017086979 hasAuthorship W3017086979A5010173370 @default.
- W3017086979 hasAuthorship W3017086979A5014530935 @default.
- W3017086979 hasAuthorship W3017086979A5022447244 @default.
- W3017086979 hasAuthorship W3017086979A5050081399 @default.
- W3017086979 hasAuthorship W3017086979A5060240351 @default.
- W3017086979 hasAuthorship W3017086979A5069579263 @default.
- W3017086979 hasAuthorship W3017086979A5069631685 @default.
- W3017086979 hasAuthorship W3017086979A5075889094 @default.
- W3017086979 hasAuthorship W3017086979A5085701223 @default.
- W3017086979 hasBestOaLocation W30170869791 @default.
- W3017086979 hasConcept C108625454 @default.
- W3017086979 hasConcept C118552586 @default.
- W3017086979 hasConcept C137610392 @default.
- W3017086979 hasConcept C159654299 @default.
- W3017086979 hasConcept C185592680 @default.
- W3017086979 hasConcept C203014093 @default.
- W3017086979 hasConcept C206212055 @default.
- W3017086979 hasConcept C2777313579 @default.
- W3017086979 hasConcept C2778382381 @default.
- W3017086979 hasConcept C2780868878 @default.
- W3017086979 hasConcept C501593827 @default.
- W3017086979 hasConcept C55493867 @default.
- W3017086979 hasConcept C71924100 @default.
- W3017086979 hasConcept C86803240 @default.
- W3017086979 hasConceptScore W3017086979C108625454 @default.